Results 51 to 60 of about 102,615,988 (206)

Withaferin A recovery in sWRE.

, 2013
sWRE powder was dissolved in different solvents and the concentration (A) and recovery rate (B) of Withaferin A in sWRE was measured by HPLC. The stability of Withaferin A in sWRE (90% EtOH stock solution) over time is shown in a bar graph with the ...
Doris R. Powell (457630), Songli Xu (457629), Anapatricia Garcia (457628), Paula M. Vertino (457631), Zhen Yang (107412), Adam I. Marcus (457633), Shivendra Singh (457632)   +6 more
core   +1 more source

ISOLATION AND CHARACTERIZATION OF WITHAFERIN-A FROM THE WITHANIA SOMNIFERA (ASHWAGANDHA) [PDF]

, 2017
The research work is related to an improved process of isolation & characterization of Withaferin-A from withania somnifera (Sanskrit: Ashawagandha, English: Winter cherry).
Rakesh Kumar Jat, Bali Reddy Keesara, Keesara, Bali Reddy, Jat, Rakesh Kumar   +3 more
core   +1 more source

Pharmacokinetics and bioequivalence of Withania somnifera (Ashwagandha) extracts – A double blind, crossover study in healthy adults

Heliyon, 2023
Introduction: Withania somnifera (WS) or ashwagandha is an adaptogenic plant used extensively in traditional medicines and as a food supplement. Despite a long history of use and numerous clinical trials, the human pharmacokinetics of withanolides, the ...
Se-Kwon Kim, Jayachandran Venkatesan, Priyank Rathi, Benny Antony   +3 more
doaj   +1 more source

Withaferin A Analogs That Target the AAA+ Chaperone p97 [PDF]

ACS Chemical Biology, 2015
Understanding the mode of action (MOA) of many natural products can be puzzling with mechanistic clues that seem to lack a common thread. One such puzzle lies in the evaluation of the antitumor properties of the natural product withaferin A (WFA). A variety of seemingly unrelated pathways have been identified to explain its activity, suggesting a lack ...
Shasha, Tao, Joseph, Tillotson, E M Kithsiri, Wijeratne, Ya-Ming, Xu, MinJin, Kang, Tongde, Wu, Eric C, Lau, Celestina, Mesa, Damian J, Mason, Robert V, Brown, James J La, Clair, A A Leslie, Gunatilaka, Donna D, Zhang, Eli, Chapman   +13 more
openaire   +2 more sources

Enhanced production of withaferin - a in shoot cultures of Withania somnifera (L) Dunal [PDF]

, 2014
Withania somnifera (L) Dunal, commonly known as ashwagandha or Indian ginseng, is the source of large number of pharmacologically active withanolides. Withaferin-A (WS-3), a major withanolide of W.
Koul, Sushma, Khazir, Jabeena, Cowan, Don A., Hakeem, Khalid Rehman, Mir, Bilal Ahmad, Hakeem, Khalid R.   +5 more
core   +1 more source

Supplementary Figure from Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors

, 2023
Supplementary Figure from Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary ...
Krishna B. Singh (15111017), Shivendra V. Singh (15111026), Eun-Ryeong Hahm (15111020), Su-Hyeong Kim (15111023)   +3 more
core   +3 more sources

Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells

Mediators of Inflammation, 2017
There are increasing evidences of proinflammatory cytokine involvement in cancer development. Here, we found that two cytokines, IL-6 and TNF-α, activated colorectal cancer cells to be more invasive and stem-like.
Seyung S. Chung, Yong Wu, Quincy Okobi, Debbie Adekoya, Mohammad Atefi, Orette Clarke, Pranabananda Dutta, Jaydutt V. Vadgama   +7 more
doaj   +1 more source

Withaferin A: a potential therapeutic agent against COVID-19 infection

Journal of Ovarian Research, 2020
The outbreak and continued spread of the novel coronavirus disease 2019 (COVID-19) is a preeminent global health threat that has resulted in the infection of over 11.5 million people worldwide.
Alex R. Straughn, Sham S. Kakar
doaj   +1 more source

Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine

Molecules, 2009
Withania somnifera, commonly known as Ashwagandha, is an important medicinal plant that has been used in Ayurvedic and indigenous medicine for over 3,000 years.
Javier Palazón, Rosa M. Cusido, Mercedes Bonfill, Elisabeth Moyano, Mohammad Hossein Mirjalili   +4 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source