Results 41 to 50 of about 102,615,988 (206)

Withaferin A Improves Nonalcoholic Steatohepatitis in Mice [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2019
Nonalcoholic steatohepatitis (NASH) is the progressive stage of nonalcoholic fatty liver disease that highly increases the risk of cirrhosis and liver cancer, and there are few therapeutic options available in the clinic. Withaferin A (WA), extracted from the ayurvedic medicine Withania somnifera, has a wide range of pharmacological activities; however,
Daxesh P, Patel, Tingting, Yan, Donghwan, Kim, Henrique B, Dias, Kristopher W, Krausz, Shioko, Kimura, Frank J, Gonzalez   +6 more
openaire   +2 more sources

Withaferin A, a polyfunctional pharmacophore that includes covalent engagement of IPO5, is an inhibitor of influenza A replication

, 2022
Withaferin A, a natural steroidal lactone found in the extracts of Withania somnifera, is used extensively in traditional medicine and part of an ancient remedy in ayurvedic medicine.
Winssinger, Nicolas, Patouret, Rémi, Barluenga Badiola, Sofia   +2 more
core   +1 more source

An Adaptogen: Withaferin A Ameliorates in Vitro and in Vivo Pulmonary Fibrosis by Modulating the Interplay of Fibrotic, Matricelluar Proteins, and Cytokines

Frontiers in Pharmacology, 2018
Pulmonary fibrosis (PF) is chronic lung disease with only two FDA approved clinically available drugs, with limited safety profile. Inadequate therapy motivated us to explore the effect of vimentin inhibitor Withaferin A, as an anti-fibrotic agent ...
Swarna Bale, Pooladanda Venkatesh, Manoj Sunkoju, Chandraiah Godugu   +3 more
doaj   +1 more source

Protective effect of Withaferin-A on micronucleus frequency and detoxication agents during experimental oral carcinogenesis [PDF]

, 2010
Our aim was to investigate the effect of Withaferin-A on bone marrow micronucleus frequency andbuccal mucosa detoxication agents during 7, 12–dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis.
N Senthil, L Alias, M Nirmal, Panjamurthy, K, Alias, L, K Panjamurthy, Suresh, K, Senthil, N, Manoharan, S, S Balakrishnan, K Suresh, Balakrishnan, S, Nirmal, M, S Manoharan   +13 more
core   +1 more source

Benefits of Withania somnifera (Ashwagandha) supplementation in obesity

Journal of Education, Health and Sport, 2023
Introduction and purpose: Ashwagandha (fam. Solanaceae) also known as Withania somnifera, is an herb commonly used in traditional Ayurvedic medicine. It is sometimes called Indian ginseng or winter cherry and it is used for its extensive health benefits
Alicja Nowak, Klaudia Bogusz, Natalia Baran, Marcela Maksymowicz, Adriana Bielak, Aleksandra Nowak, Łucja Cywka, Weronika Szwed, Piotr Machowiec   +8 more
doaj   +1 more source

Evaluation of the geroprotective effects of withaferin A in Drosophila melanogaster

Aging, 2021
Withanolides are a class of compounds usually found in plant extracts which are an attractive geroprotective drug design starting point. We evaluated the geroprotective properties of Withaferin A (WA) in vivo using the Drosophila model. Flies were supplemented by nutrient medium with WA (at a concentration of 1, 10, or 100 μM dissolved in ethanol) for ...
Koval, Liubov, Zemskaya, Nadezhda, Aliper, Alexander, Zhavoronkov, Alex, Moskalev, Alexey   +4 more
openaire   +2 more sources

Estimating the production of withaferin A and withanolide A in Withania somnifera (L.) dunal using aquaponics for sustainable development in hill agriculture

Frontiers in Plant Science, 2023
IntroductionHumanity is suffering from huge and severe difficulties, including changes in climate, soil degradation, scarcity of water and the security of food and medicines, among others.
Manali Singh, Shivani Bhutani, Nisha Dinkar, Anita Mishra, Kahkashan Perveen, Alanoud T. Alfagham, Mehrun Nisha Khanam, Santosh Chandra Bhatt, Deep Chandra Suyal   +8 more
doaj   +1 more source

Evaluation of the Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects of Withaferin A (WA) against Lipopolysaccharide (LPS)-Induced Inflammation in Immune Cells Derived from BALB/c Mice

Pharmaceutics, 2022
(1) Background: Inflammation is one of the primary responses of the immune system and plays a key role in the pathophysiology of various diseases. Recent reports suggest that various phytochemicals exhibit promising anti-inflammatory and immunomodulation
Abdullah M. Alnuqaydan, Abdulmajeed Almutary, Gh Rasool Bhat, Tanveer Ahmad Mir, Shadil Ibrahim Wani, Mohd Younis Rather, Shabir Ahmad Mir, Bader Alshehri, Sulaiman Alnasser, Faten M. Ali Zainy, Bilal Rah   +10 more
doaj   +1 more source

Design and synthesis of new withaferin A inspired hedgehog pathway inhibitors [PDF]

, 2021
Withanolides constitute a well-known family of plant-based alkaloids characterised by widespread biological properties, including the ability of interfering with Hedgehog (Hh) signalling pathway.
Basili I., Passarella D., Mori M., Bonandi E., Calcaterra A., Botta B., Infante P., Catti F., Di Marcotullio L.   +8 more
core   +1 more source

Withaferin A for COVID-19: a Network Pharmacology Approach

Applied Biochemistry and Biotechnology, 2023
COVID-19 has become a global challenge as there are very few treatment options available. This has proved to impact several physiological implications like immunological injury, myocardial infarction, micro-thrombus formation, neurological complications and multi-organ dysfunction. A combination therapy or a systems pharmacology approach can be adopted
Ashasmita S. Mishra, Bhuvaneswari Varadarajan, Srayaa Sathish, Sujata Roy   +3 more
openaire   +2 more sources