Results 91 to 100 of about 53,418 (326)
Advanced Science, EarlyView.This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu +17 more
wiley +1 more source
Epigenetics, 2022 Prenatal exposure to endocrine disrupting chemicals can interfere with development, and has been associated with social-cognitive functioning and adverse health outcomes later in life.
Katharina Mattonet +11 more
doaj +1 more source
Frontiers in NeuroscienceBackground Alzheimer’s disease (AD) is a common, refractory, progressive neurodegenerative disorder in which cognitive and memory deficits are highly correlated with abnormalities in hippocampal brain regions. There is still a lack of hippocampus-related
Yang Chen +4 more
semanticscholar +1 more source
ManiNetCluster: a novel manifold learning approach to reveal the functional links between gene networks. [PDF]
, 2019 BACKGROUND:The coordination of genomic functions is a critical and complex process across biological systems such as phenotypes or states (e.g., time, disease, organism, environmental perturbation).
Blaby, Ian K +2 more
core
Modeling the functional genomics of autism using human neurons. [PDF]
, 2012 Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation,
Chen, L +10 more
core +1 more source
Advanced Science, EarlyView.Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong +19 more
wiley +1 more source
Cancer Management and Research, 2021 Fang Cao,1,* Yinchun Fan,1,* Yunhu Yu,2 Guohua Yang,3 Hua Zhong4 1Department of Cerebrovascular Disease, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 2Clinical Research Center for ...
Cao F, Fan Y, Yu Y, Yang G, Zhong H
doaj
K-Module Algorithm: An Additional Step to Improve the Clustering Results of WGCNA Co-Expression Networks [PDF]
, 2021 Jie Hou +3 more
openalex +1 more source
Advanced Science, EarlyView.This study reveals that specific genetic variations in gut‐residing Saccharomyces cerevisiae significantly extend healthspan and lifespan in Drosophila melanogaster. These mutants rejuvenate aged intestinal metabolism, upregulate mitochondrial proteins, and enhance energy pathways.
Liying Wang +11 more
wiley +1 more source
Mineral element contents and gene expression in Sophora tonkinensis during florescence
Biotechnology & Biotechnological Equipment, 2021 As a medicinal plant, Sophora tonkinensis is mainly distributed in Guangxi, Yunnan, Guizhou and northern Vietnam. In recent years, due to the strong demand for S. tonkinensis, wild resources have become decreased, which has placed great pressure on their
Lin-xuan Li +9 more
doaj +1 more source