Results 131 to 140 of about 2,154,457 (328)

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source

Biomolecular Interaction Prediction: The Era of AI

Advanced Science, EarlyView.
This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley   +1 more source

X-ray crystallographyby E. M. Uygur [PDF]

, 1986
R. Srinivasan
openalex   +1 more source

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review

Advanced Science, EarlyView.
This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu, Jia Yan, Yuyan Zhang, Xiaozhi Ming, Siqi Chen, Zhichao Zou, Nianjie Feng, Jianbo Xiao   +7 more
wiley   +1 more source

X-ray crystallography of FAB fragments of anti-digoxin and anti-arsonate antibodies [PDF]

, 1984
David R. Rose, Gregory A. Petsko, Michael N. Margolies, Jiřı́ Novotný, E Haber, M L Gefter   +5 more
openalex   +1 more source

Inhaling Eugenol Inhibits NAFLD by Activating the Hepatic Ectopic Olfactory Receptor Olfr544 and Modulating the Gut Microbiota

Advanced Science, EarlyView.
Inhalable eugenol (EUG) from clove oil attenuates NAFLD by activating hepatic olfactory receptor Olfr544, triggering cAMP/PKA/CREB signaling to enhance lipolysis/oxidation. EUG concurrently restores gut microbiota, enriching probiotics (L. reuteri XR23/L. johnsonii XR25) and metabolites (IPA/5‐HIAA) that suppress lipogenesis.
Xiao‐Ran Wang, Zhan‐Zhan Li, Shu‐Ding Sun, Ya‐Gang Song, Jin‐Xin Miao, Xiang‐Xiang Wu, Yong‐Li Han, Xiao‐Lei Zhang, Wen‐Jing Chen, Qing‐Hua Wang, Yu Zhang, Yiping Fu, Yu‐ting Liu, Lin‐yan Lang, Wen‐Xia Zhao, Ming‐San Miao   +15 more
wiley   +1 more source

Observation of the light-triggered binding of pyrone to chymotrypsin by Laue x-ray crystallography. [PDF]

, 1991
Barry Stoddard, Paula M. Koenigs, Ned A. Porter, Kyriacos Petratos, Gregory A. Petsko, Dagmar Ringe   +5 more
openalex   +1 more source

Characterizing metal-binding sites in proteins with X-ray crystallography

Nature Protocols, 2018
K. Handing, E. Niedzialkowska, I. Shabalin, M. Kuhn, Heping Zheng, W. Minor   +5 more
semanticscholar   +1 more source

Durable Lithium Metal Anodes Enabled by {110}‐Textured Epitaxy on a LiF@Ag Commensurate Heterostructure

Advanced Science, EarlyView.
Utilizing their commensurate lattices, a LiF@Ag heterostructure is fabricated for Li epitaxy, featuring Ag nanoparticles grown on 2D LiF layers. The composition pinning effect inhibits Li‐Ag alloying and maintains the high lithiophilicity and fast adatom migration associated with Ag.
Liming Zhang, Xuemin Wang, Xiaotong Sun, Haobo Yang, Xinyi Miao, Zifeng Gu, Chuanzhong Chen, Cheng Hu   +7 more
wiley   +1 more source

Going around the Kok cycle of the water oxidation reaction with femtosecond X-ray crystallography. [PDF]

IUCrJ, 2023
Bhowmick A, Simon PS, Bogacz I, Hussein R, Zhang M, Makita H, Ibrahim M, Chatterjee R, Doyle MD, Cheah MH, Chernev P, Fuller FD, Fransson T, Alonso-Mori R, Brewster AS, Sauter NK, Bergmann U, Dobbek H, Zouni A, Messinger J, Kern J, Yachandra VK, Yano J.   +22 more
europepmc   +1 more source