Results 91 to 100 of about 45,444 (316)

Identification of important modules and biomarkers in tuberculosis based on WGCNA

Frontiers in Microbiology
BackgroundTuberculosis (TB) is a significant public health concern, particularly in China. Long noncoding RNAs (lncRNAs) can provide abundant pathological information regarding etiology and could include candidate biomarkers for diagnosis of TB. However, data regarding lncRNA expression profiles and specific lncRNAs associated with TB are limited ...
Jing Dong, Jing Dong, Jing Dong, Ruixue Song, Ruixue Song, Ruixue Song, Xuetian Shang, Xuetian Shang, Xuetian Shang, Yingchao Wang, Yingchao Wang, Yingchao Wang, Qiuyue Liu, Qiuyue Liu, Zhiguo Zhang, Hongyan Jia, Hongyan Jia, Hongyan Jia, Mailing Huang, Mailing Huang, Chuanzhi Zhu, Chuanzhi Zhu, Chuanzhi Zhu, Qi Sun, Qi Sun, Qi Sun, Boping Du, Boping Du, Boping Du, Aiying Xing, Aiying Xing, Aiying Xing, Zihui Li, Zihui Li, Zihui Li, Lanyue Zhang, Lanyue Zhang, Lanyue Zhang, Liping Pan, Liping Pan, Liping Pan, Zongde Zhang, Zongde Zhang, Zongde Zhang   +43 more
openaire   +3 more sources

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

WGCNA-ML-MR integration: uncovering immune-related genes in prostate cancer

Frontiers in Oncology
BackgroundProstate cancer is one of the most common tumors in men, with its incidence and mortality rates continuing to rise year by year. Prostate-specific antigen (PSA) is the most commonly used screening indicator, but its lack of specificity leads to overdiagnosis and overtreatment.
Jing Lv, Jing Lv, Yuhua Zhou, Yuhua Zhou, Shengkai Jin, Shengkai Jin, Chaowei Fu, Chaowei Fu, Yang Shen, Yang Shen, Bo Liu, Bo Liu, Menglu Li, Yuwei Zhang, Yuwei Zhang, Ninghan Feng, Ninghan Feng, Ninghan Feng   +17 more
openaire   +3 more sources

Identification of ferroptosis‐related genes involved in chronic obstructive pulmonary disease based on bioinformatics analysis

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Green part represents the bioinformatics analysis approach. Yellow part represents the ideas of animal experiment. Abstract Background Chronic obstructive pulmonary disease (COPD) is a type of chronic respiratory disease.
Xuejing Luan, Jinghui Xie, Lu Zhang, Xiao Ma, Lichangtian Jiao, Jie Zhu   +5 more
wiley   +1 more source

Super-Enhancer-Associated Hub Genes In Chronic Myeloid Leukemia Identified Using Weighted Gene Co-Expression Network Analysis

Cancer Management and Research, 2019
Hongying Ma,1,2 Jian Qu,3 Jian Luo,1,2 Tingting Qi,3 Huanmiao Tan,4 Zhaohui Jiang,1 Haiwen Zhang,1 Qiang Qu1,2 1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People’s Republic of China; 2Institute for ...
Ma H, Qu J, Luo J, Qi T, Tan H, Jiang Z, Zhang H, Qu Q   +7 more
doaj  

Hub genes and diagnostic model associated with mitochondrial function in Alzheimer's disease

Animal Models and Experimental Medicine, EarlyView.
Alzheimer's disease (AD) is the most common neurodegenerative disorder, and mitochondrial dysfunction has been confirmed in AD patients and mouse models. However, the pathogenic genes associated with AD and early diagnostic methods based on mitochondrial function remain to be explored.
Xuchao Zhu, Ling Zhang, Chuan Qin
wiley   +1 more source

Multi-Transcriptomic Analysis and Experimental Validation Implicate a Central Role of STAT3 in Skin Barrier Dysfunction Induced Aggravation of Rosacea

Journal of Inflammation Research, 2022
Yaling Wang,1,2 Ben Wang,1,2 Yingxue Huang,1 Yangfan Li,1,2 Sha Yan,1 Hongfu Xie,1– 3 Yiya Zhang,1– 3 Ji Li1– 3 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Hunan Key Laboratory of Aging ...
Wang Y, Wang B, Huang Y, Li Y, Yan S, Xie H, Zhang Y, Li J   +7 more
doaj  

Stability Indicators in Network Reconstruction [PDF]

, 2012
The number of algorithms available to reconstruct a biological network from a dataset of high-throughput measurements is nowadays overwhelming, but evaluating their performance when the gold standard is unknown is a difficult task. Here we propose to use
Filosi, Michele, Furlanello, Cesare, Jurman, Giuseppe, Riccadonna, Samantha, Visintainer, Roberto   +4 more
core  

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

Annals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang, Taylor L. Charron, Min Fu, Miranda Dunn, Deborah M. Jones, Praveen Kumar, Satoshi Ishishita, Allan‐Hermann Pool, Ashwinikumar Kulkarni, Genevieve Konopka, Vikram G. Shakkottai   +10 more
wiley   +1 more source

Identification of a Five-Gene Prognostic Signature Related to B Cells Infiltration in Pancreatic Adenocarcinoma

International Journal of General Medicine, 2021
Shaomei Tang,1 Xiaoliang Huang,2 Haixing Jiang,1 Shanyu Qin1 1Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China; 2Department of Gastrointestinal Surgery, Guangxi Medical ...
Tang S, Huang X, Jiang H, Qin S
doaj