Results 21 to 30 of about 24,272 (299)

Automatic segmentation of white matter hyperintensities and correlation analysis for cerebral small vessel disease

Frontiers in Neurology, 2023
ObjectiveCerebral white matter hyperintensity can lead to cerebral small vessel disease, MRI images in the brain are used to assess the degree of pathological changes in white matter regions.
Bin Xu, Bin Xu, Xiaofeng Zhang, Congyu Tian, Wei Yan, Yuanqing Wang, Doudou Zhang, Doudou Zhang, Xiangyun Liao, Xiaodong Cai, Xiaodong Cai   +10 more
doaj   +1 more source

Brain White Matter Structure and Amyloid Deposition in Black and White Older Adults: The ARIC‐PET Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background White matter abnormalities are a common feature of aging and Alzheimer disease, and tend to be more severe among Black individuals. However, the extent to which white matter abnormalities relate to amyloid deposition, a marker of Alzheimer ...
Keenan A. Walker, Noah Silverstein, Yun Zhou, Timothy M. Hughes, Clifford R. Jack, David S. Knopman, A. Richey Sharrett, Dean F. Wong, Thomas H. Mosley, Rebecca F. Gottesman   +9 more
doaj   +1 more source

MTI of white matter hyperintensities [PDF]

Brain, 2005
The severity of tissue changes associated with incidental white matter hyperintensities (WMH) in the elderly cannot be sufficiently determined by conventional MRI. We, therefore, performed a regional analysis of the magnetization transfer ratio (MTR) maps obtained on a 1.5 T scanner from 198 neurologically asymptomatic participants of the Austrian ...
Franz, Fazekas, Stefan, Ropele, Christian, Enzinger, Faton, Gorani, Alexandra, Seewann, Katja, Petrovic, Reinhold, Schmidt   +6 more
openaire   +2 more sources

Neuroticism and white matter hyperintensities

Journal of Psychiatric Research, 2023
Neuroticism is a major risk factor for neurodegenerative disorders, such as Alzheimer's disease and related dementias. This study investigates whether neuroticism is associated with white matter hyperintensities and whether this measure of brain integrity is a mediator between neuroticism and cognitive function. Middle-aged and older adults from the UK
Antonio Terracciano, Bertin Cenatus, Xianghe Zhu, Selin Karakose, Yannick Stephan, Sofia Marcolini, Peter P. De Deyn, Martina Luchetti, Angelina R. Sutin   +8 more
openaire   +4 more sources

APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia

Alzheimer’s Research & Therapy, 2023
Background White matter hyperintensities, a neuroimaging marker of small-vessel cerebrovascular disease and apolipoprotein ε4 (APOE4) allele, are important dementia risk factors.
Ashwati Vipin, Dilip Kumar, See Ann Soo, Fatin Zahra Zailan, Yi Jin Leow, Chen Ling Koh, Adeline Su Lyn Ng, Kok Pin Ng, Nagaendran Kandiah   +8 more
doaj   +1 more source

Histologic Definition of Enhancing Core and FLAIR Hyperintensity Region of Glioblastoma, IDH-Wild Type: A Clinico-Pathologic Study on a Single-Institution Series

Brain Sciences, 2023
The extent of resection beyond the enhancing core (EC) in glioblastoma IDH-wild type (GBM, IDHwt) is one of the most debated topics in neuro-oncology. Indeed, it has been demonstrated that local disease recurrence often arises in peritumoral areas and ...
Giuseppe Broggi, Roberto Altieri, Valeria Barresi, Francesco Certo, Giuseppe Maria Vincenzo Barbagallo, Magda Zanelli, Andrea Palicelli, Gaetano Magro, Rosario Caltabiano   +8 more
doaj   +1 more source

Increase of blood-brain barrier leakage is related to cognitive decline in vascular mild cognitive impairment

BMC Neurology, 2021
Background Blood-brain barrier (BBB) breakdown, as an early biomarker for vascular mild cognitive impairment (vMCI), has only been validated by a few studies.
Man Li, Yue Li, Long Zuo, Wenli Hu, Tao Jiang   +4 more
doaj   +1 more source

New insights in addressing cerebral small vessel disease: Associated with extracellular fluid in white matter

Frontiers in Neuroscience, 2022
ObjectiveTo explore the role of extracellular fluid, assessed by diffusion tensor imaging (DTI) metrics of free water (FW), in the white matter of patients with cerebral small vessel disease (CSVD).Materials and methodsThe baseline clinical and imaging ...
Haiyuan Lan, Xinjun Lei, Zhihua Xu, Songkuan Chen, Wanfeng Gong, Yunqi Cai   +5 more
doaj   +1 more source

Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study)

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Apart from nondippers’ impact on cardiovascular events, the prevalence of isolated nocturnal hypertension (INH) and its consequences on both the heart and brain were not clearly investigated in the general population.
Seong Hwan Kim, Chol Shin, Sunwon Kim, Jin‐Seok Kim, Sang Yup Lim, Hyeong‐Seok Seo, Hong Euy Lim, Ki‐Chul Sung, Goo‐Yeong Cho, Seung Ku Lee, Yong‐Hyun Kim   +10 more
doaj   +1 more source

White matter hyperintensities and hypobaric exposure [PDF]

Annals of Neurology, 2014
ObjectiveDemonstrate that occupational exposure to nonhypoxic hypobaria is associated with subcortical white matter hyperintensities (WMHs) on fluid‐attenuated inversion recovery magnetic resonance imaging (MRI).MethodsEighty‐three altitude chamber personnel (PHY), 105 U‐2 pilots (U2P), and 148 age‐ controlled and health‐matched doctorate degree ...
Stephen A, McGuire, Paul M, Sherman, S Andrea, Wijtenburg, Laura M, Rowland, Patrick M, Grogan, John H, Sladky, Andrew Y, Robinson, Peter V, Kochunov   +7 more
openaire   +2 more sources