Results 281 to 290 of about 5,118,873 (324)

Correction: Structural insights into the Caprin-2 HR1 domain in canonical Wnt signaling. [PDF]

J Biol Chem
Su C, Zhong Y, Zhou Z, Li Y, Jia Y, Xie S, Zhao J, Miao H, Luo H, Li Z, Shi Z, Li L, Song X.   +12 more
europepmc   +1 more source

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source

LOXL2⁺ cancer-associated fibroblasts shape WNT signaling to drive chemoresistance and poor outcomes in colorectal cancer: Insights from multi-omics and epidemiological analyses. [PDF]

Neoplasia
Xu C, Li T, Zhang L, Zhang Q, Cai S, Fu Q, Zhang S.   +6 more
europepmc   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

ZIC5, a survival biomarker, facilitates tumor progression and stemness in colon cancer via the activation of the Wnt signaling pathway. [PDF]

Sci Rep
Li X, Zhao C, Mu M, Yuan H, Chen G, Chen S, Huo X, Sun X, Yu J.   +8 more
europepmc   +1 more source

Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design

Advanced Science, EarlyView.
Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao, Cheng Huang, Jiaxuan Deng, Lei Wang, Baojun Wang   +4 more
wiley   +1 more source

Wnt target IQGAP3 promotes Wnt signaling via disrupting Axin1-CK1α interaction. [PDF]

Oncogene
Rahmat MB, Hussain A, Teh YX, Dutta B, Pundrik S, Kappei D, Ito Y.   +6 more
europepmc   +1 more source

Structural Features of Glypicans and their Impact on Wnt Signaling in Cancer. [PDF]

Proteoglycan Res
Tsao HE, Ho M.
europepmc   +1 more source

An Integrated Canonical and Non-Canonical Wnt Signaling Network Controls Early Anterior-Posterior Axis Formation in Sea Urchin Embryos. [PDF]

J Dev Biol
Fenner JL, Wang B, Ka C, Gautam S, Range RC.   +4 more
europepmc   +1 more source