Results 81 to 90 of about 3,431 (173)

Radiosensitizing effects of Withaferin A in gastric cancer cells via autophagy Inhibition and mitochondrial disruption

Scientific Reports
Gastric cancer is highly lethal due to late-stage diagnosis and resistance to standard treatments like radiotherapy. Enhancing radiosensitivity in gastric cancer cells could improve treatment outcomes.
Ping Lu, Juan Xue, Xuemeng JI
doaj   +1 more source

Withaferin A as a Multi-Target Anti-Marburg Candidate against Marburg Virus: an

In Silico Research in Biomedicine
Marburg virus (MARV), a highly virulent filovirus of the Filoviridae family, causes severe hemorrhagic fever associated with high case-fatality rates, while effective therapeutic options remain limited. The identification of novel antiviral candidates is
Farayed Ahamed Nabil, Abu Darda, Kazi Md. Ali Zinnah, Ferdaus Mohd Altaf Hossain, Ehsanul Islam   +4 more
doaj   +1 more source

Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression

Journal of Experimental & Clinical Cancer Research
Background Aberrant glycogen metabolism drives lipid accumulation and adaptive lipid homeostasis reprogramming, a metabolic adaptation critical for sustaining malignant progression and chemoresistance in cholangiocarcinoma (CCA).
Yani Pan, Nannan Zhang, Xueni Fu, Xinyu Wang, Yichun Ma, Qi Chen, Yue Zhou, Hongwen Liu, Yun Zhu, Lei Xu, Qiang Wang, Dongyin Chen, Zhangding Wang, Lei Wang   +13 more
doaj   +1 more source

Discovery of MYC/NSD3S Protein-Protein Interaction Negative Modulators with a Live Cell Nanoluciferase Protein-Fragment Complementation uHTS Assay. [PDF]

ACS Omega
Vera-Molina S, Acosta-Yanez D, Olivera E, Romero-Vera E, Farkas C, Hepp MI, Salas-Burgos A, Du Y, Gonzalez-Pecchi V.   +8 more
europepmc   +1 more source

Pan-cancer profiles of mesothelin (MSLN) unveil diagnostic potential and therapeutic targetability of pancreatic adenocarcinoma. [PDF]

PLoS One
Sheikh MR, Mistry B, Shafin RH, Apu A, Sara TH, Tasnim J, Dutta D, Nandy A, Rahman A.   +8 more
europepmc   +1 more source

Differential Cytoskeletal Control of Cell-Collagen Mechanics in High- and Low-Flow Glaucomatous Trabecular Meshwork Cells. [PDF]

ACS Appl Mater Interfaces
Karimi A, Golchin H, Adamec M, Stanik A, Nandakumar P, Ganesan M, Aga M, White E, Kelley MJ, Acott T.   +9 more
europepmc   +1 more source

Chitosan activates a sequential Ca ^<b>2+</b> -ROS-NO-jasmonate signaling cascade governing withanolide accumulation in <i>Withania somnifera</i>. [PDF]

Plant Signal Behav
Perveen S, Haider I, Mahmood A, Rehman SU, Nadeem MY, Zaheer A, Herqash RN, Noman OM, Alanzi AR.   +8 more
europepmc   +1 more source

Withanolides Are Detected in Human Urine Following Oral Administration of a <i>Withania somnifera</i> Product. [PDF]

Int J Mol Sci
Speers AB, Limoico ED, Lozano-Ortiz A, Marney L, Choi J, Barr SA, Williamson RT, Strangman WK, Maier CS, Soumyanath A.   +9 more
europepmc   +1 more source

Systematic Proteome-wide Mendelian Randomization to Identify Novel Therapeutic Targets for Age-related Hearing Loss. [PDF]

J Otol
Zhang K, Li Z, Wang L, Xin X, Qiu X, Qu P, Dong D, Zhang H.   +7 more
europepmc   +1 more source

Nutraceutical Applications of <i>Withania somnifera</i>: The Scientific Knowledge for Rational Modern Use of the "Ayurvedic Adaptogen". [PDF]

Foods
Pandey S, Pant P, Corbioli G, Bonazzi E, Cisneros-Yupanqui M, Salmaso P, Dall'Acqua S.   +6 more
europepmc   +1 more source