Results 41 to 50 of about 31,790 (245)

Identification of hub genes and molecular subtypes in COVID-19 based on WGCNA.

European review for medical and pharmacological sciences, 2021
The heterogeneity of clinical manifestations and mortality rates in Coronavirus disease 2019 (COVID-19) patients may be related to the existence of molecular subtypes in COVID-19. To improve current management, it is essential to find the hub genes and pathways associated with different COVID-19 subtypes.The whole-genome sequencing information ...
Hu, R.-W., Liu, C., Yan, Y.-Y., Li, D.
openaire   +2 more sources

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

WGCNA-based identification of potential targets and pathways in response to treatment in locally advanced breast cancer patients

Open Medicine, 2023
Locally advanced breast cancer patients have a poor prognosis; however, the relationship between potential targets and the response to treatment is still unclear.
Zhao Ruipeng, Wei Wan, Zhen Linlin
doaj   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Identification of Unique Transcriptomic Signatures and Hub Genes Through RNA Sequencing and Integrated WGCNA and PPI Network Analysis in Nonerosive Reflux Disease

Journal of Inflammation Research, 2021
Ye Zhao,1,* Teng Ma,2,* Duowu Zou1 1Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China; 2Department of Thoracic Surgery, Zhongshan Hospital, Fudan ...
Zhao Y, Ma T, Zou D
doaj  

Identification of potential key genes affecting soybean growth under salt stress via transcriptome study

Biologia Plantarum, 2020
Soybean is one of the most important economic crops in the world. However, the salinization of soil results in the decrease of soybean yield as it is only a moderately salt-tolerant crop.
N. LI, Z. LI, S. FAN, Y. PU, Y. GONG, R. TIAN, X. GUO, H. DING   +7 more
doaj   +1 more source

Identification of important modules and biomarkers in tuberculosis based on WGCNA

Frontiers in Microbiology
BackgroundTuberculosis (TB) is a significant public health concern, particularly in China. Long noncoding RNAs (lncRNAs) can provide abundant pathological information regarding etiology and could include candidate biomarkers for diagnosis of TB. However, data regarding lncRNA expression profiles and specific lncRNAs associated with TB are limited ...
Jing Dong, Jing Dong, Jing Dong, Ruixue Song, Ruixue Song, Ruixue Song, Xuetian Shang, Xuetian Shang, Xuetian Shang, Yingchao Wang, Yingchao Wang, Yingchao Wang, Qiuyue Liu, Qiuyue Liu, Zhiguo Zhang, Hongyan Jia, Hongyan Jia, Hongyan Jia, Mailing Huang, Mailing Huang, Chuanzhi Zhu, Chuanzhi Zhu, Chuanzhi Zhu, Qi Sun, Qi Sun, Qi Sun, Boping Du, Boping Du, Boping Du, Aiying Xing, Aiying Xing, Aiying Xing, Zihui Li, Zihui Li, Zihui Li, Lanyue Zhang, Lanyue Zhang, Lanyue Zhang, Liping Pan, Liping Pan, Liping Pan, Zongde Zhang, Zongde Zhang, Zongde Zhang   +43 more
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An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Identification the role of necroptosis in rheumatoid arthritis by WGCNA network

Autoimmunity
Rheumatoid arthritis (RA) is the predominant manifestation of inflammatory arthritis, distinguished by an increasing burden of morbidity and mortality. The intricate interplay of genes and signalling pathways involved in synovial inflammation in patients with RA remains inadequately comprehended. This study aimed to ascertain the role of necroptosis in
Feige Nian, Yiwen Wang, Mingfeng Yang, Bin Zhang   +3 more
openaire   +3 more sources

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source