Results 51 to 60 of about 43,312 (289)

Identification of potential biomarkers for endometrial carcinoma based on WGCNA

, 2022
Abstract Background Endometrial carcinoma (EC) is a group of malignant epithelial tumors occurring in the endometrium. With the increasing incidence of recent years, identifying the molecular mechanisms associated with endometrial carcinoma has become particularly important for the early diagnosis and treatment of cancer. Methods RNA-seq data
Lei Wang, Ying Ma, Zhe Liu, Yu Zhang, Xudong Liu, Yafan Wang, Lijun Zhao, Jinke Fan, Tao Peng, Rui Li, Yuxuan Chen, Xinqiang Song   +11 more
openaire   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Transcriptome profiling during double-flower development provides insight into stamen petaloid in cultivated Lilium

Ornamental Plant Research, 2022
Asiatic hybrid lilies (Lilium spp.), as the biggest cultivar groups of the lily variety are an ornamental plant with elegant floral patterns and bright colors.
Wen-Bo Wang, Xiangfeng He, Xiaoying Li, Wenhe Wang   +3 more
doaj   +1 more source

Trypoxylus dichotomus RNA-seq Td11 WGCNA

, 2022
WGCNA analysis of Trypoxylus dichotomus RNA-seq Td11 data set (doi: 10.6084/m9.figshare.17126315).3 files are includedMMPvalue.txtgeneModuleMembership.txtmodule_names.txtWGCNA program outputs module names as color names such as turquoise and salmon.
Shuji Shigenobu (5769491)
core   +1 more source

Identification of candidate blood biomarkers for the diagnosis of septicaemic melioidosis based on WGCNA

Artificial Cells, Nanomedicine, and Biotechnology, 2022
Melioidosis is an infectious disease caused by Burkholderia pseudomallei (Bp), a gram-negative bacillus. Sepsis is the most prevalent type of melioidosis. Due to factors such as lack of precision and slow presentation of bacterial culture tests, the misdiagnosis rate could exceed 100 per cent.
Li Yin, Yuanyuan Chen, Tingting Fu, Lin Liu, Qianfeng Xia   +4 more
openaire   +3 more sources

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Eigengene Dendrogram (WGCNA)

, 2014
Dendrogram of eigengenes generated by WGCNA. The eigene gene merge cut-off is shown as a horizontal red line. 
Liz Fernandez (631027)
core   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

WGCNA-based identification of potential targets and pathways in response to treatment in locally advanced breast cancer patients

Open Medicine, 2023
Locally advanced breast cancer patients have a poor prognosis; however, the relationship between potential targets and the response to treatment is still unclear.
Zhao Ruipeng, Wei Wan, Zhen Linlin
doaj   +1 more source