Results 91 to 100 of about 31,790 (245)

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Plac8 regulates the fibrogenic ability of cardiac fibroblasts in mice with myocardial infarction

All Life
Cardiac fibroblasts (CFs) are of vital importance for post-myocardial infarction (MI) remodeling. This study explored the role of Placenta specific 8 (Plac8) in MI on the basis of single-cell RNA-Seq (scRNA-Seq) data (GSE136088) and micro-array data ...
Ting Fu, Jianping Gong, Lei Xu, Ningning Ji   +3 more
doaj   +1 more source

Identification of four hub genes associated with adrenocortical carcinoma progression by WGCNA

PeerJ, 2019
Background Adrenocortical carcinoma (ACC) is a rare and aggressive malignant cancer in the adrenal cortex with poor prognosis. Though previous research has attempted to elucidate the progression of ACC, its molecular mechanism remains poorly understood ...
Wang-Xiao Xia, Qin Yu, Gong-Hua Li, Yao-Wen Liu, Fu-Hui Xiao, Li-Qin Yang, Zia Ur Rahman, Hao-Tian Wang, Qing-Peng Kong   +8 more
openaire   +3 more sources

Inter‐tissue relationships of gene expression in liver, muscle and adipose tissue of children with end‐stage chronic liver disease

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives End‐stage chronic liver disease in children is associated with sarcopenia and aberrant adipose tissue mass. We investigated correlations between liver pathology‐associated gene pathways (fibrosis, inflammation and steatosis) and metabolic genes in muscle and adipose tissue.
Eirini Kyrana, Cheng Zhang, Han Jin, Siamak Salehi, Jonathan C. K. Wells, Maesha Deheragoda, Ragai R. Mitry, Anil Dhawan   +7 more
wiley   +1 more source

FOXC1: A Key Transcription Factor of VSMC‐Derived Foam Cell Formation in Atherosclerotic Plaque Instability

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The instability of atherosclerotic plaques, particularly intraplaque hemorrhage (IPH), drives life‐threatening cardiovascular events, a process in which vascular smooth muscle cell (VSMC)‐derived foam cells play a significant role. We aim to identify key biomarkers associated with VSMC‐derived foam cells and IPH by analyzing data from human ...
Ling‐Lin Qian, Xue‐Ling Li, Li‐Hong Wang, Wei Yang, Yu Jiang   +4 more
wiley   +1 more source

Potential Novel Modules and Hub Genes as Prognostic Candidates of Thyroid Cancer by Weighted Gene Co-Expression Network Analysis

International Journal of General Medicine, 2021
Zhiqiang Shi,1 Xinghui Li,2 Long Zhang,1 Yilang Luo,1 Bikal Shrestha,3 Xuegang Hu1 1Department of Stomatology, University of Chinese Academy of Sciences - Shenzhen Hospital, Shenzhen, Guangdong, 518107, People’s Republic of China; 2Department of ...
Shi Z, Li X, Zhang L, Luo Y, Shrestha B, Hu X   +5 more
doaj  

Single‐Cell Transcriptomics and Deep Learning Link N‐(2‐Furoyl) Glycine to GLRX3 in Gastric Cancer

Med Research, EarlyView.
ABSTRACT Gastric cancer remains a health burden, and its metabolic drivers are poorly defined. N‐(2‐furoyl) glycine, a circulating metabolite, has been implicated in tumor biology. We investigated its causal role in gastric cancer and the underlying mechanism.
Yingyi Zhang, Chenchen Wang, Tianliang Liu, Ziliang Wang, Zhe Zhang   +4 more
wiley   +1 more source

Exploring the Relevance of Disulfidptosis to the Pathophysiology of Ulcerative Colitis by Bioinformatics Analysis

Journal of Inflammation Research
Zhe Xiong,1,2 Ying Fang,1,2 Shuangshuang Lu,1 Qiuyue Sun,1,3 Yuhui Sun,1,3 Pengcheng Yang,4,* Jin Huang1,* 1Department of Gastroenterology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu Province,
Xiong Z, Fang Y, Lu S, Sun Q, Sun Y, Yang P, Huang J   +6 more
doaj  

Identification of CIRBP and TRPV4 as Immune-Related Diagnostic Biomarkers in Osteoarthritis

International Journal of General Medicine, 2021
Chengyang Tang,1,* Qiang Liu,2,* Yaxuan Zhang,1 Guihu Liu,1 Guangsi Shen1 1Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Institution of Sports Medicine, Peking University ...
Tang C, Liu Q, Zhang Y, Liu G, Shen G
doaj  

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source