Results 261 to 270 of about 157,727 (346)

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Partner-sourced haptic feedback rather than environmental inputs drives coordination improvement in human dyadic collaboration. [PDF]

Sci Rep
Liu Y, Leib R, Dudley W, Shafti A, Faisal AA, Franklin DW.   +5 more
europepmc   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Navigating AI feedback in translation training: how text type, proficiency, and attitude shape students' acceptance behaviors. [PDF]

Front Artif Intell
Chen S, Lou J.
europepmc   +1 more source

Evaluating the Utilities of Foundation Models in Single‐Cell Data Analysis

Advanced Science, EarlyView.
This study delivers the first systematic, task‐level evaluation of single‐cell foundation models across eight core analytical tasks. By benchmarking 10 leading models with the scEval framework, it reveals where foundation models truly add value, where task‐specific methods still dominate, and provides concrete, reproducible guidelines to steer the next
Tianyu Liu, Kexing Li, Yuge Wang, Hongyu Li, Hongyu Zhao   +4 more
wiley   +1 more source

Effect of cognitive bias modification training on body image dissatisfaction in adolescents with anorexia nervosa or depression-a pilot feasibility randomized controlled crossover study. [PDF]

Front Psychol
Glombitza E, Cornelissen PL, Tovée MJ, Legenbauer T.   +3 more
europepmc   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Feasibility of virtual reality-based simulation for neonatal resuscitation training: a pilot study at an international site. [PDF]

J Perinatol
Trinh G, Ho T T B, Eickhoff JC, McAdams RM.   +3 more
europepmc   +1 more source

Effects of Bracing Combined With Tele-Rehabilitation-Guided Family Physiotherapeutic Scoliosis-Specific Exercises on Adolescent Idiopathic Scoliosis. [PDF]

Orthop Surg
Chen T, Zhou H, Chen Q, Chen L, Zhang Z, Shu Z, Jiang S, Wang X, Wu A, Huang X.   +9 more
europepmc   +1 more source

APSIC guidelines for environmental hygiene: surface cleaning air and water quality in hospitals: 2025 update. [PDF]

Antimicrob Steward Healthc Epidemiol
Apisarnthanarak A, Ling ML, Jaggi N, Ching P, Liang L, Zong Z.   +5 more
europepmc   +1 more source