Results 21 to 30 of about 114,628,411 (160)

Inhibition of Monosodium Urate Crystal-Induced Inflammation by Withaferin A

Journal of Pharmacy & Pharmaceutical Sciences, 2009
Purpose. Gouty arthritis is a characteristically intense acute inflammatory reaction resulting from the formation of sodium urate crystals in the joint cavity.
Mahaboobkhan Rasool, Sonal Chandal, Evan Prince Sabina   +2 more
doaj   +2 more sources

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal [PDF]

Pharmaceuticals, 2023
Cancer represents the second most deadly disease and one of the most important public health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy are the major types of treatment strategies that have been implemented in cancer
Suneel Kumar, Stephen O. Mathew, Ravindra Prasad Aharwal, Hardeep Singh Tulli, Chakrabhavi Dhananjaya Mohan, Gautam Sethi, Kwang-Seok Ahn, Kassidy Webber, Sardul Singh Sandhu, Anupam Bishayee   +9 more
doaj   +2 more sources

In Silico Identification of Plant-Derived GPX4 Inhibitors as Potential Ferroptosis Inducers: Molecular Docking, Dynamics, and ADMET Studies. [PDF]

Curr Issues Mol Biol
This study aims identify plant-derived compounds that can inhibit glutathione peroxidase 4 (GPX4) enzyme and evaluate them through molecular docking, dynamics simulations, and ADMET analyses.
Antmen ŞE, Öz H, Yalaza C, Canacankatan N.   +3 more
europepmc   +2 more sources

Overview of Ayurveda and Ashwagandha: Bioactive Phytochemicals and Potential Applications to Gliomas. [PDF]

Molecules
Ayurveda is the traditional medical system of India and has been in use for more than 5000 years. The focus of Ayurveda is to maintain harmony and balance of the three Doshas (Vata, Pitta, Kapha), or life forces, that govern the physiology and health of ...
Newton HB.
europepmc   +2 more sources

Network pharmacology and in-silico studies for molecular mechanisms of analgesic, anti-inflammatory and anti-arthritic effects of Withania somnifera (L.) Dunal phytoconstituents. [PDF]

J Ayurveda Integr Med
Background: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is an Ayurvedic herb belonging to the family Solanaceae. Objectives: This study aims to explore the analgesic, anti-inflammatory and anti-arthritic potential of phytoconstituents ...
Tambe MS, Shinde SR, Baheti AM, Nagar S, Pawar AT.   +4 more
europepmc   +2 more sources

Randomized, Double-Blind, Crossover Study Comparing the Bioavailability of 4 Ashwagandha (<i>Withania somnifera</i> (L.) Dunal) Extracts in Healthy Adults Under Fasting Condition. [PDF]

Curr Ther Res Clin Exp
Background: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is a well-known plant in ayurvedic medicine, widely valued for its therapeutic potential. Although numerous clinical studies have explored its diverse health benefits, limited data
Rathi P, Kim SK.
europepmc   +2 more sources

Computational discovery of natural inhibitors targeting enterovirus D68 3C protease using molecular docking pharmacokinetics and dynamics simulations. [PDF]

Sci Rep
Enterovirus D68 (EV-D68) is a significant global health threat, responsible for severe respiratory and neurological complications, with no FDA-approved antiviral treatments currently available.
Alsahag M.
europepmc   +2 more sources

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications. [PDF]

Phytother Res
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Yukta R, Gupta S, Kaur G, Mondal PS, Das M, Ranade A, Srivastava AK, Kumar S, Barthwal MK, Dikshit M.   +9 more
europepmc   +2 more sources

Discovery of eukaryotic cellular receptor for Withaferin A, a multifaceted drug from Withania somnifera plant

Medicine in Drug Discovery, 2022
Withaferin A is a dietary natural compound from a very popular Ayurvedic plant called Ashwagandha (Withania Somnifera). Since the discovery of Withaferin A and its initial isolation and characterization in 1965, a plethora of elegant molecular and ...
Varsha D. Shiragannavar, Nirmala G. Sannappa Gowda, Prasanna K. Santhekadur   +2 more
doaj   +1 more source

Withaferin A – A natural multifaceted therapeutic compound [PDF]

, 2021
COVID 19, which has lead to the death of millions of people, is still spreading worldwide. The development of any new drug after proper trial is much time consuming.  This present global pandemic situation has lead the researchers around the world ...
Senthil, Kalaiselvi, Vinod, Sangeetha
core   +1 more source