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White adipose tissue and cardiovascular disease
Best Practice & Research Clinical Endocrinology & Metabolism, 2005Adipocytes have recently been shown to secrete a variety of bioactive substances called 'adipocytokines', and have been recognized as endocrine cells. Tumour necrosis factor (TNF)-alphaalpha, plasminogen activator inhibitor-1 (PAI-1) and heparin-binding epidermal-growth-factor-like growth factor (HBEGF) are among these adipocytokines, and they ...
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Explant Cultures of White Adipose Tissue
2008Obesity is characterized by increased adiposity of visceral and subcutaneous depots as well as other organs, including the vasculature. These fat depots secrete various hormone-like proteins implicated in metabolic homeostasis (e.g., adiponectin, resistin), the central control of appetite (e.g., leptin) and the increased production of cytokines.
Thalmann S, Juge-Aubry CE, Meier CA
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Sandwiched White Adipose Tissue: A Microphysiological System of Primary Human Adipose Tissue
Tissue Engineering Part C: Methods, 2018White adipose tissue (WAT) is a critical organ in both health and disease. However, physiologically faithful tissue culture models of primary human WAT remain limited, at best. In this study we describe a novel WAT culture system in which primary human WAT is sandwiched between tissue-engineered sheets of adipose-derived stromal cells.
Frank H, Lau +12 more
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The American Journal of Pathology
Adipose tissue plays a crucial role in energy storage, but it also acts as an endocrine organ by secreting hormones and proinflammatory molecules. It regulates various processes, including adipogenesis, metabolism, and inflammation. White and brown adipose tissue (WAT and BAT) consists of white and brown adipocytes, respectively, which differ in ...
Thales M.H. Dourado, Carlos R. Tirapelli
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Adipose tissue plays a crucial role in energy storage, but it also acts as an endocrine organ by secreting hormones and proinflammatory molecules. It regulates various processes, including adipogenesis, metabolism, and inflammation. White and brown adipose tissue (WAT and BAT) consists of white and brown adipocytes, respectively, which differ in ...
Thales M.H. Dourado, Carlos R. Tirapelli
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Autophagy in White Adipose Tissue
2014Autophagy is a mechanism for intracellular degradation of cytoplasmic components including macromolecules and organelles. It has been shown to be involved in a large number of physiological and pathological processes. Studies have recently uncovered an important role of autophagy in the process of adipogenesis.
Scott G. Goldman +2 more
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In Vitro Culture of White Adipose Tissue
White adipose tissue (WAT) plays a crucial endocrine organ that regulates blood glucose and lipid levels, satiety, and inflammation. Before the described technique, primary white adipocytes could not be stably cultured in vitro. The lack of a reliable primary culture model impeded research in WAT metabolism and drug development.Jake J, Fontenot, Frank H, Lau
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Regression of white adipose tissue in diabetic rats
American Journal of Physiology-Endocrinology and Metabolism, 1989The effects of long-term diabetes (4 wk) on the development of parametrial (PWAT) and retroperitoneal (RWAT) white adipose tissues were studied in young Sprague-Dawley rats (170-200 g) injected with a single dose of streptozotocin (75 mg/kg). Diabetes stopped animal growth and totally abolished the normal increases in the wet weight, total protein ...
A, Géloën, P E, Roy, L J, Bukowiecki
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Metabolism of White Adipose Tissue
2007Triacylglycerols (TAGs) stored in adipose tissue are by far the largest site of energy storage. Adipocytes continuously synthesize and break down these TAGs depending on the body energy status and its hormonal environment. They act as a “buffer” for plasma lipids and also for lipids stored in other tissues.
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Methods for Performing Lipidomics in White Adipose Tissue
2014Lipid metabolism is central to the function of white adipose tissue, with the tissue having a central role in storing triacylglycerides following feeding and releasing free fatty acids and monoacylglycerides during periods of fasting. In addition, lipid species have been suggested to play a role in lipotoxicity and as signaling molecules during adipose
Lee D, Roberts +3 more
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