Results 81 to 90 of about 45,444 (316)

Unveiling microbial succession dynamics on different plastic surfaces using WGCNA

PLOS ONE
Over recent decades, marine microorganisms have increasingly adapted to plastic debris, forming distinct plastic-attached microbial communities. Despite this, the colonization and succession processes on plastic surfaces in marine environments remain poorly understood. To address this knowledge gap, we conducted a microbiome succession experiment using
Keren Davidov, Sheli Itzahri, Liat Anabel Sinberger, Matan Oren   +3 more
openaire   +3 more sources

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

Profiling the accumulation of ten bioactive compounds in Rheum officinale across different growth years using integrated HPLC and transcriptomic approaches

Medicinal Plant Biology
Rheum officinale is a prominent traditional medicinal herb in the Chinese Pharmacopeia. Variations in the composition and accumulation of secondary metabolites in R. officinale have been observed to correlate with harvest periods. This study investigated
Yi-min Li, Xue-ru Wang, Ge Yang, Ting-ting Yan, Xiao-chen Hu, Liang Peng, Jing Gao, Feng Yan, Gang Zhang   +8 more
doaj   +1 more source

Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. [PDF]

, 2016
BackgroundOur previous studies showed that the non-psychoactive cannabinoid, cannabidiol (CBD), ameliorates the clinical symptoms in mouse myelin oligodendrocyte glycoprotein (MOG)35-55-induced experimental autoimmune encephalomyelitis model of multiple ...
Coppola, Giovanni, Gao, Fuying, Juknat, Ana, Kaushansky, Nathali, Kozela, Ewa, Vogel, Zvi   +5 more
core   +2 more sources

Identification of Mannose‐Capped‐Arabinomannan 101‐mer as a Potential Influenza Virus Vaccine Adjuvant

Advanced Science, EarlyView.
Well‐defined and synthetic mannose‐capped arabinomannan 101‐mer from Mycobacterium tuberculosis cell wall was identified as a potent influenza vaccine adjuvant, boosting the antibody response, realizing full protection and showing excellent safety. ABSTRACT Many natural bacterial components as adjuvants can activate the host immune system, but the ...
Yu‐Fang Zhang, Ruihong Xu, Jia Luo, Yuxin Ma, Guozhi Xiao, Ye Liu   +5 more
wiley   +1 more source

Gene Network Analysis of Hepatocellular Carcinoma Identifies Modules Associated with Disease Progression, Survival, and Chemo Drug Resistance

International Journal of General Medicine, 2021
Hua Ye,1 Mengxia Sun,2 Shiliang Huang,1 Feng Xu,1 Jian Wang,3 Huiwei Liu,1 Liangshun Zhang,1 Wenjing Luo,1 Wenying Guo,1 Zhe Wu,1 Jie Zhu,4 Hong Li4 1Department of Gastroenterology, Ningbo Medical Treatment Center Lihuili Hospital, Medical School of ...
Ye H, Sun M, Huang S, Xu F, Wang J, Liu H, Zhang L, Luo W, Guo W, Wu Z, Zhu J, Li H   +11 more
doaj  

Co-Expression Network Analysis Identifies Possible Hub Genes in Aging of the Human Prefrontal Cortex

Revista Ciencias de la Salud, 2019
Introduction: Aging is the main risk factor for the development of chronic diseases such as cancer, diabetes, Parkinson’s disease, and Alzheimer’s disease.
César Payán-Gómez, MD, MSc, PhD, Julián Riaño-Moreno, MD, MSc, Diana Amador-Muñoz, MD, MSc, Sandra Ramírez-Clavijo, MSc, PhD   +3 more
doaj   +1 more source

Network and biosignature analysis for the integration of transcriptomic and metabolomic data to characterize leaf senescence process in sunflower [PDF]

, 2016
In recent years, high throughput technologies have led to an increase of datasets from omics disciplines allowing the understanding of the complex regulatory networks associated with biological processes.
Di Rienzo, Julio Alejandro, Fernández, Paula del Carmen, Heinz, Ruth Amelia, Higgins, Janet, Moschen, Sebastián Nicolás, Paniego, Norma Beatriz   +5 more
core   +5 more sources

K-Module Algorithm: An Additional Step to Improve the Clustering Results of WGCNA Co-Expression Networks [PDF]

, 2021
Jie Hou, Xiufen Ye, Chuanlong Li, Yixing Wang   +3 more
openalex   +1 more source