Results 51 to 60 of about 5,118,873 (324)

Wnt signaling potentiates nevogenesis [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Human benign nevi (moles) are clonal neoplasms that rarely progress to melanoma because their cells (melanocytes) are arrested in a viable but nonproliferating state (senescence). However, at low frequency, nevus melanocytes do progress to melanoma.
Pawlikowski, J.S., McBryan, T., van Tuyn, J., Drotar, M.E., Hewitt, R.N., Maier, A.B., King, A., Blyth, K., Wu, H., Adams, P.D.   +9 more
openaire   +4 more sources

High throughput genomic screen identifies multiple factors that promote cooperative Wnt signaling. [PDF]

PLoS ONE, 2013
Previous studies have demonstrated that certain Wnt ligands can promote high levels of cooperative signaling in a cell type specific manner. To explore the underlying mechanism of this cooperative Wnt signaling, we performed a high-throughput screen of ...
Mayumi F Miller, Ethan David Cohen, Julie E Baggs, John B Hogenesch, Edward E Morrisey   +4 more
doaj   +1 more source

β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation. [PDF]

PLoS ONE, 2014
β-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and β-Catenin ...
Katharina Seitz, Verena Dürsch, Jakub Harnoš, Vitezslav Bryja, Marc Gentzel, Alexandra Schambony   +5 more
doaj   +1 more source

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

Cell Death and Differentiation, 2022
The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance ...
Yue Wang, Lixin Zheng, Wenjing Shang, Zongchen Yang, Tongyu Li, Fen Liu, Weimin Shao, Lin Lv, Li Chai, L. Qu, Qing Xu, J. Du, Xiuming Liang, Jiping Zeng, J. Jia   +14 more
semanticscholar   +1 more source

Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]

, 2012
Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Capovilla, Simon, Fernsebner, Katharina, Geissler, Claudia, Jochum, Marianne, Kolben, Thomas, Lechner, Felix, Neth, Peter, Peroebner, Iris, Ruiz-Heinrich, Lourdes   +8 more
core   +2 more sources

Upregulated wnt-11 and mir-21 expression trigger epithelial mesenchymal transition in aggressive prostate cancer cells [PDF]

, 2020
Prostate cancer (PCa) is the second-leading cause of cancer-related death among men. microRNAs have been identified as having potential roles in tumorigenesis.
Arisan, E.D., Arisan, E.D., Freitas, I.L., Freitas, I.L., Keskin, B., Keskin, B., Kothari, A., Kothari, A., Radzali, S., Radzali, S., Rencuzogullari, O., Rencuzogullari, O., Uysal-Onganer, P., Uysal-Onganer, P., Warford, A., Warford, A.   +15 more
core   +1 more source

Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers

International Journal of Molecular Sciences, 2020
The Wnt signaling pathway plays important roles in embryonic development, homeostatic processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β-catenin binding of Wnt target genes.
Hong-Beom Park, Ju-Won Kim, K. Baek
semanticscholar   +1 more source

Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene [PDF]

, 2018
Indexación: Scopus.Synaptic abnormalities have been described in individuals with autism spectrum disorders (ASD). The cell-adhesion molecule Neuroligin-3 (Nlgn3) has an essential role in the function and maturation of synapses and NLGN3 ASD-associated ...
Andrade, V.M., Avila, M.E., Caracci, M.O., De Ferrari, G.V., Medina, M.A., Opazo, C., Reyes, A.E., Ugarte, G.D., Vargas, M.F., Verdugo, D.A.   +9 more
core   +1 more source

Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy

Journal of Hematology & Oncology
The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development, tissue homeostasis, and cell proliferation.
Pan Song, Zirui Gao, Yige Bao, Li Chen, Yuhe Huang, Yanyan Liu, Qiang Dong, Xiawei Wei   +7 more
semanticscholar   +1 more source

Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling

Cell Reports, 2018
Summary: Wnt/β-catenin signaling is necessary for lymphatic vascular development. Oscillatory shear stress (OSS) enhances Wnt/β-catenin signaling in cultured lymphatic endothelial cells (LECs) to induce expression of the lymphedema-associated ...
Boksik Cha, Xin Geng, Md. Riaj Mahamud, Jenny Y. Zhang, Lijuan Chen, Wantae Kim, Eek-hoon Jho, Yeunhee Kim, Dongwon Choi, J. Brandon Dixon, Hong Chen, Young-Kwon Hong, Lorin Olson, Tae Hoon Kim, Bradley J. Merrill, Michael J. Davis, R. Sathish Srinivasan   +16 more
doaj   +1 more source