Results 81 to 90 of about 37,320 (316)

Development of Age‐ and Sex‐Specific Metabolomics‐Based Biological Ageing Clocks for 10‐Year Mortality Prediction

Advanced Science, EarlyView.
Metabolomics‐based ageing clocks developed using blood biomarkers from over 215 000 European adults, improved the prediction of 10‐year all‐cause mortality compared to traditional models. Biological age acceleration is associated with higher mortality risk, as each additional year of metabolic age corresponded to at least 8% increased risk. These tools
Lei Peng, Ruijie Xie, Bernd Holleczek, Hermann Brenner, Ben Schöttker   +4 more
wiley   +1 more source

Identification and Verification of the Oxidative Stress-Related Signature Markers for Intracranial Aneurysm-Applied Bioinformatics

Frontiers in Bioscience-Landmark
Background: Intracranial aneurysm (IA) is a localized abnormal dilation of the cerebral vascular wall, the degeneration of which is closely related to high oxidative stress.
Jiayun Zhang, Pengxin Duan, Bo Nie, Zhe Zhang, Rui Shi, Qiming Liu, Shiduo Wang, Tiantian Xu, Junbiao Tian   +8 more
doaj   +1 more source

A Modified Soft-thresholding Approach in the Transcriptomic Analysis of Adaptation of E.coli to Alternating Substrate Conditions

Hittite Journal of Science and Engineering, 2019
The expression of genes that are functionally related is considered to change together in response to deterioration of internal or external order. The system-level analysis of these changes has become widespread in recent years.
Muhammed Erkan Karabekmez
doaj   +1 more source

Population-Specific gene expression profiles in prostate cancer: insights from Weighted Gene Co-expression Network Analysis (WGCNA)

World Journal of Surgical Oncology
This study investigates the genetic factors contributing to the disparity in prostate cancer incidence and progression among African American men (AAM) compared to European American men (EAM). The research focuses on employing Weighted Gene Co-expression
Laleh Manouchehri, Z. Zinati, Leyla Nazari   +2 more
semanticscholar   +1 more source

Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming

Advanced Science, EarlyView.
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu, Weiguang Wang, Jian Zhang, Lei Liu, Minpeng Huang, Lei Diao, Shuang Feng, Qiong Yang, Hao Qiu, Bing Pan, Renee A Reijo Pera, Ji Liu, Ninuo Xia, Fang Fang   +13 more
wiley   +1 more source

Identification of Hub Genes Associated with COPD Through Integrated Bioinformatics Analysis

International Journal of COPD, 2022
Lin Chen,1,2 Donglan Zhu,1 Jinfu Huang,1 Hui Zhang,1 Guang Zhou,1 Xiaoning Zhong1 1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China ...
Chen L, Zhu D, Huang J, Zhang H, Zhou G, Zhong X   +5 more
doaj  

Identification of biomarkers associated with ferroptosis in diabetic retinopathy based on WGCNA and machine learning

Frontiers in Genetics
Objective: Diabetic retinopathy (DR) is a chronic progressive eye disease that affects millions of diabetic patients worldwide, and ferroptosis may contribute to the underlying mechanisms of DR.
Hui-qing Guo, Rong Xue, Guangming Wan
semanticscholar   +1 more source

FXYD3 Promotes Tumor Progression by Binding With IRF7 to Regulate JAK2/STAT5 Signaling in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
FXYD3 binds IRF7 via its 60–87aa domain, triggering a cGAS/STING‐mediated positive feedback loop amplified by type I interferon. This sustains JAK2/STAT5 activation, accelerating ICC progression. Targeting FXYD3 with siFXYD3@PEP suppresses tumors and enhances chemotherapy sensitivity. Abstract Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis,
Yan Zhou, Xiaofeng Shen, Shuo Zhang, XiaoHong Pu, Zipeng Xu, Xiang Zhao, Wei Feng, Yuan Liang, Xingtao He, Aihua Yang, Yudong Qiu, Yihang Yuan, Chaobo Chen, Jun Chen   +13 more
wiley   +1 more source

Super-Enhancer-Associated Hub Genes In Chronic Myeloid Leukemia Identified Using Weighted Gene Co-Expression Network Analysis

Cancer Management and Research, 2019
Hongying Ma,1,2 Jian Qu,3 Jian Luo,1,2 Tingting Qi,3 Huanmiao Tan,4 Zhaohui Jiang,1 Haiwen Zhang,1 Qiang Qu1,2 1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People’s Republic of China; 2Institute for ...
Ma H, Qu J, Luo J, Qi T, Tan H, Jiang Z, Zhang H, Qu Q   +7 more
doaj  

Decreased PTGDS Expression Predicting Poor Survival of Endometrial Cancer by Integrating Weighted Gene Co-Expression Network Analysis and Immunohistochemical Validation

Cancer Management and Research, 2020
Ruoyao Zou,1,2 Mingjun Zheng,3 Mingzi Tan,4 Haoya Xu,1,2 Nannan Luan,1 Liancheng Zhu1,2 1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, People’s Republic of China; 2Key Laboratory
Zou R, Zheng M, Tan M, Xu H, Luan N, Zhu L   +5 more
doaj