Results 141 to 150 of about 65,785 (311)

Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Their bioactive constituents act through antioxidant, anti‐inflammatory, and metabolic‐regulating mechanisms, validating their classification as functional foods. Evidence from clinical and biochemical studies largely supports these benefits, although some claims stem from preliminary or in vitro findings.
Nighat Raza, Alina Sadaf, Reeha Mushtaq, Mirza Abid Mehmood, Luqman Amrao, Fakhar Islam, Muhammad Afzaal, Mohd Asif Shah   +7 more
wiley   +1 more source

Gnetumgams A and B: two new 2-phenylbenzofuran derivatives from the lianas of <i>Gnetum montanum</i> with xanthine oxidase inhibitory activity. [PDF]

RSC Adv
Van Do TN, Nguyen MH, Nguyen HX, Nguyen NT, Thi Nguyen MT.   +4 more
europepmc   +1 more source

Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity

, 2017
Andrija Šmelcerović, Katarina Tomović, Žaklina Šmelcerović, Živomir Petronijević, Gordana Kocić, Tihomir Tomašič, Žiga Jakopin, Marko Anderluh   +7 more
openalex   +1 more source

A Strategy for Inhibitors Screening of Xanthine Oxidase Based on Colorimetric Sensor Combined with Affinity Chromatography Technology

, 2023
Guoning Chen, Shuxian Zhang, Xiaofei Wang, Xiaoxuan Fan, Yuping Sa, Xueqin Ma   +5 more
openalex   +1 more source

Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men

Andrology, Volume 14, Issue 2, Page 466-479, February 2026.
Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.
Dingyuan Hu, Suping Niu, Fan Huang, Lu Jin, Qun Gu, Yanting Li, Chongyou Lee, Zhenwei Xie, Xiangxing Liu, Fang Men, Wenyan Zhao, Shuang Li, Yian Liu, Qian Wang, Huaying Fan, Jiaojiao Zhang, Shuangshuang Lin, Liming Chen, Yi Fang   +18 more
wiley   +1 more source

Enantioconvergent Access to Chiral S(VI) Stereocenters by Kinetic Resolution of Sulfonimidoyl Chlorides

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
An enantioconvergent approach for the kinetic resolution of S(VI) stereocenters that leverages the electrophilic reactivity of the chiral sulfur atom is described. The catalytic process provides access to sulfonimidoyl chlorides and sulfonimidates, which are among the least studied S(VI) functionalities.
Arko Das, Shree Krishna Dhakal, Ramon Trevino, Seth O. Fremin, Vy T. B. Nguyen, Arka Porey, Sachchida Nand, Chandan Kumar Giri, Daniel J. Wherritt, Hadi D. Arman, Oleg V. Larionov   +10 more
wiley   +2 more sources

Redox on the Clock: Sex-Dependent Dynamics of Xanthine Oxidoreductase Isoforms and Melatonin. [PDF]

Int J Mol Sci
Cecerska-Heryć E, Zoń M, Budkowska M, Serwin N, Michalczyk A, Goszka M, Polikowska A, Wojciuk B, Dołęgowska B.   +8 more
europepmc   +1 more source

Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases.
Mohitosh Biswas, Shobana John, Murshadul Alam Murad, Chonlaphat Sukasem   +3 more
wiley   +1 more source

Mechanism of xanthine oxidase in flap ischemia-reperfusion injury and advances in targeted therapy: a mini review. [PDF]

Front Physiol
Jia W, Wei X, Gong X.
europepmc   +1 more source

Genetic Determinants of Hematopoietic Toxicity Risk in Thai Pediatric Patients Undergoing 6‐Mercaptopurine Treatment

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT The nucleoside diphosphate‐linked moiety X‐type motif 15 (NUDT15) has been identified as a key genetic determinant of 6‐mercaptopurine (6‐MP)‐induced hematopoietic toxicity in populations with a high frequency of NUDT15 variants but a low frequency of thiopurine S‐methyltransferase (TPMT) variants.
Kanyarat Khaeso, Su‐on Chainansamit, Pitchayanan Kuwatjanakul, Patcharee Komvilaisak, Nontaya Nakkam, Kunanya Suwannaying, Suda Vannaprasaht, Areerat Dornsena, Wichittra Tassaneeyakul   +8 more
wiley   +1 more source