Results 71 to 80 of about 81,875,801 (209)

Ashwagandha Root Extract and Its Potential Modulation of CCN1‐Associated Pathways in Sensitive‐Skin Aging [PDF]

J Cosmet Dermatol
ABSTRACT Background Cellular Communication Network Factor 1 (CCN1) has been identified as a key regulator of oxidative stress‐induced skin aging and sensitivity. Ashwagandha root extract (ARE) is a promising candidate for modulating CCN1‐associated pathways. Aims To investigate whether ARE can mitigate sensitive‐skin aging by modulating CCN1 expression
Kang L, Liu Y, Xin Y, Geng L, Cai S, Luo J, Gu S, Wang S, Zhang Z, Huang Y, Zhou G, Ye L, Li D, Jiang N.   +13 more
europepmc   +2 more sources

Broad-spectrum antitumor properties of Withaferin A: a proteomic perspective

RSC Medicinal Chemistry, 2020
A review discussing the broad-spectrum antitumor properties of the natural steroid Withaferin A based on the binding with its true cancer protein targets: a defined stress dependent and stress independent mode of action.
Martin Dom, Wim Vanden Berghe, Xaveer Van Ostade   +2 more
openaire   +4 more sources

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Rapid and sensitive method for determination of withaferin-A in human plasma by HPLC

, 2011
Background: To develop and validate a rapid and sensitive high-performance liquid chromatographic method for determination of withaferin-A in human plasma.
Pankaj Patial, Vikram Gota
core   +1 more source

Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.
ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen, Tao‐Tao Shi, Dan‐Yang Hu, Xiao‐Na Su, Jian‐Xiang Jin, Mao‐Song Chen, Hao Wang, Wei Chen   +7 more
wiley   +1 more source

ISOLATION AND CHARACTERIZATION OF WITHAFERIN-A FROM THE WITHANIA SOMNIFERA (ASHWAGANDHA)

, 2017
The research work is related to an improved process of isolation & characterization of Withaferin-A from withania somnifera (Sanskrit: Ashawagandha, English: Winter cherry).
Rakesh Kumar Jat, Bali Reddy Keesara, Keesara, Bali Reddy, Jat, Rakesh Kumar   +3 more
core   +2 more sources

Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice [PDF]

Nature Medicine, 2016
The increasing global prevalence of obesity and its associated disorders points to an urgent need for the development of novel and effective therapeutic strategies that induce healthy weight loss. Obesity is characterized by hyperleptinemia and central leptin resistance.
Lee, Jaemin, Feng, Xudong, Ozcan, Umut, Liu, Junli, Salazar Hernández, Mario Andrés, Mucka, Patrick, Ibi, Dorina, Choi, Jae Won   +7 more
openaire   +4 more sources

Genetic and Withaferin A Analysis of Iranian Natural Populations of and by RAPD and HPTLC

Natural Product Communications, 2009
For successful conservation and breeding of a medicinal species, it is important to evaluate its genetic diversity as well as its content of phytochemical compounds. The aim of the present study was to investigate the genetic variation of Iranian natural
Mohammad Hossein Mirjalili, Seyyed Mohammad Fakhr-Tabatabaei, Houshang Alizadeh, Alireza Ghassempour, Fateme Mirzajani   +4 more
doaj   +1 more source

Evaluation of Withaferin A Content in Withania somnifera Using NMR and HPLC: A Comparative Assessment of Traditional and PCSL Extraction Methods

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
A comparative evaluation of traditional aqueous extractions and innovative pressurised cyclic solid–liquid extraction is presented for Withania somnifera leaves. Quantitative NMR, validated by HPLC, reveals a markedly enhanced preservation and recovery of withaferin A using PCSL.
Silvana Pedatella, Maria Chiara Di Meo, Daniele Naviglio, Gionata De Vico, Armando Zarrelli   +4 more
wiley   +1 more source

Mechanistic Elucidation of the Antitumor Properties of Withaferin A in Breast Cancer [PDF]

Cancer Research, 2014
Abstract Withaferin A (WFA) is a steroidal lactone with antitumor effects manifested at multiple levels that are mechanistically obscure. Using a phospho-kinase screening array, we discovered that WFA activated phosphorylation of the S6 kinase RSK (ribosomal S6 kinase) in breast cancer cells.
Arumugam, Nagalingam, Panjamurthy, Kuppusamy, Shivendra V, Singh, Dipali, Sharma, Neeraj K, Saxena   +4 more
openaire   +2 more sources