Results 71 to 80 of about 3,431 (173)

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Therapeutic Potential of Withaferin-A and Propolis Combinational Drug Therapy for Breast Cancer: An In Vivo Interpretation for Validating the Antiproliferative Efficacy and Ameliorative Potential in Benzo[a]pyrene-Induced Breast Metastasis

Journal of Chemistry
Cancer is a serious health problem, with a rising trend in its occurrence documented globally. Female breast cancer is the most common type of cancer worldwide with treatment consisting of different strategies like mastectomy, chemotherapy, and ...
Meghalatha T. S., Arumugam Suresh, Muninathan Natrajan, Kuppusamy Baskaran, Shobana Sampath, Elumalai Perumal, E. Madhav, Mohammad Z. Ahmed, Ali S. Alqahtani, Shadab Kazmi, Asaithambi Perumal   +10 more
doaj   +1 more source

Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes

Neural Plasticity, 2015
Several lines of evidence suggest that astrocytes play a key role in modulating the immune responses of the central nervous system (CNS) to infections, injuries, or pathologies. Yet, their contribution to these processes remains mostly elusive. Astroglia
Francesca Martorana, Giulia Guidotti, Liliana Brambilla, Daniela Rossi   +3 more
doaj   +1 more source

Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A

BMC Bioinformatics, 2011
Background Herpes Simplex Virus 1 and 2 causes several infections in humans including cold sores and encephalitis. Previous antiviral studies on herpes viruses have focussed on developing nucleoside analogues that can inhibit viral polymerase and ...
Grover Abhinav, Agrawal Vibhuti, Shandilya Ashutosh, Bisaria Virendra S, Sundar Durai   +4 more
doaj   +1 more source

Optimization of Carbon Source for Hairy Root Growth and Withaferin A and Withanone Production in

Natural Product Communications, 2012
This study optimized carbon sources in half MS liquid medium for maximum biomass accumulation and withanolides production in hairy root culture of Withania somnifera .
Ganeshan Sivanandhan, Manoharan Rajesh, Muthukrishnan Arun, Murugaraj Jeyaraj, Gnanajothi Kapil Dev, Markandan Manickavasagam, Natesan Selvaraj, Andy Ganapathi   +7 more
doaj   +1 more source

Computational discovery of natural inhibitors targeting enterovirus D68 3C protease using molecular docking pharmacokinetics and dynamics simulations

Scientific Reports
Enterovirus D68 (EV-D68) is a significant global health threat, responsible for severe respiratory and neurological complications, with no FDA-approved antiviral treatments currently available.
Mansoor Alsahag
doaj   +1 more source

Glioblastoma Stem Cells and Withaferin A, A Review [PDF]

Biomedical Journal of Scientific & Technical Research, 2019
Glioblastoma multiforme is characterized by tumor cell heterogeneity, and by recurrent invasive tumors following conventional radiation, cytotoxic drugs, and limited ablative surgery [1-5]...
openaire   +1 more source

Withaferin A decreases glycolytic reprogramming in breast cancer

Scientific Reports
Reprogrammed glucose metabolism is considered as the hallmark of cancer with therapeutic implications. Phytocompounds have potential to inhibit cancer metabolism. Here, we tested the ability of Withaferin A (WA), a withanolide derived from Withania somnifera, in modulating cancer metabolism.
Asifa Khan, Asad ur Rehman, Shumaila Siddiqui, Jiyauddin Khan, Sheersh Massey, Prithvi Singh, Daman Saluja, Syed Akhtar Husain, Mohammad Askandar Iqbal   +8 more
openaire   +3 more sources

Implications of Withaferin A in neurological disorders

Neural Regeneration Research, 2020
Natasha Ram, Stephanie L. Peak, Andres R. Perez, Umesh K. Jinwal   +3 more
openaire   +3 more sources