Progress of Wnt Signaling Pathway in Osteoporosis
Biomolecules, 2023 Osteoporosis, one of the serious health diseases, involves bone mass loss, bone density diminishing, and degeneration of bone microstructure, which is accompanied by a tendency toward bone fragility and a predisposition to fracture. More than 200 million
Yongguang Gao +3 more
semanticscholar +1 more source
Wnt Signaling Translocates Lys48-Linked Polyubiquitinated Proteins to the Lysosomal Pathway
Cell Reports, 2015 Cellular proteins are degraded in either proteasomes or lysosomes depending on the types of ubiquitin chains that covalently modify them. It is not known whether the choice between these two pathways is physiologically regulated.
Hyunjoon Kim +4 more
doaj +1 more source
IGFBP-3 inhibits Wnt signaling in metastatic melanoma cells. [PDF]
, 2016 In previous works, we have shown that insulin-like growth factor-binding protein-3 (IGFBP-3), a tissue and circulating protein able to bind to IGFs, decreases drastically in the blood serum of patients with diffuse metastatic melanoma.
Londei, Paola +7 more
core +1 more source
Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis. [PDF]
, 2019 Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic ...
Hao, Hongyan +4 more
core +2 more sources
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. [PDF]
PLoS Biology, 2006 The Wnts comprise a large class of secreted proteins that control essential developmental processes such as embryonic patterning, cell growth, migration, and differentiation.
Amanda J Mikels, Roel Nusse
doaj +1 more source
Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]
, 2002 Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
core +2 more sources
Wnt signaling during tooth replacement in zebrafish (Danio rerio) : pitfalls and perspectives [PDF]
, 2014 The canonical (13-catenin dependent) Wnt signaling pathway has emerged as a likely candidate for regulating tooth replacement in continuously renewing dentitions.
Elderweirdt, Fien +2 more
core +6 more sources
Cell Communication and Signaling, 2005 Background Secreted Frizzled related proteins (SFRPs) are extracellular regulators of Wnt signaling. These proteins contain an N-terminal cysteine rich domain (CRD) highly similar to the CRDs of the Frizzled family of seven-transmembrane proteins that ...
Medina Araceli +3 more
doaj +1 more source
Functional role of the Frizzled linker domain in the Wnt signaling pathway
Communications Biology, 2022 The linker domain of Frizzled receptors has a varying effect on the functional levels of canonical and non-canonical Wnt signaling, with FZD chimeras influencing the binding of Wnt proteins and the recruitment of proteins regulating downstream signaling.
Seung-Bum Ko +7 more
doaj +1 more source
A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin. [PDF]
, 2017 Cellular proliferation is antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the noncanonical Wnt ...
Aznar, Nicolas +5 more
core +2 more sources