Results 71 to 80 of about 148,880 (283)

Immune infiltration landscape and immune-marker molecular typing of pulmonary fibrosis with pulmonary hypertension

BMC Pulmonary Medicine, 2021
Background Pulmonary arterial hypertension (PH) secondary to pulmonary fibrosis (PF) is one of the most common complications in PF patients, it causes severe disease and usually have a poor prognosis.
Haomin Cai, Hongcheng Liu
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Identification of Prognostic Genes in Leiomyosarcoma by Gene Co-Expression Network Analysis

Frontiers in Genetics, 2020
Background/AimsLeiomyosarcoma (LMS) is a tumor derived from malignant mesenchymal tissue associated with poor prognosis. Determining potential prognostic markers for LMS can provide clues for early diagnosis, recurrence, and treatment.Methods RNA ...
Jun Yang, Cuili Li, Jiaying Zhou, Xiaoquan Liu, Shaohua Wang   +4 more
doaj   +1 more source

Weighted gene co-expression network analysis revealed T cell differentiation associated with the age-related phenotypes in COVID-19 patients

BMC Medical Genomics, 2023
The risk of severe condition caused by Corona Virus Disease 2019 (COVID-19) increases with age. However, the underlying mechanisms have not been clearly understood. The dataset GSE157103 was used to perform weighted gene co-expression network analysis on
Yao Lin, Yueqi Li, Hubin Chen, Jun Meng, Jingyi Li, Jiemei Chu, Ruili Zheng, Hailong Wang, Peijiang Pan, Jinming Su, Junjun Jiang, Li Ye, Hao Liang, Sanqi An   +13 more
doaj   +1 more source

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes. [PDF]

, 2018
Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes.
A Battle, A Krishnan, A Perry, A Schroeder, A Sugathan, A Venter, AJ Willsey, AM Wetherby, AR McIntosh, AR Pfenning, AT Hilliard, BS Abrahams, C Demopoulos, C Lord, CR Genovese, Cynthia Carter Barnes, DA Rossignol, DH Geschwind, DH Geschwind, DL Vargas, E Redcay, E Redcay, EA Boyle, EJ Greenblatt, Eric Courchesne, F Happé, G Dehaene-Lambertz, G Hickok, G Konopka, G Konopka, H Tager-Flusberg, HR Cremers, I Voineagu, J Cotney, JA Kosmicki, JA Miller, JC Darnell, JD Storey, JI Berman, JT Morgan, K Gotham, K Pierce, K Pierce, K Pierce, Karen Pierce, L Hippolyte, Linda Lopez, Lisa Eyler, LT Eyler, M Chikina, M Lek, MC Lai, MC Oldham, MCN Marchetto, ME Ritchie, Michael V. Lombardo, MM Kjelgaard, MV Lombardo, Nathan E. Lewis, NN Parikshak, NN Parikshak, NR Wray, P Du, P Howlin, P Langfelder, P Langfelder, P Szatmari, R Bernier, RC Gentleman, Richard A. I. Bethlehem, RJ Kelleher III, S Kapur, S Rubeis De, S Sandin, SJ Sanders, T Pramparo, T Pramparo, T Yarkoni, Tiziano Pramparo, Vahid Gazestani, Varun Warrier, X Liu, X Nuttle   +82 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Identification of prognostic biomarkers for papillary thyroid carcinoma by a weighted gene co‐expression network analysis

Cancer Medicine, 2022
Aim Whole transcriptome analysis was conducted to identify differentially expressed RNAs and regulatory networks associated with papillary thyroid carcinoma (PTC). Methods A weighted gene co‐expression network analysis based on high‐throughput sequencing
Kexin Meng, Xiaotian Hu, Guowan Zheng, Chenhong Qian, Ying Xin, Haiwei Guo, Ru He, Minghua Ge, Jiajie Xu   +8 more
doaj   +1 more source

Transcriptome Analyses of Tumor-Adjacent Somatic Tissues Reveal Genes Co-Expressed with Transposable Elements [PDF]

, 2019
Background: Despite the long-held assumption that transposons are normally only expressed in the germ-line, recent evidence shows that transcripts of transposable element (TE) sequences are frequently found in the somatic cells.
Alberto, Adrian, Chung, Micky, Churchill, Daphnie, Clymer, Cody, Han, Mira V., Jonaid, G. M., Navarro Leija, Omar, Quinton, Sophia, Ross, Austin, Sexton, Corinne E.   +9 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Gene Correlation Network Analysis to Identify Biomarkers of Peri-Implantitis

Medicina, 2022
Background and Objectives: The histopathological and clinical conditions for transforming peri-implant mucositis into peri-implantitis (PI) are not fully clarified. We aim to uncover molecular mechanisms and new potential biomarkers of PI.
Binghuan Sun, Wei Zhang, Xin Song, Xin Wu   +3 more
doaj   +1 more source