Results 81 to 90 of about 81,875,801 (209)
p53, a target of withanone and withaferin A.
, 2013 Docking of withanone (Wi-N) (A) and withaferin A (Wi-A) (B) to p53. (C) Imaging of p53 in human cancer (U2OS) cells treated with various concentrations of Wi-N and Wi-A.
M. Uthayakumar (308967) +9 more
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Vacuolization as a Novel Approach to Cancer Therapy
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak +9 more
wiley +1 more source
Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek +3 more
wiley +1 more source
Natural Monoterpene Stylosin Induced Anticancer Effects on Human Colon Carcinoma Cells
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.Extraction of STL from Ferula ovina by TLC and structural confirmation by 1H NMR. Favorable pharmacokinetics. Reduced CRC cell viability in a time‐ and dose‐dependent manner. Induced apoptosis. Interacted with the active site of HGFR. ABSTRACT Colorectal carcinoma (CRC) ranks among the top five most common malignancies globally, characterized by a high
Sara Seyedshazileh +3 more
wiley +1 more source
, 2013 Withaferin-A dose-dependently (10 tob40 mg/kg) displayed anxiolytic activity, as measured by an increase in open arm exploration time in the elevated plus-maze (EPM), following intraperitoneal (i.p.) administration in rats.
Ghosh, AR, Khan, ZA
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Effect of withanone and withaferin A purified from WSWE on S. globosa cells.
, 2022 [A, B] Mirror HPLC chromatograms of standard mix (black) and purified withanone (blue) (A)/withaferin A (B) recorded at 227 nm. [C, D] Dose response curves of withanone (A) and withaferin A (B) demonstrating anti-sporotrichotic effects against S. globosa
Acharya Balkrishna (5640038) +5 more
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ChemMedChem, Volume 21, Issue 9, 14 May 2026.From modular COF design to biomedical translation, this Review maps how linkage chemistry, topology, pore environment, and particle engineering govern bioperformance, therapeutic and diagnostic function, safety, and clinical readiness. Covalent organic frameworks (COFs) are a versatile class of crystalline porous materials with growing potential in ...
Julia Kolodziejczyk +1 more
wiley +1 more source
Advanced Science, Volume 13, Issue 25, 4 May 2026.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
Chemical structures of withanone and withaferin A.
, 2013 Withanone is a C6, C7 epoxy compound (colored red) that has hydroxyl groups (colored green) on C5 and C17. On the other hand, withaferin A is a C5, C6 epoxy compound (colored red) with hydroxyl groups on C4 and C27 (colored green).
M. Uthayakumar (308967) +9 more
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Supplementary Table from Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors
, 2023 Supplementary Table from Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary ...
Krishna B. Singh (15111017) +3 more
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