Results 111 to 120 of about 459,861 (330)

Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo [PDF]

, 2006
The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus.
Callan, Margaret F C, Freeman, Tom, Hasegawa, Hitoshi, Herbert, Mark, McMichael, Andrew J, Willinger, Tim   +5 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

RNA干扰pygo2基因对人脑胶质母细胞瘤U251生物学行为及wnt通路的影响

Zhongguo shiyan zhenduanxue, 2015
目的研究pygo2在胶质瘤细胞系U251中的表达、功能及作用机制。方法利用反义pygo2转染U251,下调pygo2的表达,应用流式细胞术和MTT法,评价细胞生长、增殖、凋亡及周期变化;细胞克隆形成试验和transwell侵袭试验分析细胞的克隆形成能力和侵袭能力,采用Western印迹法检测通路蛋白的表达变化。结果转染反义pygo2后,pygo2表达降低,MTT结果显示转染反义pygo2后细胞生长受到抑制且凋亡细胞增加;流式细胞术提示G1期到S期阻滞,细胞克隆形成能力下降,侵袭能力均受到抑制 ...
傅建华, 王海东, 徐伟伟, 周孟, 王世勇   +4 more
doaj  

Hyperin Controls the Development and Therapy of Gastric Cancer via Regulating Wnt/β-Catenin Signaling

Cancer Management and Research, 2020
Mao-Hua Ping Department of Rehabilitation Medicine, Hanyang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei Province 430050, People ’s Republic of ChinaCorrespondence: Mao-Hua PingDepartment of Rehabilitation ...
Ping MH
doaj  

β-Catenin inhibition shapes tumor immunity and synergizes with immunotherapy in colorectal cancer

OncoImmunology, 2020
In colorectal cancer, Wnt/β-catenin signaling is often aberrantly activated and associated with a T-cell-excluded phenotype which is a major obstacle for many immunotherapies.
Caihong Wang, Jingjing Yan, Pan Yin, Liming Gui, Lu Ji, Bin Ma, Wei-Qiang Gao   +6 more
doaj   +1 more source

Approaches for Regenerative Healing of Cutaneous Wound with an Emphasis on Strategies Activating the Wnt/β-Catenin Pathway

, 2021
Sehee Choi, Minguen Yoon, Kang‐Yell Choi   +2 more
openalex   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Mechanical oscillations orchestrate axial patterning through Wnt activation in Hydra

, 2021
Jaroslav Ferenc, Panagiotis Papasaikas, Jacqueline Ferralli, Yukio Nakamura, Sébastien A. Smallwood, Charisios D. Tsiairis   +5 more
openalex   +1 more source

ACY1 Downregulation Enhances the Radiosensitivity of Cetuximab-Resistant Colorectal Cancer by Inactivating the Wnt/β-Catenin Signaling Pathway [PDF]

, 2022
Wulin Shan, Chunyang Dai, Huanhuan Zhang, Dan Han, Qiyi Yi, Bairong Xia   +5 more
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source