Results 61 to 70 of about 47,201 (334)

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

WGCNA-based identification of potential targets and pathways in response to treatment in locally advanced breast cancer patients

Open Medicine, 2023
Locally advanced breast cancer patients have a poor prognosis; however, the relationship between potential targets and the response to treatment is still unclear.
Zhao Ruipeng, Wei Wan, Zhen Linlin
doaj   +1 more source

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes. [PDF]

, 2018
Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes.
A Battle, A Krishnan, A Perry, A Schroeder, A Sugathan, A Venter, AJ Willsey, AM Wetherby, AR McIntosh, AR Pfenning, AT Hilliard, BS Abrahams, C Demopoulos, C Lord, CR Genovese, Cynthia Carter Barnes, DA Rossignol, DH Geschwind, DH Geschwind, DL Vargas, E Redcay, E Redcay, EA Boyle, EJ Greenblatt, Eric Courchesne, F Happé, G Dehaene-Lambertz, G Hickok, G Konopka, G Konopka, H Tager-Flusberg, HR Cremers, I Voineagu, J Cotney, JA Kosmicki, JA Miller, JC Darnell, JD Storey, JI Berman, JT Morgan, K Gotham, K Pierce, K Pierce, K Pierce, Karen Pierce, L Hippolyte, Linda Lopez, Lisa Eyler, LT Eyler, M Chikina, M Lek, MC Lai, MC Oldham, MCN Marchetto, ME Ritchie, Michael V. Lombardo, MM Kjelgaard, MV Lombardo, Nathan E. Lewis, NN Parikshak, NN Parikshak, NR Wray, P Du, P Howlin, P Langfelder, P Langfelder, P Szatmari, R Bernier, RC Gentleman, Richard A. I. Bethlehem, RJ Kelleher III, S Kapur, S Rubeis De, S Sandin, SJ Sanders, T Pramparo, T Pramparo, T Yarkoni, Tiziano Pramparo, Vahid Gazestani, Varun Warrier, X Liu, X Nuttle   +82 more
core   +1 more source

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

Identification of Important Modules and Biomarkers in Breast Cancer Based on WGCNA.

OncoTargets and therapy, 2020
Breast cancer (BRCA) has the highest incidence among female malignancies, and the prognosis for these patients remains poor.In this study, core modules and central genes related to BRCA were identified through a weighted gene co-expression network analysis (WGCNA).
Tian,Zelin, He,Weixiang, Tang,Jianing, Liao,Xing, Yang,Qian, Wu,Yumin, Wu,Gaosong   +6 more
openaire   +3 more sources

Identification of Unique Transcriptomic Signatures and Hub Genes Through RNA Sequencing and Integrated WGCNA and PPI Network Analysis in Nonerosive Reflux Disease

Journal of Inflammation Research, 2021
Ye Zhao,1,* Teng Ma,2,* Duowu Zou1 1Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China; 2Department of Thoracic Surgery, Zhongshan Hospital, Fudan ...
Zhao Y, Ma T, Zou D
doaj  

Identification of potential key genes affecting soybean growth under salt stress via transcriptome study

Biologia Plantarum, 2020
Soybean is one of the most important economic crops in the world. However, the salinization of soil results in the decrease of soybean yield as it is only a moderately salt-tolerant crop.
N. LI, Z. LI, S. FAN, Y. PU, Y. GONG, R. TIAN, X. GUO, H. DING   +7 more
doaj   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

ManiNetCluster: a novel manifold learning approach to reveal the functional links between gene networks. [PDF]

, 2019
BACKGROUND:The coordination of genomic functions is a critical and complex process across biological systems such as phenotypes or states (e.g., time, disease, organism, environmental perturbation).
Blaby, Ian K, Nguyen, Nam D, Wang, Daifeng   +2 more
core  

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source