Results 21 to 30 of about 3,431 (173)

Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane

Scientific Reports, 2021
Poor bioavailability due to the inability to cross the cell membrane is one of the major reasons for the failure of a drug in clinical trials. We have used molecular dynamics simulations to predict the membrane permeability of natural drugs—withanolides (
Renu Wadhwa, Neetu Singh Yadav, Shashank P. Katiyar, Tomoko Yaguchi, Chohee Lee, Hyomin Ahn, Chae-Ok Yun, Sunil C. Kaul, Durai Sundar   +8 more
doaj   +1 more source

Withaferin A Improves Nonalcoholic Steatohepatitis in Mice [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2019
Nonalcoholic steatohepatitis (NASH) is the progressive stage of nonalcoholic fatty liver disease that highly increases the risk of cirrhosis and liver cancer, and there are few therapeutic options available in the clinic. Withaferin A (WA), extracted from the ayurvedic medicine Withania somnifera, has a wide range of pharmacological activities; however,
Daxesh P, Patel, Tingting, Yan, Donghwan, Kim, Henrique B, Dias, Kristopher W, Krausz, Shioko, Kimura, Frank J, Gonzalez   +6 more
openaire   +2 more sources

Electrically Polarized Withaferin A and Alginate-Incorporated Biphasic Calcium Phosphate Microspheres Exhibit Osteogenicity and Antibacterial Activity In Vitro

Molecules, 2022
Biphasic calcium phosphate microspheres were synthesized by the water on oil emulsion method and, subsequently, withaferin A was incorporated in the microspheres to evaluate their efficacy in biomedical applications.
Itishree Priyadarshini, Subhasmita Swain, Janardhan Reddy Koduru, Tapash Ranjan Rautray   +3 more
doaj   +1 more source

Optimization of Elicitation Conditions to Enhance the Production of Potent Metabolite Withanolide from Withania somnifera (L.)

Metabolites, 2022
This study aimed at optimizing conditions for increased withanolide production in Withania somnifera. The elicitors used for the foliar spray on the aerial parts of the plant were salicylic acid, jasmonic acid, and chitosan for the enhancement of ...
Manali Singh, Sanjeev Agrawal, Obaid Afzal, Abdulmalik S. A. Altamimi, Alya Redhwan, Nawaf Alshammari, Mitesh Patel, Mohd Adnan, Abdelbaset Mohamed Elasbali, Shahanavaj Khan   +9 more
doaj   +1 more source

Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives

Biomedicines, 2020
Withaferin A (WA), a manifold studied, C28-steroidal lactone withanolide found in Withania somnifera. Given its unique beneficial effects, it has gathered attention in the era of modern science.
Tapan Behl, Aditi Sharma, Lalit Sharma, Aayush Sehgal, Gokhan Zengin, Roxana Brata, Ovidiu Fratila, Simona Bungau   +7 more
doaj   +1 more source

Estimating the production of withaferin A and withanolide A in Withania somnifera (L.) dunal using aquaponics for sustainable development in hill agriculture

Frontiers in Plant Science, 2023
IntroductionHumanity is suffering from huge and severe difficulties, including changes in climate, soil degradation, scarcity of water and the security of food and medicines, among others.
Manali Singh, Shivani Bhutani, Nisha Dinkar, Anita Mishra, Kahkashan Perveen, Alanoud T. Alfagham, Mehrun Nisha Khanam, Santosh Chandra Bhatt, Deep Chandra Suyal   +8 more
doaj   +1 more source

Withaferin A inhibits osteosarcoma cells through inactivation of Notch-1 signalling

Bangladesh Journal of Pharmacology, 2014
Human osteosarcoma cells were treated with withaferin A and the antiproliferative activity was evaluated by the 3-(4, 5 dimethyl-thiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays.
Yang Chen, Xiang-Zhen Han, Wei Wang, Ren-Tao Zhao, Xiao Li   +4 more
doaj   +1 more source

Withaferin A ameliorates ovarian cancer-induced cachexia and proinflammatory signaling

Journal of Ovarian Research, 2019
Background Ovarian cancer is the fifth leading cause of cancer-related deaths amongst women in the United States. Cachexia is the primary cause of death in approximately 30% of cancer patients, and is often evidenced in ovarian cancer patients. We tested
Alex R. Straughn, Sham S. Kakar
doaj   +1 more source

An Adaptogen: Withaferin A Ameliorates in Vitro and in Vivo Pulmonary Fibrosis by Modulating the Interplay of Fibrotic, Matricelluar Proteins, and Cytokines

Frontiers in Pharmacology, 2018
Pulmonary fibrosis (PF) is chronic lung disease with only two FDA approved clinically available drugs, with limited safety profile. Inadequate therapy motivated us to explore the effect of vimentin inhibitor Withaferin A, as an anti-fibrotic agent ...
Swarna Bale, Pooladanda Venkatesh, Manoj Sunkoju, Chandraiah Godugu   +3 more
doaj   +1 more source

Obesity: will withaferin win the war?

Nature Medicine, 2016
A new study shows that withaferin A, a steroidal lactone isolated from Withania somnifera, can exert profound metabolic benefits in mice, including body-weight loss, reduced hepatic steatosis and improved glucose control.
Paul T Pfluger, Matthias H Tschöp
openaire   +4 more sources