Results 31 to 40 of about 118,549,391 (165)

Withaferin A – A natural multifaceted therapeutic compound [PDF]

, 2021
COVID 19, which has lead to the death of millions of people, is still spreading worldwide. The development of any new drug after proper trial is much time consuming.  This present global pandemic situation has lead the researchers around the world ...
Senthil, Kalaiselvi, Vinod, Sangeetha, Kalaiselvi Senthil, Sangeetha Vinod   +3 more
core   +1 more source

The ameliorating effect of withaferin A on high-fat diet-induced non-alcoholic fatty liver disease by acting as an LXR/FXR dual receptor activator

Frontiers in Pharmacology, 2023
Introduction: Non-alcoholic fatty liver disease (NAFLD) incidence has been rapidly increasing, and it has emerged as one of the major diseases of the modern world.
Varsha D. Shiragannavar, Nirmala G. Sannappa Gowda, Lakshana D. Puttahanumantharayappa, Shreyas H. Karunakara, Smitha Bhat, Shashanka K. Prasad, Shashanka K. Prasad, Divya P. Kumar, Prasanna K. Santhekadur   +8 more
doaj   +1 more source

Plant Part–Specific Differences in Ashwagandha (Withania somnifera): A Comparative Evaluation of Root and Leaf Evidence for Safety and Regulation [PDF]

Food Sci Nutr
This review contrasts the root and leaf of Withania somnifera (ashwagandha) across phytochemistry, clinical evidence, and regulatory context. Root preparations are dominated by withanolide A, D, and glyco‐withanolides, with multiple randomized controlled trials supporting reductions in stress, anxiety, and insomnia alongside a favorable safety profile.
Dutta A, Gupta J.
europepmc   +2 more sources

Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. [PDF]

PLoS ONE, 2010
BACKGROUND:Vimentin is a ubiquitous mesenchymal intermediate filament supporting mechano-structural integrity of quiescent cells while participating in adhesion, migration, survival, and cell signaling processes via dynamic assembly/disassembly in ...
Guy Lahat, Quan-Sheng Zhu, Kai-Lieh Huang, Suizhao Wang, Svetlana Bolshakov, Jeffery Liu, Keila Torres, Robert R Langley, Alexander J Lazar, Mien Chie Hung, Dina Lev   +10 more
doaj   +1 more source

Electrically Polarized Withaferin A and Alginate-Incorporated Biphasic Calcium Phosphate Microspheres Exhibit Osteogenicity and Antibacterial Activity In Vitro

Molecules, 2022
Biphasic calcium phosphate microspheres were synthesized by the water on oil emulsion method and, subsequently, withaferin A was incorporated in the microspheres to evaluate their efficacy in biomedical applications.
Itishree Priyadarshini, Subhasmita Swain, Janardhan Reddy Koduru, Tapash Ranjan Rautray   +3 more
doaj   +1 more source

Optimization of Elicitation Conditions to Enhance the Production of Potent Metabolite Withanolide from Withania somnifera (L.)

Metabolites, 2022
This study aimed at optimizing conditions for increased withanolide production in Withania somnifera. The elicitors used for the foliar spray on the aerial parts of the plant were salicylic acid, jasmonic acid, and chitosan for the enhancement of ...
Manali Singh, Sanjeev Agrawal, Obaid Afzal, Abdulmalik S. A. Altamimi, Alya Redhwan, Nawaf Alshammari, Mitesh Patel, Mohd Adnan, Abdelbaset Mohamed Elasbali, Shahanavaj Khan   +9 more
doaj   +1 more source

Withaferin-A compound targeting α-amylase Suppl.files

, 2022
Withaferin-A compound targeting α ...
Aziz Unnisa
core   +1 more source

Nanoencapsulation of Withaferin-A for the Treatment of Neurological Disorder [PDF]

, 2022
A better delivery mechanism is ensured by a superior formulation. This study is based on the fact that people believe in natural products more than chemical products.
Sonu Sharma, Dr. Viney Lather, Dr. Vikram Sharma
core   +2 more sources

Withaferin A downregulates COX-2/NF-κB signaling and modulates MMP-2/9 in experimental endometriosis [PDF]

, 2022
Purpose: To study the effect of withaferin A on an experimentally-induced endometriosis (EM) model. Methods: Female Sprague-Dawley rats were induced EM by implantation of autologous endometrium.
Huimin, Wang, Dan, Wang, Xiaoxin, Yang, Yiling, Jiang, Jing, Fan, Chun, Li, Wang Huimin, Wang Dan, Jiang Yiling, Li Chun, Fan Jing, Yang Xiaoxin   +11 more
core   +1 more source

Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane

Scientific Reports, 2021
Poor bioavailability due to the inability to cross the cell membrane is one of the major reasons for the failure of a drug in clinical trials. We have used molecular dynamics simulations to predict the membrane permeability of natural drugs—withanolides (
Renu Wadhwa, Neetu Singh Yadav, Shashank P. Katiyar, Tomoko Yaguchi, Chohee Lee, Hyomin Ahn, Chae-Ok Yun, Sunil C. Kaul, Durai Sundar   +8 more
doaj   +1 more source