Results 81 to 90 of about 212,786 (294)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Novel prognostic genes and subclasses of acute myeloid leukemia revealed by survival analysis of gene expression data

BMC Medical Genomics, 2021
Background Acute myeloid leukemia (AML) is biologically heterogeneous diseases with adverse prognosis. This study was conducted to find prognostic biomarkers that could effectively classify AML patients and provide guidance for treatment decision making.
Yanli Lai, Guifang OuYang, Lixia Sheng, Yanli Zhang, Binbin Lai, Miao Zhou   +5 more
doaj   +1 more source

Weighted gene co-expression network analysis reveals the hub genes and molecular mechanism of quiescence. [PDF]

3 Biotech
The hematopoietic stem cell (HSC) continues their functional integrity and return to quiescence quickly even after inflammatory and other proliferative stress. The mechanism which is responsible for this highly regulatory process is not understood clearly.
Apoorvha JP, Brindha S, Ganesan M, Roy S.   +3 more
europepmc   +4 more sources

The Identification and Validation of Hub Genes Associated with Acute Myocardial Infarction Using Weighted Gene Co-Expression Network Analysis

Journal of Cardiovascular Development and Disease, 2022
Acute myocardial infarction (AMI), one of the most severe and fatal cardiovascular diseases, remains the main cause of mortality and morbidity worldwide.
Junqiang Xue, Lu Chen, Hao Cheng, Xiao-Yue Song, Yuekai Shi, Lin-Nan Li, Ren-De Xu, Q. Qin, Jianying Ma, Jun-Bo Ge   +9 more
semanticscholar   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Identification of Prognostic Genes in Leiomyosarcoma by Gene Co-Expression Network Analysis

Frontiers in Genetics, 2020
Background/AimsLeiomyosarcoma (LMS) is a tumor derived from malignant mesenchymal tissue associated with poor prognosis. Determining potential prognostic markers for LMS can provide clues for early diagnosis, recurrence, and treatment.Methods RNA ...
Jun Yang, Cuili Li, Jiaying Zhou, Xiaoquan Liu, Shaohua Wang   +4 more
doaj   +1 more source

Gene Correlation Network Analysis to Identify Biomarkers of Peri-Implantitis

Medicina, 2022
Background and Objectives: The histopathological and clinical conditions for transforming peri-implant mucositis into peri-implantitis (PI) are not fully clarified. We aim to uncover molecular mechanisms and new potential biomarkers of PI.
Binghuan Sun, Wei Zhang, Xin Song, Xin Wu   +3 more
doaj   +1 more source

Weighted Gene Co-expression Network Analysis of Endometriosis and Identification of Functional Modules Associated With Its Main Hallmarks

Frontiers in Genetics, 2018
Although many genes have been identified using high throughput technologies in endometriosis (ES), only a small number of individual genes have been analyzed functionally.
M. Bakhtiarizadeh, B. Hosseinpour, Maryam Shahhoseini, A. Korte, P. Gifani   +4 more
semanticscholar   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Investigation of hub gene associated with the infection of Staphylococcus aureus via weighted gene co-expression network analysis

BMC Microbiology, 2021
Introduction Staphylococcus aureus is a gram-positive bacterium that causes serious infection. With the increasing resistance of bacteria to current antibiotics, it is necessary to learn more about the molecular mechanism and cellular pathways involved ...
Jia-xin Li, Xun-jie Cao, Yuan-yi Huang, Ya-ping Li, Zi-yuan Yu, Min Lin, Qiu-ying Li, Ji-chun Chen, Xu-guang Guo   +8 more
doaj   +1 more source