Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]
, 2012 Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson +79 more
core +1 more source
Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data. [PDF]
PLoS ONE, 2015 WNT signaling is a complex process comprising multiple pathways: the canonical β-catenin-dependent pathway and several alternative non-canonical pathways that act in a β-catenin-independent manner.
Michaela Bayerlová +5 more
doaj +1 more source
A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus [PDF]
, 2019 During vertebrate embryogenesis, the cranial neural crest (CNC) forms at the neural plate border and subsequently migrates and differentiates into many types of cells.
Duncan, Melinda K. +7 more
core +1 more source
Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis
Frontiers in Cell and Developmental Biology, 2021 Mesenchymal stem cells (MSCs) give rise to adipocytes, osteocytes, and chondrocytes and reside in various tissues, including bone marrow and adipose tissue.
Twan J. J. de Winter +2 more
doaj +1 more source
Wnt signaling during tooth replacement in zebrafish (Danio rerio) : pitfalls and perspectives [PDF]
, 2014 The canonical (13-catenin dependent) Wnt signaling pathway has emerged as a likely candidate for regulating tooth replacement in continuously renewing dentitions.
Elderweirdt, Fien +2 more
core +3 more sources
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
Nature Communications, 2016 Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous ...
Patrizia Cammareri +28 more
doaj +1 more source
Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural Stem cell specification into oligodendrocytes and glutamatergic neurons [PDF]
, 2014 In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS.
Azim, Kasum +8 more
core +1 more source
Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction
Cell Reports, 2019 Summary: Wnt signaling affects fundamental development pathways and, if aberrantly activated, promotes the development of cancers. Wnt signaling is modulated by different factors, but whether the mitochondrial energetic state affects Wnt signaling is ...
Roberto Costa +19 more
doaj +1 more source
Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected [PDF]
, 2004 Polycystin-1, the polycystic kidney disease 1 gene product, has been implicated in several signaling complexes that are known to regulate essential cellular functions. We investigated the role of polycystin-1 in Wnt signaling and activator protein-1 (
Arnould +37 more
core +3 more sources
Oncogene, 2016 Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components
T Zhan, N Rindtorff, M Boutros
openaire +2 more sources