Results 31 to 40 of about 45,444 (316)

Co-expression modules construction by WGCNA and identify potential hub genes and regulation pathways of postpartum depression

Frontiers in Bioscience-Landmark, 2021
Purpose: The purpose of our present study was to, for the first time, identify key genes associated with postpartum depression (PPD) and discovery the potential molecular mechanisms of this condition.
Zhifang Deng, Wei Cai, Jue Liu, Aiping Deng, Yuan Yang, Jie Tu, Cheng Yuan, Han Xiao, Wenqi Gao   +8 more
doaj   +1 more source

WGCNA combined with GSVA to explore biomarkers of refractory neocortical epilepsy

IBRO Neuroscience Reports, 2022
About two-thirds of epilepsy patients relapse within five years after surgery. It is significant to note that the limitations of current treatments stem from a lack of understanding of molecular mechanisms. In this study, Weighted Gene Co-expression Network Analysis (WGCNA) and Gene set variation analysis (GSVA) methods were used to analyze the total ...
Rui Zhang, Yan Chen, Jia He, Hai-yan Gou, Yu-lan Zhu, Yan-mei Zhu   +5 more
openaire   +3 more sources

Identification of Immune-Related Key Genes in Ovarian Cancer Based on WGCNA [PDF]

Frontiers in Genetics, 2021
Background: Ovarian cancer (OV) is a fatal gynecologic malignancy and has poor survival rate in women over the age of forty. In our study, we aimed to identify genes related to immune microenvironment regulations and explore genes associated with OV prognosis.Methods: The RNA-seq data of GDC TCGA Ovarian Cancer cohort of 376 patients was retrieved from
Qingli Quan, Qingli Quan, Xinxin Xiong, Shanyun Wu, Meixing Yu   +4 more
openaire   +3 more sources

Identification of crucial genes in abdominal aortic aneurysm by WGCNA

PeerJ, 2019
Background Abdominal aortic aneurysm (AAA) is the full thickness dilation of the abdominal aorta. However, few effective medical therapies are available. Thus, elucidating the molecular mechanism of AAA pathogenesis and exploring the potential molecular target of medical therapies for AAA is of vital importance.
Siliang Chen, Dan Yang, Chuxiang Lei, Yuan Li, Xiaoning Sun, Mengyin Chen, Xiao Wu, Yuehong Zheng   +7 more
openaire   +3 more sources

Identification of an Immune-Related Gene Diagnostic Model and Potential Drugs in Sepsis Using Bioinformatics and Pharmacogenomics Approaches

Infection and Drug Resistance, 2023
Peng Chen,1 Juan Chen,2 Jinghe Ye,1 Limin Yang1 1Department of Urology, General Hospital of Northern Theater Command PLA, Shenyang, People’s Republic of China; 2Department of Oncology, General Hospital of Northern Theater Command PLA, Shenyang, People’s ...
Chen P, Chen J, Ye J, Yang L
doaj  

Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure [PDF]

, 2019
Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvest 1352 healthy and failing human hearts directly from transplant center operating rooms, and ...
Ashley, Euan A., Bernstein, Daniel, Brandimarto, Jeff, Cappola, Thomas, Chang, Alex C., Chin, Elizabeth T., Connolly, Andrew, Cordero, Pablo, Depaoli-Roach, Anna A., Dewey, Frederick, Erbilgin, Ayca, Glazer, Nicole, Gloudemans, Michael J., Hakonarson, Hakon, Hannenhalli, Sridhar, Huang, Yong, Li, Hongzhe, Li, Mingyao, Lusis, Aldons J., Malloy, Christine, Margulies, Kenneth B., Montgomery, Stephen B., Moravec, Christine S., Morley, Michael, Parikh, Victoria N., Pavlovic, Aleksandra, Ritter, Scott, Shang, Ching, Skreen, Jamie, Smith, Kevin S., Tang, W. H. Wilson, Waggott, Daryl, Wheeler, Matthew T., Zaleta, Kathia, Zhao, Mingming   +34 more
core   +2 more sources

Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines. [PDF]

, 2018
Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries.
Bunn, David A, Deist, Melissa S, Dekkers, Jack CM, Gallardo, Rodrigo A, Kaiser, Michael G, Kelly, Terra R, Lamont, Susan J, Zhang, Jibin, Zhou, Huaijun   +8 more
core   +3 more sources

WGCNA combined with machine learning to find potential biomarkers of liver cancer

Medicine, 2023
The incidence of hepatocellular carcinoma (HCC) has been increasing in recent years. With the development of various detection technologies, machine learning is an effective method to screen disease characteristic genes. In this study, weighted gene co-expression network analysis (WGCNA) and machine learning are combined to find potential biomarkers of
Lv, Jia-Hao, Hou, A-Jiao, Zhang, Shi-Hao, Dong, Jiao-Jiao, Kuang, Hai-Xue, Yang, Liu, Jiang, Hai   +6 more
openaire   +2 more sources

Identification of key immune cell-related genes involved in tumorigenesis and prognosis of cervical squamous cell carcinoma

Human Vaccines & Immunotherapeutics, 2023
The infiltration of immune cells can significantly affect the prognosis and immune therapy of patients with cervical squamous cell carcinoma (CSCC). This study aimed to explore key immune cell-related genes in the tumorigenesis and prognosis of CSCC. The
Chunxiao Yan, Yanyan Ma, Junyan Li, Xuejun Chen, Jiong Ma   +4 more
doaj   +1 more source

Diel transcriptional response of a California Current plankton microbiome to light, low iron, and enduring viral infection. [PDF]

, 2019
Phytoplankton and associated microbial communities provide organic carbon to oceanic food webs and drive ecosystem dynamics. However, capturing those dynamics is challenging. Here, an in situ, semi-Lagrangian, robotic sampler profiled pelagic microbes at
Allen, AE, Allen, EE, Allen, L Zeigler, Aylward, FO, Chavez, FP, Delong, EF, Fontanez, KM, Kolody, BC, McCrow, JP, Moniruzzaman, M, Moustafa, A, Scholin, CA, Worden, AZ   +12 more
core   +2 more sources