Results 21 to 30 of about 259,205 (374)
Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion [PDF]
Developmental Cell, 2006 The secretion and extracellular transport of Wnt protein are thought to be well-regulated processes. Wnt is known to be acylated with palmitic acid at a conserved cysteine residue (Cys77 in murine Wnt-3a), and this residue appears to be required for the control of extracellular transport. Here, we show that murine Wnt-3a is also acylated at a conserved
Naoto Ueno +8 more
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Functional role of the Frizzled linker domain in the Wnt signaling pathway
Communications Biology, 2022 The linker domain of Frizzled receptors has a varying effect on the functional levels of canonical and non-canonical Wnt signaling, with FZD chimeras influencing the binding of Wnt proteins and the recruitment of proteins regulating downstream signaling.
Seung-Bum Ko +7 more
doaj +1 more source
Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]
, 2012 Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Capovilla, Simon +8 more
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Activity of Wnt-1 as a transmembrane protein. [PDF]
Genes & Development, 1993 The product of the Wnt-1 proto-oncogene is a cysteine-rich glycoprotein that plays a crucial role in the development of the vertebrate central nervous system. Wnt-1 protein is secreted but remains associated with the cell surface and extracellular matrix.
Jan Kitajewski +2 more
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Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. [PDF]
PLoS Biology, 2006 The Wnts comprise a large class of secreted proteins that control essential developmental processes such as embryonic patterning, cell growth, migration, and differentiation.
Amanda J Mikels, Roel Nusse
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Spreading around a Wnt protein [PDF]
Journal of Cell Biology, 2013 ![Figure][1] In a fly lacking Trol, arrows and arrowheads mark the extra boutons in a neuromuscular junction stained for pre- (purple) and postsynaptic (green) markers. Aproteoglycan helps disperse Wnt proteins during development of the neuromuscular junction, [Kamimura et al.][2 ...
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Cell Communication and Signaling, 2005 Background Secreted Frizzled related proteins (SFRPs) are extracellular regulators of Wnt signaling. These proteins contain an N-terminal cysteine rich domain (CRD) highly similar to the CRDs of the Frizzled family of seven-transmembrane proteins that ...
Medina Araceli +3 more
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Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]
, 2002 Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
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A Role for WNT Proteins in Induction of Dermomyotome
Developmental Biology, 1997 Dorsoventral patterning of somites into sclerotome and dermomyotome involves antagonistic actions of ventralizing and dorsalizing signals originating from tissues surrounding the somites. The notochord and the floor plate of the neural tube provide a ventralizing signal(s) directing sclerotome development, whereas the surface ectoderm and dorsal neural
Chen-Ming Fan +2 more
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PLoS ONE, 2009 BackgroundMutation of Wnt signal antagonists Apc or Axin activates beta-catenin signaling in many cancers including the majority of human colorectal adenocarcinomas.
Jianhui Guo +13 more
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