Results 31 to 40 of about 499,911 (300)
The Emerging Importance of Mitochondria in White Adipocytes: Neither Last nor Least [PDF]
Endocrinology and Metabolism, 2023 The growing recognition of mitochondria’s crucial role in the regulation of white adipose tissue remodeling and energy balance underscores its significance. The marked metabolic diversity of mitochondria provides the molecular and cellular foundation for
Juan Cai, Fenfen Wang, Mengle Shao
doaj +1 more source
AdipoAtlas: Mapping out human white adipose tissue [PDF]
Cell Reports Medicine, 2021 In this issue of Cell Reports Medicine, Lange and colleagues1 significantly improve lipid identification accuracy, detection, and quantification to provide AdipoAtlas, an in-depth lipidomic profile of human white adipose tissue (WAT). Importantly, they define obesity-mediated lipid alterations, which may provide insight into the etiology of associated ...
Abhijit B. Shinde, Elma Zaganjor
openaire +3 more sources
Differential Tissue Response to Growth Hormone in Mice [PDF]
, 2018 Growth hormone (GH) has been shown to act directly on multiple tissues throughout the body. Historically, it was believed that GH acted directly in the liver and only indirectly in other tissues via insulin‐like growth hormone 1 (IGF‐1).
Banerjee, Ronadip R. +4 more
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Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning
International Journal of Molecular Sciences, 2022 The present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. In rodents, when exposed to decreasing temperatures, females activate thermogenesis earlier. Results obtained in humans
Iker Gómez-García +4 more
openaire +5 more sources
miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit [PDF]
, 2013 Brown adipocytes are a primary site of energy expenditure and reside not only in classical brown adipose tissue but can also be found in white adipose tissue.
Chen, Y. +6 more
core +1 more source
FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue
Molecular Metabolism, 2017 Objective: Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates metabolic homeostasis. Previous work has suggested that impairment of FGF21 signaling in adipose tissue may occur through downregulation of the obligate FGF21 co ...
Kathleen R. Markan +5 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2020 Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date several types of adipose tissue have been identified, namely white, brown, and beige, that reside in various specific anatomical locations throughout the body. The
Alan Chait, Laura J. den Hartigh
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PexRAP inhibits PRDM16-mediated thermogenic gene expression [PDF]
, 2017 How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear.
Dean, John M +8 more
core +3 more sources
Mitochondrial dysfunction in white adipose tissue [PDF]
Trends in Endocrinology & Metabolism, 2012 Although mitochondria in brown adipose tissue and their role in non-shivering thermogenesis have been widely studied, we have only a limited understanding of the relevance of mitochondria in white adipose tissue (WAT) for cellular homeostasis of the adipocyte and their impact upon systemic energy homeostasis.
Christine M, Kusminski +1 more
openaire +2 more sources
Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming [PDF]
, 2017 BACKGROUND: The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology and in
Czech, Michael P +11 more
core +7 more sources