Results 41 to 50 of about 114,628,411 (160)

Vimentin as a potential therapeutic target in sorafenib resistant HepG2, a HCC model cell line [PDF]

Clinical and Molecular Hepatology, 2020
Background/Aims Hepatocellular carcinoma (HCC) is the most common liver cancer with high mortality rate in patients suffering from liver diseases. The drug of choice used in advanced-stage of HCC is sorafenib.
Ankita Makol, Harpreet Kaur, Sakshi Sharma, Shruthi Kanthaje, Ramanpreet Kaur, Anuradha Chakraborti   +5 more
doaj   +1 more source

An Adaptogen: Withaferin A Ameliorates in Vitro and in Vivo Pulmonary Fibrosis by Modulating the Interplay of Fibrotic, Matricelluar Proteins, and Cytokines

Frontiers in Pharmacology, 2018
Pulmonary fibrosis (PF) is chronic lung disease with only two FDA approved clinically available drugs, with limited safety profile. Inadequate therapy motivated us to explore the effect of vimentin inhibitor Withaferin A, as an anti-fibrotic agent ...
Swarna Bale, Pooladanda Venkatesh, Manoj Sunkoju, Chandraiah Godugu   +3 more
doaj   +1 more source

Withaferin A, a polyfunctional pharmacophore that includes covalent engagement of IPO5, is an inhibitor of influenza A replication

, 2022
Withaferin A, a natural steroidal lactone found in the extracts of Withania somnifera, is used extensively in traditional medicine and part of an ancient remedy in ayurvedic medicine.
Winssinger, Nicolas, Patouret, Rémi, Barluenga Badiola, Sofia   +2 more
core   +1 more source

Protective effect of Withaferin-A on micronucleus frequency and detoxication agents during experimental oral carcinogenesis [PDF]

, 2010
Our aim was to investigate the effect of Withaferin-A on bone marrow micronucleus frequency andbuccal mucosa detoxication agents during 7, 12–dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis.
N Senthil, L Alias, M Nirmal, Panjamurthy, K, Alias, L, K Panjamurthy, Suresh, K, Senthil, N, Manoharan, S, S Balakrishnan, K Suresh, Balakrishnan, S, Nirmal, M, S Manoharan   +13 more
core   +1 more source

Benefits of Withania somnifera (Ashwagandha) supplementation in obesity

Journal of Education, Health and Sport, 2023
Introduction and purpose: Ashwagandha (fam. Solanaceae) also known as Withania somnifera, is an herb commonly used in traditional Ayurvedic medicine. It is sometimes called Indian ginseng or winter cherry and it is used for its extensive health benefits
Alicja Nowak, Klaudia Bogusz, Natalia Baran, Marcela Maksymowicz, Adriana Bielak, Aleksandra Nowak, Łucja Cywka, Weronika Szwed, Piotr Machowiec   +8 more
doaj   +1 more source

Estimating the production of withaferin A and withanolide A in Withania somnifera (L.) dunal using aquaponics for sustainable development in hill agriculture

Frontiers in Plant Science, 2023
IntroductionHumanity is suffering from huge and severe difficulties, including changes in climate, soil degradation, scarcity of water and the security of food and medicines, among others.
Manali Singh, Shivani Bhutani, Nisha Dinkar, Anita Mishra, Kahkashan Perveen, Alanoud T. Alfagham, Mehrun Nisha Khanam, Santosh Chandra Bhatt, Deep Chandra Suyal   +8 more
doaj   +1 more source

Evaluation of the Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects of Withaferin A (WA) against Lipopolysaccharide (LPS)-Induced Inflammation in Immune Cells Derived from BALB/c Mice

Pharmaceutics, 2022
(1) Background: Inflammation is one of the primary responses of the immune system and plays a key role in the pathophysiology of various diseases. Recent reports suggest that various phytochemicals exhibit promising anti-inflammatory and immunomodulation
Abdullah M. Alnuqaydan, Abdulmajeed Almutary, Gh Rasool Bhat, Tanveer Ahmad Mir, Shadil Ibrahim Wani, Mohd Younis Rather, Shabir Ahmad Mir, Bader Alshehri, Sulaiman Alnasser, Faten M. Ali Zainy, Bilal Rah   +10 more
doaj   +1 more source

Withaferin A recovery in sWRE.

, 2013
sWRE powder was dissolved in different solvents and the concentration (A) and recovery rate (B) of Withaferin A in sWRE was measured by HPLC. The stability of Withaferin A in sWRE (90% EtOH stock solution) over time is shown in a bar graph with the ...
Doris R. Powell (457630), Songli Xu (457629), Anapatricia Garcia (457628), Paula M. Vertino (457631), Zhen Yang (107412), Adam I. Marcus (457633), Shivendra Singh (457632)   +6 more
core   +1 more source

ISOLATION AND CHARACTERIZATION OF WITHAFERIN-A FROM THE WITHANIA SOMNIFERA (ASHWAGANDHA) [PDF]

, 2017
The research work is related to an improved process of isolation & characterization of Withaferin-A from withania somnifera (Sanskrit: Ashawagandha, English: Winter cherry).
Rakesh Kumar Jat, Bali Reddy Keesara, Keesara, Bali Reddy, Jat, Rakesh Kumar   +3 more
core   +1 more source

Pharmacokinetics and bioequivalence of Withania somnifera (Ashwagandha) extracts – A double blind, crossover study in healthy adults

Heliyon, 2023
Introduction: Withania somnifera (WS) or ashwagandha is an adaptogenic plant used extensively in traditional medicines and as a food supplement. Despite a long history of use and numerous clinical trials, the human pharmacokinetics of withanolides, the ...
Se-Kwon Kim, Jayachandran Venkatesan, Priyank Rathi, Benny Antony   +3 more
doaj   +1 more source