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X-Ray Crystallography in Drug Discovery [PDF]
, 2009 Macromolecular X-ray crystallography is an important and powerful technique in drug discovery, used by pharmaceutical companies in the discovery process of new medicines. The detailed analysis of crystal structures of protein-ligand complexes allows the study of the specific interactions of a particular drug with its protein target at the atomic level.
Ana Luísa Carvalho +2 more
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Principles of Macromolecular X‐Ray Crystallography
Current Protocols in Protein Science, 1997AbstractX‐ray crystallography is one of the major tools available for protein structural analysis. This unit provides an introductory review of the principles of X‐ray crystallography that covers how the image is generated and analyzed. The second half of the unit describes strategies for producing crystals of protein, including methods for dealing ...
David R. Davies, Alison B. Hickman
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Ultrafast X-Ray Crystallography and Liquidography
Annual Review of Physical Chemistry, 2017Time-resolved X-ray diffraction provides direct information on three-dimensional structures of reacting molecules and thus can be used to elucidate structural dynamics of chemical and biological reactions. In this review, we discuss time-resolved X-ray diffraction on small molecules and proteins with particular emphasis on its application to ...
Key Young Oang +3 more
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Aspects of X-Ray Crystallography [PDF]
Nature, 1951 Selected Topics in X-Ray Crystallography from the Delft X-Ray Institutes Edited by J. Bouman. (Monographs on Theoretical and Applied Physics, Vol. 3.) Pp. xv + 375. (Amsterdam: North-Holland Publishing Co., 1951.) 76s.
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Automation in X-Ray Crystallography
Chemical & Engineering News Archive, 1963The contributions made to our understanding of chemistry through the use of crystallography have been numerous and, in some cases, spectacular.
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X-Ray Crystallography In Technology
Nature, 1953X-Ray Crystallographic Technology By Andre Guinier. English translation by T. L. Tippell; edited by Prof. Kathleen Lonsdale. Pp. xiii + 330 + 16 plates. (London: Hilger and Watts, Ltd., 1952.) 56s. net.
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An Introduction to X-Ray Crystallography
Measurement Science and Technology, 1997The first edition of Woolfson's An Introduction to X-ray Crystallography was published in 1970. It was a popular textbook for the senior undergraduate or graduate student beginning a serious study of x-ray crystallography. It was exactly what it claimed to be, a sound and uncompromising introduction for those intending to become professional ...
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Extinction in X-ray crystallography
Mineralogical Magazine and Journal of the Mineralogical Society, 1947Extinction is the increase in absorption that is to be expected when Bragg reflection of X-rays takes place in single crystals, and the corresponding decrease in intensity of reflection observed.The increase of absorption was directly observed in 1914 in two ways. Using the ionization spectrometer, W. H.
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X-ray Crystallography - Presentation
2016The present presentation discusses the principles of X-ray crystallography, focusing on the necessity of crystals for amplifying diffraction signals from molecules and the significance of Bragg's Law in determining structural information. It explains the scattering process, the importance of estimating crystallographic phases, and various methods for ...
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Screening Ligands by X-ray Crystallography
2014X-ray crystallography is an invaluable technique in structure-based drug discovery, including fragment-based drug discovery, because it is the only technique that can provide a complete three dimensional readout of the interaction between the small molecule and its macromolecular target.
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