Results 61 to 70 of about 45,444 (316)
Advanced Science, EarlyView.This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun +17 more
wiley +1 more source
Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin. [PDF]
, 2017 Human skin consists of multiple cell types, including epithelial, immune, and stromal cells. Transcriptomic analyses have previously been performed from bulk skin samples or from epithelial and immune cells expanded in cell culture.
Ahn, Richard S +9 more
core +1 more source
Identification of Important Modules and Biomarkers in Breast Cancer Based on WGCNA.
OncoTargets and therapy, 2020 Breast cancer (BRCA) has the highest incidence among female malignancies, and the prognosis for these patients remains poor.In this study, core modules and central genes related to BRCA were identified through a weighted gene co-expression network analysis (WGCNA).
Tian,Zelin +6 more
openaire +3 more sources
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
Adipocyte, 2020 T2D is a complex disease with poorly understood mechanisms. In Asian Indians, it is associated with “thin fat” phenotype which resembles with partial lipodystrophy. We hypothesized that disturbed expression of lipodystrophy genes might play a role in T2D
Aditya Saxena +4 more
doaj +1 more source
Identification Of key prognostic genes in ovarian cancer using WGCNA and LASSO analysis
All Life, 2022 Ovarian cancer (OC) is the fifth leading cause of death in females. This study aims to identify new prognostic genes of OC through bioinformatics analysis. Based on two datasets from the NCBI GEO public database, we constructed two WGCNA networks.
Zhong Yu, Ling Ouyang
doaj +1 more source
Modeling the functional genomics of autism using human neurons. [PDF]
, 2012 Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation,
Chen, L +10 more
core +1 more source
Advanced Science, EarlyView.This study finds that the interaction between ABA‐OsCIPK2‐OsSWEET1A reduces the allocation of methane producing bacteria carbon source (acetic acid) content to the rhizosphere soil of ratoon season rice, thereby reducing methane emissions. Abstract Rice paddies are a major, persistent source of atmospheric methane (CH4), emission rates depend on the ...
Jingnan Zou +14 more
wiley +1 more source
International Journal of General Medicine, 2021 Zhiqiang Shi,1 Xinghui Li,2 Long Zhang,1 Yilang Luo,1 Bikal Shrestha,3 Xuegang Hu1 1Department of Stomatology, University of Chinese Academy of Sciences - Shenzhen Hospital, Shenzhen, Guangdong, 518107, People’s Republic of China; 2Department of ...
Shi Z +5 more
doaj
Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes. [PDF]
, 2018 Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes.
A Battle +82 more
core +1 more source