Results 141 to 150 of about 89,320 (324)
IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target
Cell Proliferation, EarlyView.IMPDH2 is a rate‐limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We
Zheng Li +8 more
wiley +1 more source
Developmental Medicine &Child Neurology, Volume 67, Issue 5, Page 591-599, May 2025.Hypoxic‐ischemic encephalopathy (HIE) is a neurologic condition that is caused by insufficient oxygen and blood flow to a newborn infant’s brain. Although therapeutic hypothermia can reduce the degree of brain injury in some infants with HIE, many infants with HIE will have significant lifelong disabilities despite receiving this treatment.
Natalie H. Chan +5 more
wiley +1 more source
Metabolomic and proteomic stratification of equine osteoarthritis
Equine Veterinary Journal, EarlyView.Abstract Background Equine osteoarthritis (OA) is predominantly diagnosed through clinical examination and radiography, leading to detection only after significant joint pathology. The pathogenesis of OA remains unclear and while many medications modify the disease's inflammatory components, no curative or reversal treatments exist.
James R. Anderson +5 more
wiley +1 more source
Xanthine scaffold: scope and potential in drug development
Heliyon, 2018 Medicinal plants have been the basis for discovery of various important marketed drugs. Xanthine is one such lead molecule. Xanthines in various forms (caffeine, theophylline, theobromine, etc) are abode in tea, coffee, cocoa, chocolate etc.
Nivedita Singh +3 more
doaj
The effect of light on xanthine oxidase activity [PDF]
, 1952 S. M. Siegel, Robert L. Weintraub
openalex +1 more source
The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets
The FEBS Journal, Volume 292, Issue 6, Page 1282-1315, March 2025.Disturbances of the microbiota–gut–brain axis are evident in people with Huntington's disease (HD) and in HD animal models. Here, we provide an overview of how the trillions of microorganisms residing in the gut, their secretory products, and the microbiota–gut–brain axis may contribute to HD pathogenesis.
Millicent N. Ekwudo +2 more
wiley +1 more source