Results 21 to 30 of about 33,188 (253)
WGCNA combined with GSVA to explore biomarkers of refractory neocortical epilepsy
IBRO Neuroscience Reports, 2022 About two-thirds of epilepsy patients relapse within five years after surgery. It is significant to note that the limitations of current treatments stem from a lack of understanding of molecular mechanisms. In this study, Weighted Gene Co-expression Network Analysis (WGCNA) and Gene set variation analysis (GSVA) methods were used to analyze the total ...
Rui Zhang +5 more
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WGCNA and molecular docking identify hub genes for cardiac aging
Frontiers in Cardiovascular Medicine, 2023 BackgroundCardiac aging and ageing-related cardiovascular diseases remain increase medical and social burden. Discovering the molecular mechanisms associated with cardiac aging is expected to provide new perspectives for delaying aging and related disease treatment.MethodsThe samples in GEO database were divided into older group and younger group based
Ping Ping +8 more
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Identification of Critical Modules and Biomarkers of Ulcerative Colitis by Using WGCNA
Journal of Inflammation Research, 2023 Ulcerative colitis (UC) is a chronic inflammatory disease of the colon and rectum that has no exact cause and is characterized by relapsing and remitting episodes. We aimed to find biomarkers of UC and its causes.We got GSE73661 from the GEO database and used WGCNA to find DEGs that were expressed in the same way in both normal and UC samples.
Yuan,Yifan, Li,Na, Fu,Mingyue, Ye,Mei
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Identification of early diagnostic biomarkers via WGCNA in gastric cancer
Biomedicine & Pharmacotherapy, 2022 Gastric cancer (GC) is the world's second-leading cause of cancer-related mortality, continuing to make it a serious healthcare concern. Even though the prevalence of GC reduces, the prognosis for GC patients remains poor in terms of a lack of reliable biomarkers to diagnose early GC and predict chemosensitivity and recurrence.We integrated the gene ...
Rezaei Z. +9 more
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Identification of susceptibility modules and hub genes of osteoarthritis by WGCNA analysis
Frontiers in Genetics, 2022 Osteoarthritis (OA) is a major cause of pain, disability, and social burden in the elderly throughout the world. Although many studies focused on the molecular mechanism of OA, its etiology remains unclear. Therefore, more biomarkers need to be explored to help early diagnosis, clinical outcome measurement, and new therapeutic target development.
Yanchao Wang +19 more
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Identification of therapeutic targets and prognostic biomarkers in cholangiocarcinoma via WGCNA
Frontiers in Oncology, 2022 BackgroundCholangiocarcinoma (CCA) is a highly aggressive malignant tumor for which limited treatment methods and prognostic signatures are available. This study aims to identify potential therapeutic targets and prognostic biomarkers for CCA.MethodsBased on differentially expressed genes (DEGs) identified from The Cancer Genome Atlas (TCGA) data, our ...
Lei Xu, Ting Xiao, Ling Xu, Wei Yao
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Identification of crucial genes in abdominal aortic aneurysm by WGCNA
PeerJ, 2019 Background Abdominal aortic aneurysm (AAA) is the full thickness dilation of the abdominal aorta. However, few effective medical therapies are available. Thus, elucidating the molecular mechanism of AAA pathogenesis and exploring the potential molecular target of medical therapies for AAA is of vital importance.
Siliang Chen +7 more
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Identification of Important Modules and Biomarkers in Breast Cancer Based on WGCNA.
OncoTargets and therapy, 2020 Breast cancer (BRCA) has the highest incidence among female malignancies, and the prognosis for these patients remains poor.In this study, core modules and central genes related to BRCA were identified through a weighted gene co-expression network analysis (WGCNA).
Tian,Zelin +6 more
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Identification of the role of pyroptosis -related genes in chronic rhinosinusitis based on WGCNA
Heliyon, 2023 Abstract Background: Chronic rhinosinusitis (CRS) is a complex chronic inflammatory disease of the nose, paranasal sinus, and upper respiratory tract. Its treatment methods mainly include antibiotic treatment and surgical treatment. However, the molecular mechanism of its inflammation is still unclear. Pyroptosis is a programmed cell death.
Yarui Wan +4 more
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Identification of Latent Diagnostic Biomarkers and Biological Pathways in Dermatomyositis Based on WGCNA [PDF]
Journal of Oncology, 2021 Introduction. Dermatomyositis (DM) is a chronic autoimmune disease of predominantly lymphocytic infiltration mainly involving the transverse muscle. Its pathogenesis is remaining unknown. This research is designed to probe the latent pathogenesis of dermatomyositis, identify potential biomarkers, and reveal the pathogenesis of dermatomyositis through ...
Shaxi Ouyang +6 more
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