Results 1 to 10 of about 176,136 (293)
Cold Spring Harb Perspect Biol, 2012 Wnt proteins comprise a major family of signaling molecules that orchestrate and influence a myriad of cell biological and developmental processes. Although our understanding of the role of Wnt signaling in regulating development and affecting disease, such as cancer, has been ever increasing, the study of the Wnt proteins themselves has been ...
Willert K, Nusse R.
europepmc +4 more sources
Wnt proteins as modulators of synaptic plasticity.
Curr Opin Neurobiol, 2018 Dynamic changes in the structure and function of synapses in response to the environment, termed synaptic plasticity, are the cellular basis of learning and memory. At excitatory synapses, activation of NMDA receptors by glutamate leads to calcium influx triggering intracellular pathways that promote the trafficking of AMPA receptors to the post ...
McLeod F, Salinas PC.
europepmc +5 more sources
Positive cooperativity in synergistic activation of Wnt proteins. [PDF]
Mol Biol RepAbstract Background Wnt proteins are crucial for embryonic development, stem cell growth, and tissue regeneration. Wnt signaling pathway is activated when Wnt proteins bind to cell membrane receptors. Methods and results We employed a luciferase reporter assay in HEK293STF
Bonnet C, Han CS, Deng SX, Zheng JJ.
europepmc +5 more sources
Bioinformatic Analysis of WNT Family Proteins
Bioinformatics and Biology InsightsWNT proteins constitute a highly conserved family of signaling molecules that play an important role in regulating embryonic development and maintaining adult tissue homeostasis.
Konstantin Midlovets +2 more
doaj +2 more sources
Genome-wide identification and expression analysis of Wnt gene family in the forest musk deer (Moschus berezovskii) under musk secretion stage [PDF]
BMC GenomicsThe Wnt signaling pathway is ubiquitous in animals, playing a crucial role in embryonic development and adult tissue homeostasis in multicellular organisms.
Yu-JiaWei Gu +6 more
doaj +2 more sources
β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation. [PDF]
PLoS ONE, 2014 β-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and β-Catenin ...
Katharina Seitz +5 more
doaj +1 more source
The role of Sfrp and DKK proteins in cardiomyocyte development
Physiological Reports, 2021 In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β‐catenin signaling pathways and Wnt ...
Ying‐Chang Hsueh +2 more
doaj +1 more source
Targets of Wnt/ß-catenin transcription in penile carcinoma. [PDF]
PLoS ONE, 2015 Penile squamous cell carcinoma (PeCa) is a rare malignancy and little is known regarding the molecular mechanisms involved in carcinogenesis of PeCa. The Wnt signaling pathway, with the transcription activator ß-catenin as a major transducer, is a key ...
Manit Arya +11 more
doaj +1 more source
Role of Wnt Signaling in Mouse Fetal Skin Wound Healing
Biomedicines, 2022 Wnt proteins secrete glycoproteins that are involved in various cellular processes to maintain homeostasis during development and adulthood. However, the expression and role of Wnt in wound healing have not been fully documented.
Kento Takaya +7 more
doaj +1 more source