Results 91 to 100 of about 315,126 (245)
WNT Signaling in Cardiac and Vascular Disease
Pharmacological Reviews, 2018 WNT signaling is an elaborate and complex collection of signal transduction pathways mediated by multiple signaling molecules. WNT signaling is critically important for developmental processes, including cell proliferation, differentiation and tissue ...
S. Foulquier +5 more
semanticscholar +1 more source
Stimulation of epidermal hyperplasia and tumorigenesis by resident p16INK4a-expressing cells
Molecular & Cellular Oncology, 2020 p16INK4a (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16INK4a in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes.
Narmen Azazmeh, Ittai Ben-Porath
doaj +1 more source
Cell Death and Disease, 2018 Tumor-associated macrophages (TAMs) are a major component of tumor microenvironment (TME) and play pivotal roles in the progression of hepatocellular carcinoma (HCC).
Yang Yang +7 more
semanticscholar +1 more source
WNT Signaling in Tumors: The Way to Evade Drugs and Immunity
Frontiers in Immunology, 2019 WNT/β-catenin signaling is involved in many physiological processes. Its implication in embryonic development, cell migration, and polarization has been shown.
E. Martín-Orozco +3 more
semanticscholar +1 more source
Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. [PDF]
, 1990 Brian J. Gavin +2 more
openalex +1 more source
Self-organization of a human organizer by combined WNT and NODAL signalling
Nature, 2018 In amniotes, the development of the primitive streak and its accompanying ‘organizer’ define the first stages of gastrulation. Although these structures have been characterized in detail in model organisms, the human primitive streak and organizer remain
I. Martyn +4 more
semanticscholar +1 more source
Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line. [PDF]
, 1992 John O. Mason +2 more
openalex +1 more source
Wnt Signaling Deregulation in the Aging and Alzheimer’s Brain
Frontiers in Cellular Neuroscience, 2019 Growing evidence suggests that synaptic signaling is compromised in the aging brain and in Alzheimer’s disease (AD), contributing to synaptic decline.
E. Palomer, Johanna Buechler, P. Salinas
semanticscholar +1 more source
Clinical Pediatric Endocrinology, 2010 Wnt signaling is involved not only in embryonic development but also in maintenance of homeostasis in postnatal tissues. Multiple lines of evidence have increased understanding of the roles of Wnt signaling in bone since mutations in the LRP5 gene were identified in human bone diseases.
Toshimi Michigami +2 more
openaire +4 more sources
Wnt Signaling in Ovarian Cancer Stemness, EMT, and Therapy Resistance
Journal of Clinical Medicine, 2019 Ovarian cancers represent the deadliest among gynecologic malignancies and are characterized by a hierarchical structure with cancer stem cells (CSCs) endowed with self-renewal and the capacity to differentiate. The Wnt/β-catenin signaling pathway, known
Miriam Teeuwssen, R. Fodde
semanticscholar +1 more source