Results 101 to 110 of about 45,444 (316)

Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages. [PDF]

, 2015
To elucidate the transcriptional 'landscape' that regulates human lymphoid commitment during postnatal life, we used RNA sequencing to assemble the long non-coding transcriptome across human bone marrow and thymic progenitor cells spanning the earliest ...
Casero, David, Crooks, Gay M, Ha, Vi Luan, Luong, Annie, Parekh, Chintan, Sandoval, Salemiz, Scholes, Jessica, Seet, Christopher S, Zhu, Yuhua   +8 more
core  

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset

Annals of Neurology, EarlyView.
Objectives Multiple sclerosis (MS) onset risk factors include Epstein–Barr virus (EBV) indices (including host response), lower serum 25‐vitamin D (25(OH)D) levels, low sun exposure, and HLA‐DRB1*1501. The underlying molecular mechanisms are unclear. Here, we examined mediation through differential DNA methylation (DNAm) to better understand possible ...
Steve Simpson‐Yap, Ellen Morwitch, Samuel A. Tanner, Sarah M. Thomson, Alex Eisner, Rod A. Lea, Trevor J. Kilpatrick, Jeannette Lechner‐Scott, Rodney J. Scott, Alexandre Xavier, Vicki E. Maltby, Robyn M. Lucas, Bruce V. Taylor, Brett A. Lidbury, Simon A. Broadley, Ingrid van der Mei, Mehari Woldemariam Merid, Boris Novakovic, Richard Saffery, Anna Karin Hedström, Pernilla Stridh, Tomas Olsson, Maja Jagodic, Lars Alfredsson, Anne‐Louise Ponsonby, for the Ausimmune Investigator Group, Caron Chapman, Alan Coulthard, Keith Dear, Terry Dwyer, Trevor Kilpatrick, Robyn Lucas, Tony McMichael, Anne‐Louise Ponsonby, Bruce Taylor, Patricia Valery, Ingrid van der Mei, David Williams   +37 more
wiley   +1 more source

SPSB4 as a risk factor for papillary thyroid cancer: Enhancing cell vitality under excess iodine exposure

Frigid Zone Medicine
The varying environmental exposure to iodine has long been a topic of interest, particularly given the noticeable increase in the incidence of papillary thyroid carcinoma (PTC) compared to other histopathological subtypes globally.
Zhang Zhiwei, Long Yongjin, Li Ming, Lyu Chunpeng, Chen Xianglan, Wang Qiaoyu, Yang Kunying, Li Jiahui, Zhang Wei, Sun Dianjun   +9 more
doaj   +1 more source

Identification the role of necroptosis in rheumatoid arthritis by WGCNA network

Autoimmunity
Rheumatoid arthritis (RA) is the predominant manifestation of inflammatory arthritis, distinguished by an increasing burden of morbidity and mortality. The intricate interplay of genes and signalling pathways involved in synovial inflammation in patients with RA remains inadequately comprehended. This study aimed to ascertain the role of necroptosis in
Feige Nian, Yiwen Wang, Mingfeng Yang, Bin Zhang   +3 more
openaire   +3 more sources

Molecular stratification of antiphospholipid syndrome through integrative analysis of the whole‐blood RNA transcriptome

Arthritis &Rheumatology, Accepted Article.
Objective Antiphospholipid syndrome (APS) is a thrombo‐inflammatory disorder characterized by clinical and mechanistic heterogeneity that complicates early diagnosis and hinders targeted treatment. We aimed to identify distinct molecular endotypes among antiphospholipid antibody (aPL)‐positive patients using whole‐blood transcriptomics.
Amala Ambati, Feiyang Ma, Katarina Kmetova, Sherwin Navaz, Claire K. Hoy, Cyrus Sarosh, Ajay Tambralli, Erika Navarro‐Mendoza, Johann E. Gudjonsson, J. Michelle Kahlenberg, Jacqueline A. Madison, Alí Duarte‐García, Jason S. Knight, Yu Zuo   +13 more
wiley   +1 more source

Gene Co-Expression Analysis Identified Preserved and Survival-Related Modules in Severe Blunt Trauma, Burns, Sepsis, and Systemic Inflammatory Response Syndrome

International Journal of General Medicine, 2021
Jingrui Huo,1,* Lei Wang,2,* Yi Tian,2 Wenjie Sun,1 Guoan Zhang,1 Yan Zhang,1 Ying Liu,1 Jingjing Zhang,1 Xiaohui Yang,1 Yingfu Liu3 1Science and Technology Experiment Center, Cangzhou Medical College, Cangzhou, 061001, People’s Republic of China;
Huo J, Wang L, Tian Y, Sun W, Zhang G, Zhang Y, Liu Y, Zhang J, Yang X, Liu Y   +9 more
doaj  

Colon cancer recurrence-associated genes revealed by WGCNA co-expression network analysis

Molecular Medicine Reports, 2017
The present study aimed to identify the recurrence‑associated genes in colon cancer, which may provide theoretical evidence for the development of novel methods to prevent tumor recurrence. Colon cancer and matched normal samples microarray data (E‑GEOD‑39582) were downloaded from ArrayExpress. Genes with significant variation were identified, followed
Zhai, Xiaofeng, Xue, Qingfeng, Liu, Qun, Guo, Yuyu, Chen, Zhe   +4 more
openaire   +3 more sources

Predicting cervical cancer DNA methylation from genetic data using multivariate CMMP

Canadian Journal of Statistics, EarlyView.
Abstract Epigenetic modifications link the environment to gene expression and play a crucial role in tumour development. DNA methylation, in particular, is gaining attention in cancer research, including cervical cancer, the focus of this study.
Hang Zhang, Steven Chen, Raymond Balise, Jiming Jiang, Nagi Ayad, J. Sunil Rao   +5 more
wiley   +1 more source

Identification of the Potential Prognosis Biomarkers in Hepatocellular Carcinoma: An Analysis Based on WGCNA and PPI

International Journal of General Medicine, 2021
Junting Huang,1,* Yating Zhan,1,* Lili Jiang,1,* Yuxiang Gao,1,* Binyu Zhao,1,* Yuxiao Zhang,1 Wenjie Zhang,1 Jianjian Zheng,1 Jinglu Yu2,3 1Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First ...
Huang J, Zhan Y, Jiang L, Gao Y, Zhao B, Zhang Y, Zhang W, Zheng J, Yu J   +8 more
doaj  

Gut microbial features can predict host phenotype response to protein deficiency. [PDF]

, 2018
Malnutrition remains a major health problem in low- and middle-income countries. During low protein intake, <0.67 g/kg/day, there is a loss of nitrogen (N2 ) balance, due to the unavailability of amino acid for metabolism and unbalanced protein ...
Dugas, Lara R, Forrester, Terrence, Gilbert, Jack A, Layden, Brian T, Navarro, Guadalupe, Sharma, Anukriti   +5 more
core