Results 211 to 220 of about 57,794 (383)

Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model

British Journal of Pharmacology, EarlyView.
In this study, nintedanib reduced lung fibrosis in a rat double‐hit bleomycin‐induced model. Transcriptomic analysis revealed two key gene signatures related to the effect of the molecule: one involving mesenchymal cells affecting known fibrotic pathways and another linking mainly macrophages to lipid metabolism.
Martina Bonatti, Vanessa Pitozzi, Paola Caruso, Silvia Pontis, Maria Gloria Pittelli, Caterina Frati, Denise Madeddu, Federico Quaini, Costanza Anna Maria Lagrasta, Ilaria Minato, Emanuela Bocchi, Maurizio Civelli, Gino Villetti, Marcello Trevisani, Barbara Montanini   +14 more
wiley   +1 more source

Analysis of the Potential Link Between Dermatomyositis and Cancer

Journal of Inflammation Research
Jianwei Guo,1,2,* Tianyi Lei,1,3,* Xiang Yu,1,3 Peng Wang,1,2 Hongyuan Xie,1,3 Guilin Jian,1,4 Quanbo Zhang,1,2,* Yufeng Qing1,3 1Research Center of Hyperuricemia and Gout, Affiliated Hospital of North Sichuan Medical College, Nanchong ...
Guo J, Lei T, Yu X, Wang P, Xie H, Jian G, Zhang Q, Qing Y   +7 more
doaj  

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

Map-based cloning and WGCNA uncover the key genes controlling cold tolerance in maize introgression lines seedlings [PDF]

, 2022
Ruyu He, Junjun Zheng, Tao Yang, Zeyang Pan, Yang Zhou, Mingjun Cheng, Xiaofeng Li, Yingzheng Li, Chunyan Yang, Muhammad Zafar Iqba, Jianmei He, Tingzhao Rong, Qilin Tang   +12 more
openalex   +1 more source

Inhibition of Fibroblast Activation Protein‐α Ameliorates Intervertebral Disc Degeneration via Reduced Vascular Invasion in Cartilage Endplate

Cell Proliferation, EarlyView.
Schematic illustration showing that FAP‐α promoted angiogenesis, cytokine release and ECM degradation in the CEP degeneration of the intervertebral disc through upregulating the PI3K/Akt/HIF‐1α/VEGFA pathway. ABSTRACT Intervertebral disc degeneration (IDD) is a primary cause of low back pain, with the development of new blood vessels being a key ...
Hao‐Wei Xu, Sheng‐Jie Chang, Shuo Wang, Xiao‐Wei Liu, Shan‐Jin Wang   +4 more
wiley   +1 more source

Whole Blood Transcriptomic Analysis of Sickle Cell Trait

European Journal of Haematology, EarlyView.
ABSTRACT Sickle cell trait (SCT) is the heterozygous carrier state for the HBB missense variant which causes sickle cell disease (SCD). SCT has been associated with increased risk of venous thromboembolism and chronic kidney disease as well as alterations in clinical laboratory parameters. To investigate differential gene expression in SCT, we used RNA
Mari Johnson, Yanwei Cai, Ana Gabriela Vasconcelos, Peter Orchard, Paul L. Auer, Guillaume Lettre, Jia Wen, Nora Franceschini, Charles Kooperberg, Wei Sun, Li Hsu, Laura M. Raffield, Alex P. Reiner   +12 more
wiley   +1 more source

Plac8 regulates the fibrogenic ability of cardiac fibroblasts in mice with myocardial infarction

All Life
Cardiac fibroblasts (CFs) are of vital importance for post-myocardial infarction (MI) remodeling. This study explored the role of Placenta specific 8 (Plac8) in MI on the basis of single-cell RNA-Seq (scRNA-Seq) data (GSE136088) and micro-array data ...
Ting Fu, Jianping Gong, Lei Xu, Ningning Ji   +3 more
doaj   +1 more source

Retracted: High-Throughput Screen of Natural Compounds and Biomarkers for NSCLC Treatment by Differential Expression and Weighted Gene Coexpression Network Analysis (WGCNA) [PDF]

BioMed Research International
openalex   +1 more source

Combining WGCNA and machine learning to construct immune-related EMT patterns to predict HCC prognosis and immune microenvironment [PDF]

, 2023
Yating Sun, Shengfu He, Mingyang Tang, Ding Zhang, Meng Bao, Jiawen Yu, Yanyan Liu, Jiabin Li   +7 more
openalex   +1 more source

Genome and transcriptome‐based identification and expression profiling of chemosensory gene families across developmental stages and tissues in Sirex noctilio (Hymenoptera: Siricidae)

Insect Molecular Biology, EarlyView.
The first draft genome of Sirex noctilio was produced. Fifteen S. noctilio transcriptomes were sequenced to study chemosensory gene expression patterns. SnocOR16 and SnocSNMP1 displayed tissue‐ and sex‐specific expression patterns. Abstract The Sirex woodwasp (Sirex noctilio; Hymenoptera: Siricidae) is among the most destructive invasive pests ...
Alisa Postma, Leandri Klynsmith, Tuan A. Duong, Jeremy Dean Allison, Werner Smidt, Robert M. Waterhouse, Peter Lesny, Jan Philip Oeyen, Malte Petersen, Sebastian Martin, Shanlin Liu, Xin Zhou, Tanja Ziesmann, Alexander Donath, Christoph Mayer, Bernhard Misof, Oliver Niehuis, Ralph S. Peters, Lars Podsiadlowski, Martin P. A. Coetzee, Fourie Joubert, Bernard Slippers   +21 more
wiley   +1 more source