Results 1 to 10 of about 6,673,592 (274)
Cold Spring Harb Perspect Biol, 2012 Wnt proteins comprise a major family of signaling molecules that orchestrate and influence a myriad of cell biological and developmental processes. Although our understanding of the role of Wnt signaling in regulating development and affecting disease, such as cancer, has been ever increasing, the study of the Wnt proteins themselves has been ...
Willert K, Nusse R.
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Wnt proteins as modulators of synaptic plasticity.
Curr Opin Neurobiol, 2018 Highlights • LTP induction promotes the localization of Wnt7a/b protein at dendritic spines.• Wnt-Frizzled signaling is required for NMDA receptor-dependent LTP.• Wnt7a specifically regulates rapid AMPA receptor trafficking at the synapse.• Defects in ...
McLeod F, Salinas PC.
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The role of Evi/Wntless in exporting Wnt proteins.
Development, 2023 Intercellular communication by Wnt proteins governs many essential processes during development, tissue homeostasis and disease in all metazoans.
Wolf L, Boutros M.
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Wnt proteins can direct planar cell polarity in vertebrate ectoderm. [PDF]
Elife, 2016 The coordinated orientation of cells across the tissue plane, known as planar cell polarity (PCP), is manifested by the segregation of core PCP proteins to different sides of the cell.
Chu CW, Sokol SY.
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Immobilized WNT Proteins Act as a Stem Cell Niche for Tissue Engineering. [PDF]
Stem Cell Reports, 2016 Summary The timing, location, and level of WNT signaling are highly regulated during embryonic development and for the maintenance of adult tissues. Consequently the ability to provide a defined and directed source of WNT proteins is crucial to fully ...
Lowndes M +4 more
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Wnt proteins synergize to activate β-catenin signaling [PDF]
Journal of Cell Science, 2017 ABSTRACT Wnt ligands are involved in diverse signaling pathways that are active during development, maintenance of tissue homeostasis and in various disease states. While signaling regulated by individual Wnts has been extensively studied, Wnts are rarely expressed alone, and the consequences of Wnt gene co-expression are not well ...
Anshu Alok +7 more
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Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Bone ResearchWnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways, which control various biological processes throughout embryonic development and adult life ...
Lifang Hu +3 more
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Genes and Diseases, 2023 Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing
Kevin Qin +20 more
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Positive cooperativity in synergistic activation of Wnt proteins. [PDF]
Mol Biol RepAbstract Background Wnt proteins are crucial for embryonic development, stem cell growth, and tissue regeneration. Wnt signaling pathway is activated when Wnt proteins bind to cell membrane receptors. Methods and results We employed a luciferase reporter assay in HEK293STF
Bonnet C, Han CS, Deng SX, Zheng JJ.
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Bioinformatic Analysis of WNT Family Proteins
Bioinformatics and Biology InsightsWNT proteins constitute a highly conserved family of signaling molecules that play an important role in regulating embryonic development and maintaining adult tissue homeostasis.
Konstantin Midlovets +2 more
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