Results 61 to 70 of about 31,790 (245)

Analysis of Gene Co-Expression Network to Identify the Role of CD8 + T Cell Infiltration-Related Biomarkers in High-Grade Glioma

International Journal of General Medicine, 2022
Peng Feng,1,* Yuchen Li,2,* Zhijie Tian,1,* Yuan Qian,1 Xingyu Miao,1 Yuelin Zhang3 1Neurosurgery, Shaanxi Provincial People’s Hospital, Xian, 710068, People’s Republic of China; 2Hengyang Medical School, University of South China, Hengyang ...
Feng P, Li Y, Tian Z, Qian Y, Miao X, Zhang Y   +5 more
doaj  

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Deciphering The Links Between Non-Alcoholic Fatty Liver and Hepatocellular Carcinoma Prognosis: A Weighted Gene Co-Expression Network Analysis Approach

Indonesian Journal of Cancer
Background: Metabolic Associated Fatty Liver Disease (MAFLD) is a common liver disease associated with an increased risk of developing hepatocellular carcinoma (HCC).
Mariam Mahmoud Abady, Amal Magdy
doaj   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Weighted Correlation Network Analysis Reveals CDK2 as a Regulator of a Ubiquitous Environmental Toxin-Induced Cell-Cycle Arrest

Cells, 2020
Environmental food contaminants constitute a threat to human health. For instance, the globally spread mycotoxin Ochratoxin A (OTA) contributes to chronic kidney damage by affecting proximal tubule cells via unknown mechanisms.
Virginie Dubourg, Alexander Nolze, Michael Kopf, Michael Gekle, Gerald Schwerdt   +4 more
doaj   +1 more source

Identification of thyroid cancer biomarkers using WGCNA and machine learning

European Journal of Medical Research
The incidence of thyroid cancer (TC) is increasing in China, largely due to overdiagnosis from widespread screening and improved ultrasound technology. Identifying precise TC biomarkers is crucial for accurate diagnosis and effective treatment.TC patient data were obtained from TCGA.
Gaofeng Hu, Wenyuan Niu, Jiaming Ge, Jie Xuan, Yanyang Liu, Mengjia Li, Huize Shen, Shang Ma, Yuanqiang Li, Qinglin Li   +9 more
openaire   +3 more sources

WGCNA analysis of the subcutaneous fat transcriptome in a novel tree shrew model

Experimental Biology and Medicine, 2020
Obesity involves genetic and environmental factors. The co-expression gene network in relevant tissues in different obesity groups provides an entrance for profiling and identifying associated pathways and genes. We aim to identify the meaningful co-expressed gene network in mRNA extracted from adipose tissues representing different obesity phenotypes ...
Yuanyuan Han, Wenguang Wang, Jie Jia, Xiaomei Sun, Dexuan Kuang, Pinfen Tong, Na Li, Caixia Lu, Huatang Zhang, Jiejie Dai   +9 more
openaire   +3 more sources

The diagnostic value of the circadian rhythm gene KLF10 in anxiety‐depressive disorders and its neuroimmune regulatory mechanisms

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the protective role and molecular mechanism of the circadian rhythm‐related gene KLF10, identified as a diagnostic biomarker and therapeutic target in anxiety‐depressive disorder. Model establishment and phenotypes: An anxiety‐depression model was successfully established by chronic restraint stress combined with ...
Anlan Liu, Weifeng Guo, Jianxiang Li, Tiange Zhang, Dan Xu   +4 more
wiley   +1 more source

Super-Enhancer-Associated Hub Genes In Chronic Myeloid Leukemia Identified Using Weighted Gene Co-Expression Network Analysis

Cancer Management and Research, 2019
Hongying Ma,1,2 Jian Qu,3 Jian Luo,1,2 Tingting Qi,3 Huanmiao Tan,4 Zhaohui Jiang,1 Haiwen Zhang,1 Qiang Qu1,2 1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People’s Republic of China; 2Institute for ...
Ma H, Qu J, Luo J, Qi T, Tan H, Jiang Z, Zhang H, Qu Q   +7 more
doaj  

Histological Characterization and Comparative Transcriptomic Analysis of Gonads During Early Sex Differentiation in the Northern Snakehead (Channa argus)

Animal Research and One Health, EarlyView.
This study delineates the early sex differentiation timeline in the northern snakehead (Channa argus). These findings provide a foundation for future sex‐control breeding in this economically important species. ABSTRACT The northern snakehead (Channa argus) is an economically important aquaculture species in China.
Chaonan Sun, Donglei Sun, Haishen Wen, Xin Qi, Chao Li, Xiaoyan Zhang, Yun Li   +6 more
wiley   +1 more source