Results 51 to 60 of about 47,201 (334)

Transcriptome profiling during double-flower development provides insight into stamen petaloid in cultivated Lilium

Ornamental Plant Research, 2022
Asiatic hybrid lilies (Lilium spp.), as the biggest cultivar groups of the lily variety are an ornamental plant with elegant floral patterns and bright colors.
Wen-Bo Wang, Xiangfeng He, Xiaoying Li, Wenhe Wang   +3 more
doaj   +1 more source

Stability Indicators in Network Reconstruction [PDF]

, 2012
The number of algorithms available to reconstruct a biological network from a dataset of high-throughput measurements is nowadays overwhelming, but evaluating their performance when the gold standard is unknown is a difficult task. Here we propose to use
Filosi, Michele, Furlanello, Cesare, Jurman, Giuseppe, Riccadonna, Samantha, Visintainer, Roberto   +4 more
core  

Co-expression networks in generation of induced pluripotent stem cells. [PDF]

, 2016
We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for
Coppola, Giovanni, Dansithong, Warunee, Figueroa, Karla P, Gao, Fuying, Paul, Sharan, Pflieger, Lance, Pulst, Stefan M   +6 more
core   +2 more sources

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Weighted Correlation Network Analysis (WGCNA) Applied to the Tomato Fruit Metabolome

PLoS ONE, 2011
Advances in "omics" technologies have revolutionized the collection of biological data. A matching revolution in our understanding of biological systems, however, will only be realized when similar advances are made in informatic analysis of the resulting "big data." Here, we compare the capabilities of three conventional and novel statistical ...
Matthew V DiLeo, Gary D Strahan, Meghan den Bakker, Owen A Hoekenga   +3 more
openaire   +4 more sources

Identification of potential biomarkers for endometrial carcinoma based on WGCNA

, 2022
Abstract Background Endometrial carcinoma (EC) is a group of malignant epithelial tumors occurring in the endometrium. With the increasing incidence of recent years, identifying the molecular mechanisms associated with endometrial carcinoma has become particularly important for the early diagnosis and treatment of cancer. Methods RNA-seq data
Lei Wang, Ying Ma, Zhe Liu, Yu Zhang, Xudong Liu, Yafan Wang, Lijun Zhao, Jinke Fan, Tao Peng, Rui Li, Yuxuan Chen, Xinqiang Song   +11 more
openaire   +1 more source

Identification of susceptibility modules and hub genes of osteoarthritis by WGCNA analysis

Frontiers in Genetics, 2022
Osteoarthritis (OA) is a major cause of pain, disability, and social burden in the elderly throughout the world. Although many studies focused on the molecular mechanism of OA, its etiology remains unclear. Therefore, more biomarkers need to be explored to help early diagnosis, clinical outcome measurement, and new therapeutic target development.
Yanchao Wang, Wenjun Zhou, Wenjun Zhou, Wenjun Zhou, Yan Chen, Dong He, Zhen Qin, Zhao Wang, Zhao Wang, Song Liu, Song Liu, Lei Zhou, Lei Zhou, Lei Zhou, Jianwen Su, Jianwen Su, Jianwen Su, Chi Zhang, Chi Zhang, Chi Zhang   +19 more
openaire   +3 more sources

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

ACT2.6: Global Gene Coexpression Network in Arabidopsis thaliana Using WGCNA

Genes
Background/Objectives: Genes with similar expression patterns across multiple samples are considered coexpressed, and they may participate in similar biological processes or pathways. Gene coexpression networks depict the degree of similarity between the expression profiles of all genes in a set of samples.
Vasileios L. Zogopoulos, Konstantinos Papadopoulos, Apostolos Malatras, Vassiliki A. Iconomidou, Ioannis Michalopoulos   +4 more
openaire   +3 more sources

The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus. [PDF]

, 2020
Filamentous fungi, such as Neurospora crassa, are very efficient in deconstructing plant biomass by the secretion of an arsenal of plant cell wall-degrading enzymes, by remodeling metabolism to accommodate production of secreted enzymes, and by enabling ...
Benz, J Philipp, Blow, Matthew J, Calhoun, Sara, Dietschmann, Axel, Glass, N Louise, Grigoriev, Igor V, Huberman, Lori B, Kowbel, David J, Lee, Juna, Lipzen, Anna, Monti, Remo, O'Malley, Ronan C, Singan, Vasanth R, Thieme, Nils, Wu, Vincent W, Xiong, Yi   +15 more
core   +3 more sources