Results 61 to 70 of about 5,118,873 (324)

Dynamic alterations in gene expression after Wnt-mediated induction of avian neural crest [PDF]

, 2005
The Wnt signaling pathway is important in the formation of neural crest cells in many vertebrates, but the downstream targets of neural crest induction by Wnt are largely unknown. Here, we examined quantitative changes in gene expression regulated by Wnt-
Bronner, Marianne E., Taneyhill, Lisa A.
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/β-catenin signaling [PDF]

, 2012
Tissue inhibitor of metalloproteinases 1 (TIMP-1) is a matrix metalloproteinase (MMP)-independent regulator of growth and apoptosis in various cell types.
Avalos, Bartel, Behrens, Brew, C. Ries, Chirco, Clevers, Dasse, Day, Egea, Fata, Goff, Guedez, Guo, Huang, Huang, Ivey, Jho, Jiang, John, Joyce, Jung, K. Kehe, Liu, M. Jochum, MacDonald, Martinez, N. Rieth, P. Neth, Peter, Pittenger, Prockop, Reynolds, S. Zahler, Schiltz, Shtutman, Singer, T. Popp, Takahashi, Taube, V. Egea, Wingfield, Yi   +42 more
core   +1 more source

Wnt signaling in development and tissue homeostasis

Development, 2018
The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis.
Z. Steinhart, S. Angers
semanticscholar   +1 more source

Adipogenesis and WNT signalling [PDF]

Trends in Endocrinology & Metabolism, 2009
An inability of adipose tissue to expand consequent to exhausted capacity to recruit new adipocytes might underlie the association between obesity and insulin resistance. Adipocytes arise from mesenchymal precursors whose commitment and differentiation along the adipocytic lineage is tightly regulated.
Christodoulides, C, Lagathu, C, Sethi, J, Vidal-Puig, A   +3 more
openaire   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Role of the Wnt signaling molecules in the tooth

Japanese Dental Science Review, 2016
Wnt signaling plays a central role in many processes during embryonic development and adult homeostasis. At least 19 types of Wnt ligands, receptors, transducers, transcription factors, and antagonists have been identified in mammals.
Masato Tamura, PhD, DDS, Eiji Nemoto, PhD, DDS   +1 more
doaj   +1 more source

Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts

Frontiers in Cell and Developmental Biology, 2021
Both canonical and non-canonical Wnt signaling pathway alterations have been documented in pulmonary disease pathogenesis and progression; therefore, they can be an attractive target for pharmaceutical management of severe asthma. Wnt/β-catenin signaling
Mahmood Yaseen Hachim, Noha Mousaad Elemam, Rakhee K. Ramakrishnan, Khuloud Bajbouj, Ronald Olivenstein, Ibrahim Yaseen Hachim, Saba Al Heialy, Saba Al Heialy, Qutayba Hamid, Qutayba Hamid, Hauke Busch, Rifat Hamoudi, Rifat Hamoudi   +12 more
doaj   +1 more source

Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome [PDF]

, 2018
Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly ...
Addya, Sankar, Casimiro, Mathew C., Deng, Shengqiong, DiSante, Gabriele, Dong, Lin, Ertel, Adam, Gormley, Michael, Ju, Xiaoming, Li, Qinchuan, Pestell, Richard G., Pestell, Timothy G., Qiao, Jing, Tozeren, Ayden, Wang, Guangxue, Wang, Min, Yu, Zuoren, Zhao, Qian   +16 more
core   +2 more sources

Wnt/β-catenin signaling in cancers and targeted therapies

Signal Transduction and Targeted Therapy, 2021
Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence, advancement of malignant progression ...
F. Yu, Changhao Yu, Feifei Li, Yanqin Zuo, Yitian Wang, L. Yao, Chen-zhou Wu, Chenglin Wang, L. Ye   +8 more
semanticscholar   +1 more source