Results 11 to 20 of about 33,188 (253)

WGCNA: an R package for weighted correlation network analysis [PDF]

BMC Bioinformatics, 2008
Background Correlation networks are increasingly being used in bioinformatics applications. For example, weighted gene co-expression network analysis is a systems biology method for describing the correlation patterns among genes across microarray ...
Langfelder Peter, Horvath Steve
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Identification and Analysis of Potential Autophagy-Related Biomarkers in Endometriosis by WGCNA [PDF]

Frontiers in Molecular Biosciences, 2021
Background: Endometriosis is a serious gynecological disorder characterized by debilitating pain, infertility and the establishment of innervated endometriosis lesions outside the uterus. Early detection and accurate diagnosis are pivotal in endometriosis.
Jing Wang, Shanshan Cong, Han Wu, Yanan He, Xiaoli Liu, Liyuan Sun, Xibo Zhao, Guangmei Zhang   +7 more
openaire   +3 more sources

Identification of key genes in sepsis by WGCNA

Preventive Medicine, 2023
When the body damages its own tissues in response to an infection, sepsis develops. Medical treatments are limited. It's important to understand the molecular mechanism behind sepsis pathogenesis and identify potential molecular treatment targets. We made two modules based on how genes work together by using WGCNA analysis.
Xue-Meng, Gao, Xiu-Hua, Zhou, Meng-Wei, Jia, Xiao-Zhuo, Wang, Dan, Liu   +4 more
openaire   +2 more sources

WGCNA Identifies Translational and Proteasome-Ubiquitin Dysfunction in Rett Syndrome [PDF]

International Journal of Molecular Sciences, 2021
Rett Syndrome (RTT) is an X linked neurodevelopmental disorder caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene, resulting in severe cognitive and physical disabilities. Despite an apparent normal prenatal and postnatal development period, symptoms usually present around 6 to 18 months of age.
Florencia Haase, Brian S. Gloss, Patrick P. L. Tam, Wendy A. Gold   +3 more
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WGCNA revisited: Module indetification

Journal of Physics: Conference Series, 2021
Abstract WGCNA is a very popular R language software package used in biomedical field. It is mainly designed to deal with gene microarray samples to find clusters (modules), which include highly correlated genes, in biomedical studies. Theoretically, it results in the hierarchical modules, which are different from the results based on ...
Shaomin Yan, Guang Wu
openaire   +1 more source

ACT2.6: Global Gene Coexpression Network in Arabidopsis thaliana Using WGCNA

Genes
Background/Objectives: Genes with similar expression patterns across multiple samples are considered coexpressed, and they may participate in similar biological processes or pathways. Gene coexpression networks depict the degree of similarity between the
Ioannis Michalopoulos, Vassiliki A. Iconomidou, Apostolos Malatras, Vasileios L. Zogopoulos, Konstantinos Papadopoulos   +4 more
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Identification of key pathways and genes in nasopharyngeal carcinoma based on WGCNA

Auris Nasus Larynx, 2023
We aim to identify the potential genes and signaling pathways associated with the nasopharyngeal carcinoma (NPC) prognosis using Weighted Gene Co-Expression Network Analysis (WGCNA).Gene Expression Omnibus (GEO) query was utilized to download two NPC mRNA microarray data.
Yongmei, Dai, Wenhan, Chen, Junpeng, Huang, Li, Xie, Jianfang, Lin, Qianshun, Chen, Guicheng, Jiang, Chen, Huang   +7 more
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RETRACTED: Identification of Early Diagnostic and Prognostic Biomarkers via WGCNA in Stomach Adenocarcinoma [PDF]

Frontiers in Oncology, 2021
Stomach adenocarcinoma (STAD) is a leading cause of cancer deaths, and the outcome of the patients remains dismal for the lack of effective biomarkers of early detection. Recent studies have elucidated the landscape of genomic alterations of gastric cancer and reveal some biomarkers of advanced-stage gastric cancer, however, information about early ...
Ruoyue Tan, Ruoyue Tan, Ruoyue Tan, Guanghui Zhang, Guanghui Zhang, Ruochen Liu, Ruochen Liu, Jianbing Hou, Jianbing Hou, Zhen Dong, Zhen Dong, Chaowei Deng, Chaowei Deng, Sicheng Wan, Sicheng Wan, Xiaodong Lai, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui   +18 more
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WGCNA Identification of Genes and Pathways Involved in the Pathogenesis of Postmenopausal Osteoporosis

International Journal of General Medicine, 2021
Postmenopausal osteoporosis (PMO) patients may suffer from chronic pain and increased fractures due to brittle bones that seriously affect their normal work and life. Exploring the pathogenesis of PMO can help clinicians construct individualized therapeutic targets.Differentially expressed genes (DEGs) were identified by analyzing the microarray assays
Meng-Lei Hao, Xiao-Qin Zuo, Yong Qiu, Jian Li   +3 more
openaire   +4 more sources

Identification of Survival-Associated Hub Genes in Pancreatic Adenocarcinoma Based on WGCNA [PDF]

Frontiers in Genetics, 2022
Pancreatic adenocarcinoma is one of the leading causes of cancer-related death worldwide. Since little clinical symptoms were shown in the early period of pancreatic adenocarcinoma, most patients were found to carry metastases when diagnosis. The lack of effective diagnosis biomarkers and therapeutic targets makes pancreatic adenocarcinoma difficult to
Liya Huang, Ting Ye, Jingjing Wang, Xiaojing Gu, Ruiting Ma, Lulu Sheng, Binwu Ma   +6 more
openaire   +3 more sources