Results 41 to 50 of about 33,188 (253)

WGCNA script

, 2015
Script for network analysis of gene expression using the R package WGCNA. The script will require variance stabilized gene expression data for all samples and a table of trait values for each ...
Mikhail V. Matz (51701), Wright, Rachel M., Aglyamova, Galina V., Matz, Mikhail V., Galina V. Aglyamova (3245331), Eli Meyer (248745), Rachel M. Wright (447448), Meyer, Eli   +7 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Eigengene Dendrogram (WGCNA)

, 2014
Dendrogram of eigengenes generated by WGCNA. The eigene gene merge cut-off is shown as a horizontal red line. 
Liz Fernandez (631027)
core   +1 more source

A Novel CsYABBY3‐CsAS1 Feedback Loop Coordinates Trichome Differentiation and Cannabinoid Biosynthesis in Cannabis sativa L.

Advanced Science, EarlyView.
A novel transcriptional module involving CsYABBY3 and CsAS1 is identified to regulate cannabinoid biosynthesis and trichome development. These factors mutually activate each other and form a protein complex via a conserved residue, acting synergistically to amplify metabolic flux through a coordinate feed‐forward mechanism.
Xuewen Zhu, Yaolei Mi, Xue Cao, Weiqiang Chen, Pucheng Fan, Jing Wang, Yiming Zhang, Wei Yang, Huihua Wan, Shanshan Chen, Xiangxiao Meng, Jun Li, Shuo Shen, Mingkun Huang, Xiaoyu Zhang, Ming Luo, Shilin Chen, Zhichao Xu, Wei Sun   +18 more
wiley   +1 more source

Identification of candidate blood biomarkers for the diagnosis of septicaemic melioidosis based on WGCNA

Artificial Cells, Nanomedicine, and Biotechnology, 2022
Melioidosis is an infectious disease caused by Burkholderia pseudomallei (Bp), a gram-negative bacillus. Sepsis is the most prevalent type of melioidosis. Due to factors such as lack of precision and slow presentation of bacterial culture tests, the misdiagnosis rate could exceed 100 per cent.
Li Yin, Yuanyuan Chen, Tingting Fu, Lin Liu, Qianfeng Xia   +4 more
openaire   +3 more sources

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Identification of important modules and biomarkers in tuberculosis based on WGCNA

Frontiers in Microbiology
BackgroundTuberculosis (TB) is a significant public health concern, particularly in China. Long noncoding RNAs (lncRNAs) can provide abundant pathological information regarding etiology and could include candidate biomarkers for diagnosis of TB. However, data regarding lncRNA expression profiles and specific lncRNAs associated with TB are limited ...
Jing Dong, Jing Dong, Jing Dong, Ruixue Song, Ruixue Song, Ruixue Song, Xuetian Shang, Xuetian Shang, Xuetian Shang, Yingchao Wang, Yingchao Wang, Yingchao Wang, Qiuyue Liu, Qiuyue Liu, Zhiguo Zhang, Hongyan Jia, Hongyan Jia, Hongyan Jia, Mailing Huang, Mailing Huang, Chuanzhi Zhu, Chuanzhi Zhu, Chuanzhi Zhu, Qi Sun, Qi Sun, Qi Sun, Boping Du, Boping Du, Boping Du, Aiying Xing, Aiying Xing, Aiying Xing, Zihui Li, Zihui Li, Zihui Li, Lanyue Zhang, Lanyue Zhang, Lanyue Zhang, Liping Pan, Liping Pan, Liping Pan, Zongde Zhang, Zongde Zhang, Zongde Zhang   +43 more
openaire   +3 more sources

Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression

Advanced Science, EarlyView.
The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren, Xiaogang Li, Hao Li, Zenghui Cao, Mengtian Hou, Chunlei Zhao, Nan Lou, Sasa Hu, Yanzhe Li, Qian Ma, Yaoyao Li, Yi Fan, Kunkun Zhao, Kai Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Haitao Liu, Xingli Ma, Xingxiang Wang, Dongmei Yin   +20 more
wiley   +1 more source

Identification the role of necroptosis in rheumatoid arthritis by WGCNA network

Autoimmunity
Rheumatoid arthritis (RA) is the predominant manifestation of inflammatory arthritis, distinguished by an increasing burden of morbidity and mortality. The intricate interplay of genes and signalling pathways involved in synovial inflammation in patients with RA remains inadequately comprehended. This study aimed to ascertain the role of necroptosis in
Feige Nian, Yiwen Wang, Mingfeng Yang, Bin Zhang   +3 more
openaire   +3 more sources

Identification of potential biomarkers for endometrial carcinoma based on WGCNA

, 2022
Abstract Background Endometrial carcinoma (EC) is a group of malignant epithelial tumors occurring in the endometrium. With the increasing incidence of recent years, identifying the molecular mechanisms associated with endometrial carcinoma has become particularly important for the early diagnosis and treatment of cancer. Methods RNA-seq data
Lei Wang, Ying Ma, Zhe Liu, Yu Zhang, Xudong Liu, Yafan Wang, Lijun Zhao, Jinke Fan, Tao Peng, Rui Li, Yuxuan Chen, Xinqiang Song   +11 more
openaire   +1 more source