Insight into the WNT system and its drug related response
Reumatismo, 2013 The WNT signalling pathway is a complex system for transferring information for DNA expression from the cell surface receptors to cytoplasm and then to the nucleus.
S. Tamanini +5 more
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Role of morphogenic proteins of the WNT signaling pathway in coronary artery disease
Медицинская иммунология, 2023 In recent years, researchers’ attention has been directed to the WNT signaling pathway study, which regulates embryogenesis processes and is involved in pathological condition development.
I. A. Snimshchikova, M. O. Plotnikova
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Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart
The Scientific World Journal, 2007 Wnts are a family of secreted signaling proteins that are encoded by 19 distinct genes in the vertebrate genome. These molecules initiate several signal transduction pathways: the canonical Wnt, Wnt/Ca2+, and Wnt/planar cell polarity pathways.
Leonard M. Eisenberg, Carol A. Eisenberg
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A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion
Cell Reports, 2019 Summary: Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain uncharacterized ...
Nanna Torpe +6 more
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The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling
Neurobiology of Disease, 2007 Endosomal acidification and transport are essential functions in signal transduction. Recent data suggest that Wnt signaling requires intact endosomal transport machinery but the effects of endosomal acidification on Wnt signal transduction have not been
Ana George +3 more
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Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities. [PDF]
PLoS ONE, 2013 Functional and mechanistic studies of Wnt signaling have been severely hindered by the inaccessibility of bioactive proteins. To overcome this long-standing barrier, we engineered and characterized a panel of Chinese hamster ovary (CHO) cell lines with ...
Jennifer L Green +6 more
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Targeted protein degradation systems to enhance Wnt signaling
eLife, 2023 Abstract Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. Human hepatic lectin, asialoglycoprotein receptor (ASGR) is selectively expressed on hepatocytes. We have previously engineered an anti-ASGR1 antibody-mutant RSPO2 (RSPO2RA) fusion protein (called SWEETSTM) to drive tissue ...
Heekyung Jung +12 more
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Biochemical characterization of Wnt-Frizzled interactions using a soluble, biologically active vertebrate Wnt protein [PDF]
Proceedings of the National Academy of Sciences, 1999 Biochemical studies of Wnt signaling have been hampered by difficulties in obtaining large quantities of soluble, biologically active Wnt proteins. In this paper, we report the production in Drosophila S2 cells of biologically active Xenopus Wnt8 (XWnt8).
J C, Hsieh +3 more
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Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL
eLifeFrizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive.
Dong Luo +6 more
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Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling. [PDF]
PLoS ONE, 2011 Canonical Wnt signaling is controlled intracellularly by the level of β-catenin protein, which is dependent on Axin scaffolding of a complex that phosphorylates β-catenin to target it for ubiquitylation and proteasomal degradation.
Marinella G Callow +14 more
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