Results 11 to 20 of about 44,952 (245)

WGCNA Identifies Translational and Proteasome-Ubiquitin Dysfunction in Rett Syndrome [PDF]

International Journal of Molecular Sciences, 2021
Rett Syndrome (RTT) is an X linked neurodevelopmental disorder caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene, resulting in severe cognitive and physical disabilities. Despite an apparent normal prenatal and postnatal development period, symptoms usually present around 6 to 18 months of age.
Florencia Haase, Brian Gloss, Patrick Tam, Wendy Gold   +3 more
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WGCNA revisited: Module indetification [PDF]

Journal of Physics: Conference Series, 2021
Abstract WGCNA is a very popular R language software package used in biomedical field. It is mainly designed to deal with gene microarray samples to find clusters (modules), which include highly correlated genes, in biomedical studies. Theoretically, it results in the hierarchical modules, which are different from the results based on ...
Shaomin Yan, Guang Wu
openalex   +2 more sources

ACT2.6: Global Gene Coexpression Network in Arabidopsis thaliana Using WGCNA [PDF]

Genes
Background/Objectives: Genes with similar expression patterns across multiple samples are considered coexpressed, and they may participate in similar biological processes or pathways. Gene coexpression networks depict the degree of similarity between the expression profiles of all genes in a set of samples.
Vasileios L. Zogopoulos, Konstantinos Papadopoulos, Apostolos Malatras, Vassiliki A. Iconomidou, Ioannis Michalopoulos   +4 more
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Identification of key genes in sepsis by WGCNA

Preventive Medicine, 2023
When the body damages its own tissues in response to an infection, sepsis develops. Medical treatments are limited. It's important to understand the molecular mechanism behind sepsis pathogenesis and identify potential molecular treatment targets. We made two modules based on how genes work together by using WGCNA analysis.
Xue-Meng, Gao, Xiu-Hua, Zhou, Meng-Wei, Jia, Xiao-Zhuo, Wang, Dan, Liu   +4 more
openaire   +2 more sources

Identification and Analysis of Potential Autophagy-Related Biomarkers in Endometriosis by WGCNA [PDF]

Frontiers in Molecular Biosciences, 2021
Background: Endometriosis is a serious gynecological disorder characterized by debilitating pain, infertility and the establishment of innervated endometriosis lesions outside the uterus. Early detection and accurate diagnosis are pivotal in endometriosis.
Jing Wang, Shanshan Cong, Han Wu, Yanan He, Xiaoli Liu, Liyuan Sun, Xibo Zhao, Guangmei Zhang   +7 more
openaire   +3 more sources

Identification of early diagnostic biomarkers via WGCNA in gastric cancer

Biomedicine & Pharmacotherapy, 2022
Gastric cancer (GC) is the world's second-leading cause of cancer-related mortality, continuing to make it a serious healthcare concern. Even though the prevalence of GC reduces, the prognosis for GC patients remains poor in terms of a lack of reliable biomarkers to diagnose early GC and predict chemosensitivity and recurrence.We integrated the gene ...
Rezaei Z., Ranjbaran J., Safarpour H., Nomiri S., Salmani F., Chamani E., Larki P., Brunetti O., Silvestris N., Tavakoli T.   +9 more
openaire   +3 more sources

WGCNA and molecular docking identify hub genes for cardiac aging

Frontiers in Cardiovascular Medicine, 2023
BackgroundCardiac aging and ageing-related cardiovascular diseases remain increase medical and social burden. Discovering the molecular mechanisms associated with cardiac aging is expected to provide new perspectives for delaying aging and related disease treatment.MethodsThe samples in GEO database were divided into older group and younger group based
Ping Ping, Lixun Guan, Chaoxue Ning, Qiong Liu, Yali Zhao, Xiang Zhu, Ting Yang, Shihui Fu, Shihui Fu   +8 more
openaire   +3 more sources

Identification of Survival-Associated Hub Genes in Pancreatic Adenocarcinoma Based on WGCNA [PDF]

Frontiers in Genetics, 2022
Pancreatic adenocarcinoma is one of the leading causes of cancer-related death worldwide. Since little clinical symptoms were shown in the early period of pancreatic adenocarcinoma, most patients were found to carry metastases when diagnosis. The lack of effective diagnosis biomarkers and therapeutic targets makes pancreatic adenocarcinoma difficult to
Liya Huang, Ting Ye, Jingjing Wang, Xiaojing Gu, Ruiting Ma, Lulu Sheng, Binwu Ma   +6 more
openaire   +3 more sources

RETRACTED: Identification of Early Diagnostic and Prognostic Biomarkers via WGCNA in Stomach Adenocarcinoma [PDF]

Frontiers in Oncology, 2021
Stomach adenocarcinoma (STAD) is a leading cause of cancer deaths, and the outcome of the patients remains dismal for the lack of effective biomarkers of early detection. Recent studies have elucidated the landscape of genomic alterations of gastric cancer and reveal some biomarkers of advanced-stage gastric cancer, however, information about early ...
Ruoyue Tan, Ruoyue Tan, Ruoyue Tan, Guanghui Zhang, Guanghui Zhang, Ruochen Liu, Ruochen Liu, Jianbing Hou, Jianbing Hou, Zhen Dong, Zhen Dong, Chaowei Deng, Chaowei Deng, Sicheng Wan, Sicheng Wan, Xiaodong Lai, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui   +18 more
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Identification of therapeutic targets and prognostic biomarkers in cholangiocarcinoma via WGCNA

Frontiers in Oncology, 2022
BackgroundCholangiocarcinoma (CCA) is a highly aggressive malignant tumor for which limited treatment methods and prognostic signatures are available. This study aims to identify potential therapeutic targets and prognostic biomarkers for CCA.MethodsBased on differentially expressed genes (DEGs) identified from The Cancer Genome Atlas (TCGA) data, our ...
Lei Xu, Ting Xiao, Ling Xu, Wei Yao
openaire   +3 more sources