Results 111 to 120 of about 4,320,312 (250)

Mogroside V Promotes Brown Adipose Thermogenesis via FTO‐m6A‐LETMD1‐UCP1 Pathway to Combat Obesity

Phytotherapy Research, EarlyView.
Mogroside V (MV) alleviates high‐fat diet‐induced obesity and metabolic dysfunction. Mechanistically, MV suppresses FTO expression, thereby increasing m6A modification of Letmd1 mRNA and enhancing its YTHDC2‐dependent stabilization. Theincreased LETMD1 expression is associated with elevated PGC1α and UCP1 levels, contributing to brown adipocyte ...
Yuan‐hai Sun, Ling‐huan Li, Ya‐qian Feng, Teng‐jiao Zhao, Min‐you Qi, Han‐bing Li   +5 more
wiley   +1 more source

Microplastics and the Endocrine–Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid–Adipose Axis

Environmental Toxicology, EarlyView.
ABSTRACT Microplastics (MPs) have been identified as major environmental contaminants that can affect organisms directly and act as carriers of particles and chemical additives, thereby aggravating endocrine networks that coordinate metabolic homeostasis.
Sunday Amos Onikanni, Babasola Aiyeku, Marjorie Dardis Murucci, Temitope Aribigbola, Kenia Bispo, Oluwatosin Stella Olayinka, Rômulo Sperduto Dezonne, Sara Gemini Piperni, Paula Soares, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Anthocyanins and the browning of white adipose tissue: role of mitochondria and mechanisms of action

Redox Experimental Medicine
Obesity is defined as a chronic disease characterized by fat accumulation excess. Obesity and consumption of high-fat diets are associated with alteration in mitochondrial function and biogenesis.
Eleonora Cremonini
doaj   +1 more source

Adipose Angiogenesis Models in Animals and Methodology

, 2013
Adipose tissue angiogenesis plays a crucial role in the organism as blood vessels are required to supply nutrients and oxygen to the adipose tissue and to remove metabolic waste products.
Honek, J, Lim, S, Sharon Lim, Yihai Cao, Cao, Y, Jennifer Honek   +5 more
core   +1 more source

Gut Microbiota of Gray Snub‐Nosed Monkeys: Adaptation to Seasonal Variations Through Energy Compensation and Thermogenesis

Integrative Zoology, EarlyView.
Based on metagenome‐assembled genomes (MAGs), the gut microbiota of the gray snub‐nosed monkeys recovered 1229 non‐redundant MAGs. The gut microbiota showed an enhanced capacity to produce energy substrates with increased conversion activity of these substrates during winter.
Yue Sun, Mingyi Zhang, Xiaochen Wang, Xiaolong Huang, Yanze Yu, Huijuan Pan, Haibo Li, Lei Shi, Wei Yang, Chen Zhang, Bo Ding, Xun Liu, Jianfeng Li, Changjiang Qian, Boxing Cheng, Chao Zhang, Jingcheng Ran, Ming Li   +17 more
wiley   +1 more source

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science
Fine particulate matter (PM2.5) contributes to metabolic dysfunction, but its effects on adipose tissue browning remain unclear. Here, we showed that PM2.5 exposure inhibited inguinal white adipose tissue (iWAT) browning by downregulating protein ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
doaj   +1 more source

Physiological regulation and metabolic role of browning in white adipose tissue

, 2017
Great progress has been made in our understanding of the browning process in white adipose tissue (WAT) in rodents. The recognition that i) adult humans have physiologically inducible brown adipose tissue (BAT) that may facilitate resistance to obesity ...
Korać, Bato, Bato Korac, Stančić, Ana, Korać, Aleksandra, Ana Stancic, Biljana Buzadzic, Janković, Aleksandra, Vesna Otasevic, Aleksandra Korac, Otašević, Vesna, Buzadžić, Biljana, Aleksandra Jankovic   +11 more
core   +1 more source

More Than a Birthmark? A Growing Pediatric Skin Lesion

JEADV Clinical Practice, EarlyView.
Shatha Ahmad Al Hajjaj, Sara Al Janahi, Shaden Abdelhadi   +2 more
wiley   +1 more source

Unity Brings Mutual Benefits: The Huddling Strategies of Temperate‐Living Primates in Cold Environments

Integrative Zoology, EarlyView.
Cold exposure triggers enhanced huddling responses in golden snub‐nosed monkeys, characterized by increased huddling frequency, duration, and larger group formation. Huddling effectively improves thermal regulation by elevating body surface temperature and reducing heat loss, with individuals inside aggregations achieving greater thermal benefits than ...
Yongbo Li, Yang Yang, Zeyu Li, Jiao Yang, Hanzheng Yao, Yu Huan, Boyi Zhang, Junjie Mu, Xi Yang, Colin A. Chapman, Marcel Holyoak, Baoguo Li, Rong Hou   +12 more
wiley   +1 more source