Results 101 to 110 of about 75,914 (267)
Conversion of rat xanthine dehydrogenase to xanthine oxidase during oxidative stress
, 1988 The enzyme “xanthine oxidase” is one of the best characterized sources of superoxide anion and hydrogen peroxide. “in vivo” it mainly acts as a dehydrogenase which, by reducing NAD+, appears to be the physiologic form.
A. Bindoli +8 more
core +1 more source
Allergy, EarlyView.We compared Finnish and Russian Karelian adolescents with contrasting allergy burden using integrated proteomic, metabolomic, and transcriptomic profiling. Finnish adolescents showed a broader pro‐inflammatory PBMC secretory profile consistent with a low‐grade inflammatory phenotype.
Nanna Fyhrquist +11 more
wiley +1 more source
Quantification of Uric Acid or Xanthine in Plant Samples
Bio-Protocol, 2015 We developed this protocol to assay and quantify the content of uric acid or xanthine in various tissues of Arabidopsis thaliana mutant lines with defective urate oxidase or xanthine dehydrogenase1 and in their complementation and suppressor lines (Hauck
Oliver Hauck, Claus-Peter Witte
doaj +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To assess optic nerve head blood flow (ONHBF) autoregulation in patients with early‐ to moderate‐stage primary open‐angle glaucoma (POAG) and age‐ and sex‐matched healthy controls using laser speckle flowgraphy (LSFG) and isometric handgrip exercise.
Theresa Lindner +9 more
wiley +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
Xanthine based inhibitors for therapeutics targeting phosphodiesterase 9A
, 2016 Supervisors: Sanjukta Patra and Parameswar Krishnan IyerXanthine is a versatile nitrogenous alkaloid. The pharmaceutical active nature of xanthine derivatives is widely known for treating various diseases.
Singh, Nivedita
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Intestinal ischemic preconditioning: Less xanthine accumulation relates with less apoptosis
, 2015 Ischemic preconditioning has shown to reduce apoptosis in the intestinal mucosa during ischemia/reperfusion. This study evaluated if the decrease of apoptotic events found during preconditioning could be related with a reduction of the substrate (i.e ...
Solà, Anna M. +2 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley +1 more source
British Journal of Pharmacology, EarlyView.Created in BioRender. Schiavone, S. (2026). https://BioRender.com/cy0xq6z. Abstract Background and Purpose Autism spectrum disorders (ASD) are multifactorial neurodevelopmental conditions associated with oxidative stress and neuroinflammation across critical developmental periods.
Vladyslav Sikora +8 more
wiley +1 more source
The action of xanthin and methyl xanthins on the isolated intestine
Experimental Biology and Medicine, 1916 The tests were made with different concentrations of xanthin and its derivatives dissolved in Locke's solution which were carried out on segments of different parts of the intestine of the rabbit. Sodium xanthin in concentrations of 1 : 2,000 and 1 : 1,000 caused increased tonus which was more pronounced in the large than in the small intestine.
W. Salant, E. W. Schwartze
openaire +1 more source