Results 131 to 140 of about 4,320,312 (250)

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Plant Secondary Compounds Promote White Adipose Tissue Browning via Modulation of the Gut Microbiota in Small Mammals. [PDF]

Int J Mol Sci, 2023
Ren S, Zhang L, Tang X, Fan C, Zhao Y, Cheng Q, Zhang Y.   +6 more
europepmc   +1 more source

The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons

, 2018
Obesity is a public health issue that affects more than 600 million adults worldwide. The disease is characterized by fat accumulation, mainly in the abdominal area.
Rodrigo F. de Moura, Rodrigo M. Pereira, Kellen C. da Cruz Rodrigues, Adelino S. R. da Silva, Thaís D. P. de Campos, Dennys E. Cintra, Eduardo R. Ropelle, José R. Pauli, Michel B. de Araújo, Leandro P. de Moura   +9 more
core   +1 more source

Inhibition of the NR4A1‐mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity.
Wanning Qiao, Cun Ku, G. V. Naveen Kumar, Jonathan D. Brown, Manni Wu, Chenhang Li, Jiyu Xie, Huicui Meng, Litao Sun, Tao Zhou, Dong Liang, Yiwei Li, Matthew L. Steinhauser, Yang Zhang   +13 more
wiley   +1 more source

Angiotensin type 2 receptor activation promotes browning of white adipose tissue and brown adipogenesis

, 2017
Brown adipose tissue dissipates energy in the form of heat. Recent studies have shown that adult humans possess both classical brown and beige adipocytes (brown-like adipocytes in white adipose tissue, WAT), and stimulating brown and beige adipocyte ...
Leow, Melvin Khee-Shing, Aung Than, Shaohai Xu, Xu, Shaohai, Ru Li, Lei Sun, Chen, Peng, Li, Ru, Sun, Lei, MelvinKhee-Shing Leow, Peng Chen, Than, Aung   +11 more
core   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Hepcidin deficiency in mice impairs white adipose tissue browning possibly due to a defect in de novo adipogenesis. [PDF]

Sci Rep, 2023
Deschemin JC, Ransy C, Bouillaud F, Chung S, Galy B, Peyssonnaux C, Vaulont S.   +6 more
europepmc   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Electroacupuncture activates PKA / CREB signaling pathway to promote browning of white fat in obese rats

针刺研究
ObjectiveTo observe the effect of electroacupuncture （EA） on lipid metabolism and cyclic adenosine monophosphate-dependent protein kinase A （PKA）/cyclic adenosine monophosphate-responsive element binding protein （CREB） signalling pathway in obese rats ...
LIAO Cai, TANG Cheng-lin, QIU Wei, YANG Yan, YANG Yun-hao, LIU He-jing, WANG Jia-pei, DENG Jun-yuan   +7 more
doaj   +2 more sources

Angiotensin II Promotes White Adipose Tissue Browning and Lipolysis in Mice. [PDF]

Oxid Med Cell Longev, 2022
Cai Z, Fang L, Jiang Y, Liang M, Wang J, Shen Y, Wang Z, Liang F, Huo H, Pan C, Shen L, He B.   +11 more
europepmc   +1 more source