Results 81 to 90 of about 47,201 (334)

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

Analysis of Gene Co-Expression Network to Identify the Role of CD8 + T Cell Infiltration-Related Biomarkers in High-Grade Glioma

International Journal of General Medicine, 2022
Peng Feng,1,* Yuchen Li,2,* Zhijie Tian,1,* Yuan Qian,1 Xingyu Miao,1 Yuelin Zhang3 1Neurosurgery, Shaanxi Provincial People’s Hospital, Xian, 710068, People’s Republic of China; 2Hengyang Medical School, University of South China, Hengyang ...
Feng P, Li Y, Tian Z, Qian Y, Miao X, Zhang Y   +5 more
doaj  

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. [PDF]

, 2016
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths.
A Dobin, A Hodges, A Kuhn, A Pal, A Reiner, A Valencia, Andreas Tebbe, B Zhang, B Zhang, BM Bolstad, C Zuccato, CA Ross, Christoph Schaab, Daniel J Lavery, David Howland, DI Shirasaki, Doxa Chatzopoulou, DV Zaykin, EH Aylward, Eliana Marisa Ramos, ES Deneris, ES Lein, Fuying Gao, G Fishell, GA Smith, Giovanni Coppola, HT Orr, I Al-Ramahi, IS Seong, Ismael Al-Ramahi, J Cox, J Cox, J Labbadia, JA Miller, JC Jacobsen, JE Phillips, Jeffrey P Cantle, Jeffrey S Aaronson, JF Gusella, JF Gusella, Jim Rosinski, JM Dowen, JM Van Raamsdonk, JP Vonsattel, Juan Botas, K Becanovic, K Monahan, K Sharma, Karla El-Zein, LB Menalled, LB Menalled, LB Menalled, LS Kaltenbach, M Biagioli, M Heiman, M MACDONALD, M Mann, M Mielcarek, MA Pouladi, MC Oldham, MI Love, MK Lobo, MT Lin, N Wang, Nan Wang, P Giles, P Grange, P Langfelder, P Langfelder, P Langfelder, P Langfelder, P Langfelder, Peter Langfelder, PF Durrenberger, RC Gentleman, S Anders, S Horvath, S Toyoda, Sandeep Deverasetty, Seung Kwak, Steve Horvath, T Geiger, T Lu, WE Johnson, WV Chen, X Gu, X Gu, X William Yang, XH Lu, Xiao-Hong Lu, Y Benjamini, Y Guo, Y Shen, Y Wang, Yining Zhao   +94 more
core   +1 more source

Liver Kinase B1 in CD11c+ Cells Inhibits Fibrosis in Chronic Pancreatitis via the Oncostatin M Signaling

Advanced Science, EarlyView.
This study demonstrates significantly reduced Lkb1 expression in CD11c+ cells in chronic pancreatitis (CP) patients and animal models. Lkb1 deletion enhances CD11c+CD206+ macrophage infiltration and reprograms pancreatic stellate cells (PSCs) via OSM signaling.
Wenqing Zhang, Shan Guo, Yu Zhang, He Ren, Ke Lei, Chenyang Zhao, Qian Yu, Hongqing Luo, Yujing Xiao, Xiaoming Feng, Xiaoyu Li   +10 more
wiley   +1 more source

Unveiling microbial succession dynamics on different plastic surfaces using WGCNA

PLOS ONE
Over recent decades, marine microorganisms have increasingly adapted to plastic debris, forming distinct plastic-attached microbial communities. Despite this, the colonization and succession processes on plastic surfaces in marine environments remain poorly understood. To address this knowledge gap, we conducted a microbiome succession experiment using
Keren Davidov, Sheli Itzahri, Liat Anabel Sinberger, Matan Oren   +3 more
openaire   +3 more sources

Profiling the accumulation of ten bioactive compounds in Rheum officinale across different growth years using integrated HPLC and transcriptomic approaches

Medicinal Plant Biology
Rheum officinale is a prominent traditional medicinal herb in the Chinese Pharmacopeia. Variations in the composition and accumulation of secondary metabolites in R. officinale have been observed to correlate with harvest periods. This study investigated
Yi-min Li, Xue-ru Wang, Ge Yang, Ting-ting Yan, Xiao-chen Hu, Liang Peng, Jing Gao, Feng Yan, Gang Zhang   +8 more
doaj   +1 more source

Extracellular vesicles produced in B cells deliver tumor suppressor miR-335 to breast cancer cells disrupting oncogenic programming in vitro and in vivo. [PDF]

, 2018
The successful implementation of miRNA (miR) therapies in humans will ultimately rely on the use of vehicles with improved cellular delivery capability. Here we tested a new system that leverages extracellular vesicles (EVs) laden with a tumor suppressor
Almanza, Gonzalo, Carter, Hannah, Jepsen, Kristen, Rodvold, Jeffrey J, Tsui, Brian, Zanetti, Maurizio   +5 more
core   +2 more sources

A Novel CsYABBY3‐CsAS1 Feedback Loop Coordinates Trichome Differentiation and Cannabinoid Biosynthesis in Cannabis sativa L.

Advanced Science, EarlyView.
A novel transcriptional module involving CsYABBY3 and CsAS1 is identified to regulate cannabinoid biosynthesis and trichome development. These factors mutually activate each other and form a protein complex via a conserved residue, acting synergistically to amplify metabolic flux through a coordinate feed‐forward mechanism.
Xuewen Zhu, Yaolei Mi, Xue Cao, Weiqiang Chen, Pucheng Fan, Jing Wang, Yiming Zhang, Wei Yang, Huihua Wan, Shanshan Chen, Xiangxiao Meng, Jun Li, Shuo Shen, Mingkun Huang, Xiaoyu Zhang, Ming Luo, Shilin Chen, Zhichao Xu, Wei Sun   +18 more
wiley   +1 more source

Weighted Correlation Network Analysis Reveals CDK2 as a Regulator of a Ubiquitous Environmental Toxin-Induced Cell-Cycle Arrest

Cells, 2020
Environmental food contaminants constitute a threat to human health. For instance, the globally spread mycotoxin Ochratoxin A (OTA) contributes to chronic kidney damage by affecting proximal tubule cells via unknown mechanisms.
Virginie Dubourg, Alexander Nolze, Michael Kopf, Michael Gekle, Gerald Schwerdt   +4 more
doaj   +1 more source

Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin. [PDF]

, 2017
Human skin consists of multiple cell types, including epithelial, immune, and stromal cells. Transcriptomic analyses have previously been performed from bulk skin samples or from epithelial and immune cells expanded in cell culture.
Ahn, Richard S, Arron, Sarah T, Chang, David S, Gupta, Rashmi, Lai, Kevin, Lee, Kristina M, Liao, Wilson, Nititham, Joanne, Rosenblum, Michael, Taravati, Keyon   +9 more
core   +1 more source