Results 101 to 110 of about 212,786 (294)
Journal of Translational Medicine, 2020 Background Papillary thyroid carcinoma (PTC), which is the most common endocrine malignancy, has been steadily increasing worldwide in incidence over the years, while mechanisms underlying the pathogenesis and diagnostic for PTC are incomplete.
Yang Liu +5 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Identification of the potential biomarkers in patients with glioma: a weighted gene co-expression network analysis [PDF]
Carcinogenesis, 2019 Abstract Glioma is the most common brain tumor with high mortality. However, there are still challenges for the timely and accurate diagnosis and effective treatment of the tumor. One hundred and twenty-one samples with grades II, III and IV from the Gene Expression Omnibus database were used to construct gene co-expression networks to ...
Chen, Ting-Yu +5 more
openaire +2 more sources
Cellular Oncology, 2017 Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal prognosis which is, among others, due to a lack of suitable biomarkers and therapeutic targets.
M. Giulietti +3 more
semanticscholar +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
MODA: MOdule Differential Analysis for weighted gene co-expression network [PDF]
, 2016 1 Summary Gene co-expression network differential analysis is designed to help biologists understand gene expression patterns under different conditions. We have implemented an R package called MODA (Module Differential Analysis) for gene co-expression network differential analysis. Based on transcriptomic data, MODA can
Li, Dong +5 more
openaire +2 more sources
Scientific ReportsIntrahepatic cholangiocarcinoma (ICCA) is a highly aggressive bile duct cancer with limited treatment options and poor prognosis. This study aims to develop a gene signature-based model to predict ICCA patient survival.
Dongyao Xu +5 more
doaj +1 more source
BMC Cardiovascular Disorders, 2016 BackgroundThe analysis of the potential molecule targets of coronary artery disease (CAD) is critical for understanding the molecular mechanisms of disease.
Jing Liu, Ling Jing, Xilin Tu
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
BMC Medical Genomics, 2023 The risk of severe condition caused by Corona Virus Disease 2019 (COVID-19) increases with age. However, the underlying mechanisms have not been clearly understood. The dataset GSE157103 was used to perform weighted gene co-expression network analysis on
Yao Lin +13 more
doaj +1 more source