Results 101 to 110 of about 5,118,873 (324)
Wnt Signaling Deregulation in the Aging and Alzheimer’s Brain
Frontiers in Cellular Neuroscience, 2019 Growing evidence suggests that synaptic signaling is compromised in the aging brain and in Alzheimer’s disease (AD), contributing to synaptic decline.
E. Palomer, Johanna Buechler, P. Salinas
semanticscholar +1 more source
The Wnt signalling pathway [PDF]
Journal of Cell Science, 2002 Recent advances in the field require an update of our Wnt pathway scheme ( [Hulsken and Behrens, 2000][1]). Intracellular signaling of the Wnt pathway diversifies into at least three branches: (1) the β-catenin pathway (canonical Wnt pathway, blue), which activates target genes in the nucleus ...
Joerg, Huelsken, Juergen, Behrens
openaire +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Genes and DiseasesThe evolutionarily conserved Wnt signaling pathway plays a central role in development and adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling molecules that activate the canonical (β-catenin dependent) and non ...
Michael Yu +18 more
doaj +1 more source
Aberrant WNT/CTNNB1 Signaling as a Therapeutic Target in Human Breast Cancer: Weighing the Evidence
Frontiers in Cell and Developmental Biology, 2020 WNT signaling is crucial for tissue morphogenesis during development in all multicellular animals. After birth, WNT/CTNNB1 responsive stem cells are responsible for tissue homeostasis in various organs and hyperactive WNT/CTNNB1 signaling is observed in ...
Emma H. van Schie, Renée van Amerongen
doaj +1 more source
High MYC mRNA expression is more clinically relevant than MYC DNA amplification in triple-negative breast cancer [PDF]
, 2019 DNA abnormalities are used in inclusion criteria of clinical trials for treatments with specific targeted molecules. MYC is one of the most powerful oncogenes and is known to be associated with triple-negative breast cancer (TNBC).
Dasgupta, Subhamoy +6 more
core +2 more sources
Wnt signaling in atherosclerosis [PDF]
European Journal of Pharmacology, 2015 Atherosclerosis is a disease of the vascular wall that forms the basis for a large spectrum of pathologies of various organs and tissues. Although massive research efforts in the last decades have yielded valuable information about its underlying molecular mechanisms, this has not led to a translation into effective therapeutic interventions that can ...
Blankesteijn, W. Matthijs +1 more
openaire +3 more sources
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Canonical Wnt signaling activity in early stages of chick lung development.
PLoS ONE, 2014 Wnt signaling pathway is an essential player during vertebrate embryonic development which has been associated with several developmental processes such as gastrulation, body axis formation and morphogenesis of numerous organs, namely the lung.
Rute Silva Moura +3 more
doaj +1 more source
Stem Cell Reports, 2016 Wnt signaling is a key regulator of vertebrate heart development; however, specific roles for human cardiomyocyte development remain uncertain. Here we use human embryonic stem cells (hESCs) to analyze systematically in human cardiomyocyte development ...
Silvia Mazzotta +5 more
doaj +1 more source