Results 21 to 30 of about 102,615,988 (206)

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal [PDF]

Pharmaceuticals, 2023
Cancer represents the second most deadly disease and one of the most important public health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy are the major types of treatment strategies that have been implemented in cancer
Suneel Kumar, Stephen O. Mathew, Ravindra Prasad Aharwal, Hardeep Singh Tulli, Chakrabhavi Dhananjaya Mohan, Gautam Sethi, Kwang-Seok Ahn, Kassidy Webber, Sardul Singh Sandhu, Anupam Bishayee   +9 more
doaj   +2 more sources

Estimation of Withaferin-A by HPLC and standardization of the Ashwagandhadi lehyam formulation

Heliyon, 2021
Standardization is an important measurement for ensuring the quality control of herbal drugs. It has become essential to develop reliable, specific and sensitive quality control methods.
Ajay Kumar Meena, P. Rekha, Ayyam Perumal, M. Gokul, K.N. Swathi, R. Ilavarasan   +5 more
doaj   +3 more sources

Inhibition of Monosodium Urate Crystal-Induced Inflammation by Withaferin A

Journal of Pharmacy & Pharmaceutical Sciences, 2009
Purpose. Gouty arthritis is a characteristically intense acute inflammatory reaction resulting from the formation of sodium urate crystals in the joint cavity.
Mahaboobkhan Rasool, Sonal Chandal, Evan Prince Sabina   +2 more
doaj   +2 more sources

Overview of Ayurveda and Ashwagandha: Bioactive Phytochemicals and Potential Applications to Gliomas [PDF]

Molecules
Ayurveda is the traditional medical system of India and has been in use for more than 5000 years. The focus of Ayurveda is to maintain harmony and balance of the three Doshas (Vata, Pitta, Kapha), or life forces, that govern the physiology and health of ...
Herbert B. Newton
doaj   +2 more sources

Computational discovery of natural inhibitors targeting enterovirus D68 3C protease using molecular docking pharmacokinetics and dynamics simulations [PDF]

Scientific Reports
Enterovirus D68 (EV-D68) is a significant global health threat, responsible for severe respiratory and neurological complications, with no FDA-approved antiviral treatments currently available.
Mansoor Alsahag
doaj   +2 more sources

Network pharmacology and in-silico studies for molecular mechanisms of analgesic, anti-inflammatory and anti-arthritic effects of Withania somnifera (L.) Dunal phytoconstituents [PDF]

Journal of Ayurveda and Integrative Medicine
Background: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is an Ayurvedic herb belonging to the family Solanaceae. Objectives: This study aims to explore the analgesic, anti-inflammatory and anti-arthritic potential of phytoconstituents ...
Mukul S. Tambe, Shreyas R. Shinde, Akshay M. Baheti, Shuchi Nagar, Anil T. Pawar   +4 more
doaj   +2 more sources

Randomized, Double-Blind, Crossover Study Comparing the Bioavailability of 4 Ashwagandha (Withania somnifera (L.) Dunal) Extracts in Healthy Adults Under Fasting Condition [PDF]

Current Therapeutic Research
Background: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is a well-known plant in ayurvedic medicine, widely valued for its therapeutic potential. Although numerous clinical studies have explored its diverse health benefits, limited data
Priyank Rathi, MD, Se-Kwon Kim, PhD
doaj   +2 more sources

Ashwagandha Root Extract and Its Potential Modulation of CCN1‐Associated Pathways in Sensitive‐Skin Aging [PDF]

J Cosmet Dermatol
ABSTRACT Background Cellular Communication Network Factor 1 (CCN1) has been identified as a key regulator of oxidative stress‐induced skin aging and sensitivity. Ashwagandha root extract (ARE) is a promising candidate for modulating CCN1‐associated pathways. Aims To investigate whether ARE can mitigate sensitive‐skin aging by modulating CCN1 expression
Kang L, Liu Y, Xin Y, Geng L, Cai S, Luo J, Gu S, Wang S, Zhang Z, Huang Y, Zhou G, Ye L, Li D, Jiang N.   +13 more
europepmc   +2 more sources

Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC

Frontiers in Oncology, 2021
Withaferin A, a steroidal lactone derived from the Withania somnifera plant has been known for its anti-cancerous effects on various types of cancer cells.
Varsha D. Shiragannavar, Nirmala G. Sannappa Gowda, Divya P. Kumar, Faridoddin Mirshahi, Prasanna K. Santhekadur   +4 more
doaj   +1 more source

Discovery of eukaryotic cellular receptor for Withaferin A, a multifaceted drug from Withania somnifera plant

Medicine in Drug Discovery, 2022
Withaferin A is a dietary natural compound from a very popular Ayurvedic plant called Ashwagandha (Withania Somnifera). Since the discovery of Withaferin A and its initial isolation and characterization in 1965, a plethora of elegant molecular and ...
Varsha D. Shiragannavar, Nirmala G. Sannappa Gowda, Prasanna K. Santhekadur   +2 more
doaj   +1 more source