Results 31 to 40 of about 3,431 (173)
Withaferin A: From Ancient Remedy to Potential Drug Candidate [PDF]
Molecules, 2021 Withaferin A (WA) is a pivotal withanolide that has conquered a conspicuous place in research, owning to its multidimensional biological properties. It is an abundant constituent in Withania somnifera Dunal. (Ashwagandha, WS) that is one of the prehistoric pivotal remedies in Ayurveda.
Tahira Sultana +6 more
openaire +4 more sources
Evaluation of the geroprotective effects of withaferin A in Drosophila melanogaster
Aging, 2021 Withanolides are a class of compounds usually found in plant extracts which are an attractive geroprotective drug design starting point. We evaluated the geroprotective properties of Withaferin A (WA) in vivo using the Drosophila model. Flies were supplemented by nutrient medium with WA (at a concentration of 1, 10, or 100 μM dissolved in ethanol) for ...
Koval, Liubov +4 more
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Withaferin A for COVID-19: a Network Pharmacology Approach
Applied Biochemistry and Biotechnology, 2023 COVID-19 has become a global challenge as there are very few treatment options available. This has proved to impact several physiological implications like immunological injury, myocardial infarction, micro-thrombus formation, neurological complications and multi-organ dysfunction. A combination therapy or a systems pharmacology approach can be adopted
Ashasmita S. Mishra +3 more
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Vimentin as a potential therapeutic target in sorafenib resistant HepG2, a HCC model cell line [PDF]
Clinical and Molecular Hepatology, 2020 Background/Aims Hepatocellular carcinoma (HCC) is the most common liver cancer with high mortality rate in patients suffering from liver diseases. The drug of choice used in advanced-stage of HCC is sorafenib.
Ankita Makol +5 more
doaj +1 more source
Mediators of Inflammation, 2017 There are increasing evidences of proinflammatory cytokine involvement in cancer development. Here, we found that two cytokines, IL-6 and TNF-α, activated colorectal cancer cells to be more invasive and stem-like.
Seyung S. Chung +7 more
doaj +1 more source
Benefits of Withania somnifera (Ashwagandha) supplementation in obesity
Journal of Education, Health and Sport, 2023 Introduction and purpose: Ashwagandha (fam. Solanaceae) also known as Withania somnifera, is an herb commonly used in traditional Ayurvedic medicine. It is sometimes called Indian ginseng or winter cherry and it is used for its extensive health benefits
Alicja Nowak +8 more
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Withaferin-A inhibits colorectal cancer growth and metastasis by targeting the HSP90/HIF-1α/EMT axis
Archives of Medical ScienceIntroduction Withaferin-A (WA) derived from natural products can inhibit the growth and metastasis of colorectal cancer (CRC) in vitro and in vivo. Transcriptome sequencing showed that WA inhibited the epithelial-mesenchymal transition pathway (EMT ...
Wen-qi Lu +6 more
doaj +1 more source
Inhibition of Monosodium Urate Crystal-Induced Inflammation by Withaferin A
Journal of Pharmacy & Pharmaceutical Sciences, 2009 Purpose. Gouty arthritis is a characteristically intense acute inflammatory reaction resulting from the formation of sodium urate crystals in the joint cavity.
Mahaboobkhan Rasool +2 more
doaj +1 more source
Pharmaceutics, 2022 (1) Background: Inflammation is one of the primary responses of the immune system and plays a key role in the pathophysiology of various diseases. Recent reports suggest that various phytochemicals exhibit promising anti-inflammatory and immunomodulation
Abdullah M. Alnuqaydan +10 more
doaj +1 more source
Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition. [PDF]
PLoS ONE, 2013 Though clinicians can predict which patients are at risk for developing metastases, traditional therapies often prove ineffective and metastatic disease is the primary cause of cancer patient death; therefore, there is a need to develop anti-metastatic ...
Zhen Yang +6 more
doaj +1 more source