Results 41 to 50 of about 47,201 (334)

M1 macrophage-related prognostic model by combining bulk and single-cell transcriptomic data in NSCLC [PDF]

Exploration of Medicine
Aim: Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is the most common subtype. Despite recent advancements in diagnostics and therapies, only a small percentage of patients benefit from ...
Zhe Liu, Fang Liu, Olutomilayo Olayemi Petinrin, Muhammad Toseef, Nanjun Chen, Zhongxu Zhu, Ka-Chun Wong   +6 more
doaj   +1 more source

Diel transcriptional response of a California Current plankton microbiome to light, low iron, and enduring viral infection. [PDF]

, 2019
Phytoplankton and associated microbial communities provide organic carbon to oceanic food webs and drive ecosystem dynamics. However, capturing those dynamics is challenging. Here, an in situ, semi-Lagrangian, robotic sampler profiled pelagic microbes at
Allen, AE, Allen, EE, Allen, L Zeigler, Aylward, FO, Chavez, FP, Delong, EF, Fontanez, KM, Kolody, BC, McCrow, JP, Moniruzzaman, M, Moustafa, A, Scholin, CA, Worden, AZ   +12 more
core   +2 more sources

Identification of key pathways and genes in nasopharyngeal carcinoma based on WGCNA

Auris Nasus Larynx, 2023
We aim to identify the potential genes and signaling pathways associated with the nasopharyngeal carcinoma (NPC) prognosis using Weighted Gene Co-Expression Network Analysis (WGCNA).Gene Expression Omnibus (GEO) query was utilized to download two NPC mRNA microarray data.
Yongmei, Dai, Wenhan, Chen, Junpeng, Huang, Li, Xie, Jianfang, Lin, Qianshun, Chen, Guicheng, Jiang, Chen, Huang   +7 more
openaire   +2 more sources

Identification of Gene Co-Expression Modules and Core Genes Related to Immune Disorders in Major Depression Disorder

International Journal of General Medicine, 2021
Lei Zhang,1,* Haibo Zhang,2,* Jiadong Xie,3,* Xu Wang4 1School of Public Administration, Hohai University, Nanjing, People’s Republic of China; 2Organization of Personnel Division, Jiangsu Provincial People’s Hospital (The First Affiliated ...
Zhang L, Zhang H, Xie J, Wang X
doaj  

Peripheral blood gene expression reveals an inflammatory transcriptomic signature in Friedreich's ataxia patients. [PDF]

, 2018
Transcriptional changes in Friedreich's ataxia (FRDA), a rare and debilitating recessive Mendelian neurodegenerative disorder, have been studied in affected but inaccessible tissues-such as dorsal root ganglia, sensory neurons and cerebellum-in animal ...
Coppola, Giovanni, Dokuru, Deepika, Farmer, Jennifer, Gao, Fuying, Isaacs, Charles, Lynch, David R, Nachun, Daniel, Perlman, Susan, Sears, Renee, Strawser, Cassandra, Van Berlo, Victoria, Yang, Zhongan   +11 more
core   +1 more source

Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure [PDF]

, 2019
Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvest 1352 healthy and failing human hearts directly from transplant center operating rooms, and ...
Ashley, Euan A., Bernstein, Daniel, Brandimarto, Jeff, Cappola, Thomas, Chang, Alex C., Chin, Elizabeth T., Connolly, Andrew, Cordero, Pablo, Depaoli-Roach, Anna A., Dewey, Frederick, Erbilgin, Ayca, Glazer, Nicole, Gloudemans, Michael J., Hakonarson, Hakon, Hannenhalli, Sridhar, Huang, Yong, Li, Hongzhe, Li, Mingyao, Lusis, Aldons J., Malloy, Christine, Margulies, Kenneth B., Montgomery, Stephen B., Moravec, Christine S., Morley, Michael, Parikh, Victoria N., Pavlovic, Aleksandra, Ritter, Scott, Shang, Ching, Skreen, Jamie, Smith, Kevin S., Tang, W. H. Wilson, Waggott, Daryl, Wheeler, Matthew T., Zaleta, Kathia, Zhao, Mingming   +34 more
core   +2 more sources

Transcriptomic signatures of neuronal differentiation and their association with risk genes for autism spectrum and related neuropsychiatric disorders. [PDF]

, 2016
Genes for autism spectrum disorders (ASDs) are also implicated in fragile X syndrome (FXS), intellectual disabilities (ID) or schizophrenia (SCZ), and converge on neuronal function and differentiation. The SH-SY5Y neuroblastoma cell line, the most widely
Chiocchetti, AG, Cocchi, E, de la Torre-Ubieta, L, Freitag, CM, Fulda, S, Geschwind, DH, Haslinger, D, Lindlar, S, Rothämel, T, Stein, JL, Waltes, R   +10 more
core   +1 more source

Identification of Underlying Hub Genes Associated with Hypertrophic Cardiomyopathy by Integrated Bioinformatics Analysis

Pharmacogenomics and Personalized Medicine, 2021
Zetao Ma,1,2,* Xizhi Wang,1,* Qingbo Lv,1 Yingchao Gong,1 Minghong Xia,1 Lenan Zhuang,1 Xue Lu,1 Ying Yang,1 Wenbin Zhang,1 Guosheng Fu,1 Yang Ye,1 Dongwu Lai1 1Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang ...
Ma Z, Wang X, Lv Q, Gong Y, Xia M, Zhuang L, Lu X, Yang Y, Zhang W, Fu G, Ye Y, Lai D   +11 more
doaj  

Identification of candidate biomarkers for GBM based on WGCNA

Scientific Reports
AbstractGlioblastoma multiforme (GBM), the most aggressive form of primary brain tumor, poses a considerable challenge in neuro-oncology. Despite advancements in therapeutic approaches, the prognosis for GBM patients remains bleak, primarily attributed to its inherent resistance to conventional treatments and a high recurrence rate. The primary goal of
Qinghui Sun, Zheng Wang, Hao Xiu, Na He, Mingyu Liu, Li Yin   +5 more
openaire   +3 more sources

Identification of Critical Modules and Biomarkers of Ulcerative Colitis by Using WGCNA

Journal of Inflammation Research, 2023
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon and rectum that has no exact cause and is characterized by relapsing and remitting episodes. We aimed to find biomarkers of UC and its causes.We got GSE73661 from the GEO database and used WGCNA to find DEGs that were expressed in the same way in both normal and UC samples.
Yuan,Yifan, Li,Na, Fu,Mingyue, Ye,Mei
openaire   +4 more sources