Results 71 to 80 of about 212,786 (294)

Identification of Crucial Genes Associated With Immune Cell Infiltration in Hepatocellular Carcinoma by Weighted Gene Co-expression Network Analysis

Frontiers in Genetics, 2020
The dreadful prognosis of hepatocellular carcinoma (HCC) is primarily due to the low early diagnosis rate, rapid progression, and high recurrence rate. Valuable prognostic biomarkers are urgently needed for HCC.
Dengchuan Wang, Jun Liu, Shengshuo Liu, Wenli Li   +3 more
semanticscholar   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Identification of hub genes in liver hepatocellular carcinoma based on weighted gene co-expression network analysis

Biochemical Genetics, 2023
Abstract Methods: Our study mainly used The Cancer Genome Atlas (TCGA) LIHC database and the gene expression profiles of GSE54236 from the Gene Expression Omnibus (GEO) to explore the differential co-expression genes between LIHC and normal tissues.
Sun, Jiawei, Zhang, Zizhen, Cai, Jiaru, Li, Xiaoping, Xu, Xiaoling   +4 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Machine learning and weighted gene co-expression network analysis identify a three-gene signature to diagnose rheumatoid arthritis

Frontiers in Immunology
Background Rheumatoid arthritis (RA) is a systemic immune-related disease characterized by synovial inflammation and destruction of joint cartilage. The pathogenesis of RA remains unclear, and diagnostic markers with high sensitivity and specificity are ...
Ying-Kai Wu, Caixia Liu, Chao Liu, Jun Wu, Zongxiu Xie   +4 more
semanticscholar   +1 more source

Identifying Key Genes and Functionally Enriched Pathways in Sjögren’s Syndrome by Weighted Gene Co-Expression Network Analysis

Frontiers in Genetics, 2019
Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by dry mouth and eyes. To date, the exact molecular mechanisms of its etiology are still largely unknown.
Qiuming Yao, Zhen-yu Song, Bin Wang, Q. Qin, Jin-An Zhang   +4 more
semanticscholar   +1 more source

Weighted gene co‑expression network analysis in identification of key genes and networks for ischemic‑reperfusion remodeling myocardium

Molecular Medicine Reports, 2018
Acute myocardial infarction induces ventricular remodeling, which is implicated in dilated heart and heart failure. The pathogenical mechanism of myocardium remodeling remains to be elucidated. The aim of the present study was to identify key genes and networks for myocardium remodeling following ischemia‑reperfusion (IR).
Guo, Nan, Zhang, Nan, Yan, Liqiu, Lian, Zheng, Wang, Jiawang, Lv, Fengfeng, Wang, Yunfei, Cao, Xufen   +7 more
openaire   +3 more sources

Identification of prognostic biomarkers for papillary thyroid carcinoma by a weighted gene co‐expression network analysis

Cancer Medicine, 2022
Aim Whole transcriptome analysis was conducted to identify differentially expressed RNAs and regulatory networks associated with papillary thyroid carcinoma (PTC). Methods A weighted gene co‐expression network analysis based on high‐throughput sequencing
Kexin Meng, Xiaotian Hu, Guowan Zheng, Chenhong Qian, Ying Xin, Haiwei Guo, Ru He, Minghua Ge, Jiajie Xu   +8 more
doaj   +1 more source

Identification of hub genes in colorectal cancer based on weighted gene co-expression network analysis and clinical data from The Cancer Genome Atlas

Bioscience Reports, 2021
Colorectal cancer (CRC) is one of the most common tumors worldwide and is associated with high mortality. Here we performed bioinformatics analysis, which we validated using immunohistochemistry in order to search for hub genes that might serve as ...
Yu Zhang, Jia Luo, Zhe Liu, Xudong Liu, Ying-Ying Ma, Bohang Zhang, Yuxuan Chen, Xiao-Feng Li, Zhiwei Feng, Ning Yang, D. Feng, Lei Wang, Xin-Qiang Song   +12 more
semanticscholar   +1 more source