Results 1 to 10 of about 259,205 (374)

Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions Using NanoBit/BRET [PDF]

Cells
Upon engagement of one of the nineteen secreted Wnt signaling proteins with one of the ten Frizzled transmembrane Wnt receptors (FZD1–10), a wide variety of cellular Wnt signaling responses can be elicited, the selectivity of which depends on the ...
Janine Wesslowski, Sadia Safi, Michelle Rottmann, Melanie Rothley, Gary Davidson   +4 more
doaj   +2 more sources

Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling [PDF]

eLife, 2015
Wnt signaling is essential for tissue homeostasis and its dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), which belong to the G-protein coupled receptor superfamily.
Nicolas Aznar, Krishna K Midde, Ying Dunkel, Inmaculada Lopez-Sanchez, Yelena Pavlova, Arthur Marivin, Jorge Barbazán, Fiona Murray, Ulrich Nitsche, Klaus-Peter Janssen, Karl Willert, Ajay Goel, Miguel Abal, Mikel Garcia-Marcos, Pradipta Ghosh   +14 more
doaj   +7 more sources

Mathematical and Statistical Techniques for Systems Medicine: The Wnt Signaling Pathway as a Case Study [PDF]

arXiv, 2015
The last decade has seen an explosion in models that describe phenomena in systems medicine. Such models are especially useful for studying signaling pathways, such as the Wnt pathway. In this chapter we use the Wnt pathway to showcase current mathematical and statistical techniques that enable modelers to gain insight into (models of) gene regulation,
A Gelman, A Saltelli, AC Babtie, AG Fletcher, AL MacLean, AL MacLean, AR Hernández, B Alberts, B Carlin, B Lloyd-Lewis, BR Henderson, CW Gardiner, CW Tan, CW Tan, CY Logan, D Brewer, D Cox, D Kim, E Feliu, E Lee, ER Barry, F Cong, G Craciun, G Craciun, G Craciun, GR Mirams, H Clevers, H Kitano, HA Harrington, I Ramis-Conde, IMM Leeuwen van, J Franca-Koh, J Heuberger, J Jost, J Liepe, J Liepe, J Neumann von, J Stark, J Stelling, J. Kevorkian, K Itoh, KH Cho, L Goentoro, L Vermeulen, M Basan, M Beguerisse-Díaz, M Feinberg, M Feinberg, M Kuhl, M Secrier, M Sunnåker, N Blüthgen, N Gershenfeld, N Gilbert, N Wiechens, O Ratmann, P Buske, P Glendinning, P Kirk, P Polakis, PJ Murray, PJ Murray, R Habas, R Krüger, RN Gutenkunst, S Wolfram, T Reya, T Toni, VSW Li, X Varelas, Y Kogan, Y Schmitz, Y Schmitz, Y Zhou   +73 more
arxiv   +3 more sources

β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation. [PDF]

PLoS ONE, 2014
β-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and β-Catenin ...
Katharina Seitz, Verena Dürsch, Jakub Harnoš, Vitezslav Bryja, Marc Gentzel, Alexandra Schambony   +5 more
doaj   +1 more source

The role of Sfrp and DKK proteins in cardiomyocyte development

Physiological Reports, 2021
In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β‐catenin signaling pathways and Wnt ...
Ying‐Chang Hsueh, Conrad P. Hodgkinson, Jose A. Gomez   +2 more
doaj   +1 more source

Role of Wnt Signaling in Mouse Fetal Skin Wound Healing

Biomedicines, 2022
Wnt proteins secrete glycoproteins that are involved in various cellular processes to maintain homeostasis during development and adulthood. However, the expression and role of Wnt in wound healing have not been fully documented.
Kento Takaya, Ayano Sunohara, Noriko Aramaki-Hattori, Shigeki Sakai, Keisuke Okabe, Hideko Kanazawa, Toru Asou, Kazuo Kishi   +7 more
doaj   +1 more source

A mathematical modelling portrait of Wnt signalling in early vertebrate embryogenesis [PDF]

Journal of Theoretical Biology 551-552 (2022) 111239, 2022
There are two phases of Wnt signalling in early vertebrate embryogenesis: very early, maternal Wnt signalling promotes dorsal development, and slightly later, zygotic Wnt signalling promotes ventral and lateral mesoderm induction. However, recent molecular biology analysis has revealed more complexity among the direct Wnt target genes, with at least ...
arxiv   +1 more source

Targets of Wnt/ß-catenin transcription in penile carcinoma. [PDF]

PLoS ONE, 2015
Penile squamous cell carcinoma (PeCa) is a rare malignancy and little is known regarding the molecular mechanisms involved in carcinogenesis of PeCa. The Wnt signaling pathway, with the transcription activator ß-catenin as a major transducer, is a key ...
Manit Arya, Christopher Thrasivoulou, Rui Henrique, Michael Millar, Ruth Hamblin, Reena Davda, Kristina Aare, John R Masters, Calum Thomson, Asif Muneer, Hitendra R H Patel, Aamir Ahmed   +11 more
doaj   +1 more source

Whole Genome Level Analysis of the Wnt and DIX Gene Families in Mice and Their Coordination Relationship in Regulating Cardiac Hypertrophy

Frontiers in Genetics, 2021
The Wnt signaling pathway is an evolutionarily conserved signaling pathway that plays essential roles in embryonic development, organogenesis, and many other biological activities.
Zhongchao Gai, Yujiao Wang, Lu Tian, Guoli Gong, Jieqiong Zhao   +4 more
doaj   +1 more source

Wnt signalling pathway parameters for mammalian cells. [PDF]

PLoS ONE, 2012
Wnt/β-catenin signalling regulates cell fate, survival, proliferation and differentiation at many stages of mammalian development and pathology. Mutations of two key proteins in the pathway, APC and β-catenin, have been implicated in a range of cancers ...
Chin Wee Tan, Bruce S Gardiner, Yumiko Hirokawa, Meredith J Layton, David W Smith, Antony W Burgess   +5 more
doaj   +1 more source