Results 31 to 40 of about 57,794 (383)

Positively Correlated miRNA-miRNA Regulatory Networks in Mouse Frontal Cortex During Early Stages of Alcohol Dependence [PDF]

, 2013
Although the study of gene regulation via the action of specific microRNAs (miRNAs) has experienced a boom in recent years, the analysis of genome-wide interaction networks among miRNAs and respective targeted mRNAs has lagged behind.
Blednov, Yuri A., Gorini, Giorgio, Harris, R. Adon, Mayfield, R. Dayne, Nunez, Yury O., Ponomareva, Olga N., Truitt, Jay M.   +6 more
core   +2 more sources

Identification of therapeutic targets and prognostic biomarkers in cholangiocarcinoma via WGCNA

Frontiers in Oncology, 2022
BackgroundCholangiocarcinoma (CCA) is a highly aggressive malignant tumor for which limited treatment methods and prognostic signatures are available. This study aims to identify potential therapeutic targets and prognostic biomarkers for CCA.MethodsBased on differentially expressed genes (DEGs) identified from The Cancer Genome Atlas (TCGA) data, our ...
Lei Xu, Ting Xiao, Ling Xu, Wei Yao
openaire   +3 more sources

Comparative transcriptomic and weighted gene co-expression network analysis to identify the core genes in the cultivars of Musa acuminata under both infected and chemical perturbated conditions

Plant Signaling & Behavior, 2023
Banana is a high nutrient crop, which ranks fourth in terms of gross value production. Fusarium wilt of banana, caused by Fusarium oxysporum f. sp. cubense tropical race 4 (FocTR4), is considered the most destructive disease leading to the complete loss ...
PTV Lakshmi, Amrendra Kumar, Ajna A. S., Abitha P Raveendran, Anjali Chaudhary, Adhitthan Shanmugam, Annamalai Arunachalam   +6 more
doaj   +1 more source

Co-expression modules construction by WGCNA and identify potential hub genes and regulation pathways of postpartum depression

Frontiers in Bioscience-Landmark, 2021
Purpose: The purpose of our present study was to, for the first time, identify key genes associated with postpartum depression (PPD) and discovery the potential molecular mechanisms of this condition.
Zhifang Deng, Wei Cai, Jue Liu, Aiping Deng, Yuan Yang, Jie Tu, Cheng Yuan, Han Xiao, Wenqi Gao   +8 more
doaj   +1 more source

Gene Co-expression Network and Copy Number Variation Analyses Identify Transcription Factors Associated With Multiple Myeloma Progression [PDF]

, 2019
Multiple myeloma (MM) has two clinical precursor stages of disease: monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). However, the mechanism of progression is not well understood.
Abu Zaid, Mohammad, Han, Zhi, Huang, Kun, Huang, Zhi, Johnson, Travis S., Xiang, Shunian, Yu, Christina Y., Zhan, Xiaohui   +7 more
core   +5 more sources

WGCNA combined with GSVA to explore biomarkers of refractory neocortical epilepsy

IBRO Neuroscience Reports, 2022
About two-thirds of epilepsy patients relapse within five years after surgery. It is significant to note that the limitations of current treatments stem from a lack of understanding of molecular mechanisms. In this study, Weighted Gene Co-expression Network Analysis (WGCNA) and Gene set variation analysis (GSVA) methods were used to analyze the total ...
Rui Zhang, Yan Chen, Jia He, Hai-yan Gou, Yu-lan Zhu, Yan-mei Zhu   +5 more
openaire   +3 more sources

Identifying Potential Diagnostic Genes for Diabetic Nephropathy Based on Hypoxia and Immune Status

Journal of Inflammation Research, 2021
Changyan Li,1 Feng Su,1 Le Zhang,2 Fang Liu,3 Wenxing Fan,1 Zhen Li,4 JingYuan Ma1 1Department of Nephrology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, People’s Republic of China; 2Institute for Integrative ...
Li C, Su F, Zhang L, Liu F, Fan W, Li Z, Ma J   +6 more
doaj  

Global isoform-specific transcript alterations and deregulated networks in clear cell renal cell carcinoma. [PDF]

, 2018
Extensive genome-wide analyses of deregulated gene expression have now been performed for many types of cancer. However, most studies have focused on deregulation at the gene-level, which may overlook the alterations of specific transcripts for a given ...
Girke, Thomas, Hamilton, Michael J, Martinez, Ernest   +2 more
core   +1 more source

Integrative Analysis From Multicenter Studies Identifies a WGCNA-Derived Cancer-Associated Fibroblast Signature for Ovarian Cancer

Frontiers in Immunology, 2022
Cancer-associated fibroblasts (CAFs) are a major contributor to tumor stromal crosstalk in the tumor microenvironment (TME) and boost tumor progression by promoting angiogenesis and lymphangiogenesis.
Songwei Feng, Yi Xu, Zhu Dai, Han Yin, Kecheng Zhang, Yang Shen   +5 more
semanticscholar   +1 more source

Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines. [PDF]

, 2018
Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries.
Bunn, David A, Deist, Melissa S, Dekkers, Jack CM, Gallardo, Rodrigo A, Kaiser, Michael G, Kelly, Terra R, Lamont, Susan J, Zhang, Jibin, Zhou, Huaijun   +8 more
core   +3 more sources