Results 1 to 10 of about 5,816,927 (247)
The role of Evi/Wntless in exporting Wnt proteins.
Development, 2023 Intercellular communication by Wnt proteins governs many essential processes during development, tissue homeostasis and disease in all metazoans.
Wolf L, Boutros M.
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Wnt proteins can direct planar cell polarity in vertebrate ectoderm. [PDF]
Elife, 2016 The coordinated orientation of cells across the tissue plane, known as planar cell polarity (PCP), is manifested by the segregation of core PCP proteins to different sides of the cell.
Chu CW, Sokol SY.
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Cold Spring Harb Perspect Biol, 2012 Wnt proteins comprise a major family of signaling molecules that orchestrate and influence a myriad of cell biological and developmental processes. Although our understanding of the role of Wnt signaling in regulating development and affecting disease ...
Willert K, Nusse R.
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Bioinformatic Analysis of WNT Family Proteins [PDF]
Bioinformatics and Biology InsightsWNT proteins constitute a highly conserved family of signaling molecules that play an important role in regulating embryonic development and maintaining adult tissue homeostasis.
Konstantin Midlovets +2 more
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Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Bone ResearchWnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways, which control various biological processes throughout embryonic development and adult life ...
Lifang Hu +3 more
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Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Signal Transduction and Targeted Therapy, 2022 The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer
Jiaqi Liu +8 more
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Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions Using NanoBit/BRET [PDF]
CellsUpon engagement of one of the nineteen secreted Wnt signaling proteins with one of the ten Frizzled transmembrane Wnt receptors (FZD1–10), a wide variety of cellular Wnt signaling responses can be elicited, the selectivity of which depends on the ...
Janine Wesslowski +4 more
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Probing Wnt pathway and functional signal in equine melanocytic neoplasms through quantitative proteomics and immunohistochemistry [PDF]
BMC Veterinary ResearchBackground Equine melanocytic neoplasm (EMN) is a skin tumor commonly observed in grey horses. Limited research has yet to investigate proteomic profiles of EMN, particularly in the early stages and their expression patterns. This study, therefore, aimed
Parichart Tesena +9 more
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LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
Frontiers in Cell and Developmental Biology, 2021 The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic development, injury repair and the pathogenesis of human diseases.
Qian Ren +3 more
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Frontiers in Pharmacology, 2021 The Wnt/β-catenin signaling pathway plays important roles in embryonic development and tissue homeostasis. Wnt signaling is induced, and β-catenin is activated, associated with the development and progression of renal fibrosis. Wnt/β-catenin controls the
Shan-Shan Li +8 more
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