Results 221 to 230 of about 147,306 (350)

Pharmacokinetics, pharmacodynamics and safety of casdatifan, a novel hypoxia‐inducible factor‐2α inhibitor, in healthy participants

British Journal of Clinical Pharmacology, Volume 91, Issue 12, Page 3366-3377, December 2025.
Aims Casdatifan is an orally bioavailable small‐molecule hypoxia‐inducible factor‐2α (HIF‐2α) inhibitor currently in development for treating patients with clear cell renal cell carcinomas. The aim of this study was to characterize the pharmacokinetics (PK), pharmacodynamics and safety of casdatifan in healthy participants.
Mohammad Ghasemi, Ji Yun Kim, Lisa Seitz, Lixia Jin, Paul G. Foster, Kai H. Liao, Tzuling Cheng, Elaine Paterson, Maria Velinova, Nicole Rivera Rosario, Reza Khosravan, Balaji Agoram   +11 more
wiley   +1 more source

Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders. [PDF]

Proc Natl Acad Sci U S A
Miotto MC, Luna-Figueroa E, Tchagou C, Bahlouli L, Reiken S, Dridi H, Liu Y, Weninger G, Marks AR.   +8 more
europepmc   +1 more source

Mesoionic xanthine analogs: antagonists of adenosine receptors

, 1984
Richard A. Glennon, Shanaz M. Tejani‐Butt, William L. Padgett, John W. Daly   +3 more
openalex   +1 more source

Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells. [PDF]

, 1992
Grégoire Dupont, Tom Huecksteadt, Bruce C. Marshall, Una Ryan, J R Michael, John R. Hoidal   +5 more
openalex   +1 more source

Opportunities and Challenges of the Application of Nuclear Magnetic Resonance‐Based Cerebrospinal Fluid Metabolomics for Clinical Research

Chemistry–Methods, Volume 5, Issue 12, November 2025.
Cerebrospinal fluid (CSF) is an important diagnostic matrix in neurology. This review illustrates the potentials and pitfalls of current CSF analysis by nuclear magnetic resonance. Created with BioRender.com in BioRender. Berezhnoy, G. (2025) https://BioRender.com/x80l903. Web of Science is owned by Clarivate.
Georgy Berezhnoy, Jannik Sprengel, Claire Cannet, Nils Pompe, Christoph Trautwein   +4 more
wiley   +1 more source

Guanine storage vacuoles sequester guanine crystals and serve as nitrogen reserves in <i>Chlamydomonas reinhardtii</i>. [PDF]

Proc Natl Acad Sci U S A
Goodenough U, Roth R, Lee JH.
europepmc   +1 more source

Effects of Combining Exercise and Dietary Shifts on Motor Coordination and Oxidative Markers in a High‐Fat Diet Model in Rats

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
Combining exercise with a healthier diet improved weight gain, motor coordination, and antioxidant profiles in liver and muscle tissues in a high‐fat diet rat model of Metabolic Associated Fatty Liver Disease (MAFLD). These interventions restored molecular markers, highlighting coordinated tissue benefits and their potential in managing MAFLD in both ...
Manuel Jiménez‐García, Maria Magdalena Quetglas‐Llabrés, Maria del Mar Ribas‐Taberner, Antoni Sureda‐Gomila, David Moranta‐Mesquida, Silvia Tejada‐Gavela   +5 more
wiley   +1 more source

<i>Limosilactobacillus</i><i>reuteri</i> Urob-7 Alleviates Hyperuricemia by Modulating Uric Acid Metabolism Through Nucleoside Degradation and Xanthine Oxidase Inhibition. [PDF]

Foods
Jing Y, Bai X, Qian H, Wang Y, Hao Y, Zhai Z, Zhang Z, Hao Y.   +7 more
europepmc   +1 more source

Phosphodiesterase Inhibitor 3-Isobutyl-1-Methyl-Xanthine Affects Ovarian Morphology and Stimulates Reproduction in Rabbits

, 2010
Alexander V. Sirotkin, Peter Chrenek, J. Pivko, Andrej Baláži, Alexander V. Makarevich   +4 more
openalex   +2 more sources

Isolation and Characterization of the Saccharomyces cerevisiae XPT1 Gene Encoding Xanthine Phosphoribosyl Transferase [PDF]

, 1999
Maria L. Guetsova, Timothy R. Crother, Michael W. Taylor, Bertrand Daignan‐Fornier   +3 more
openalex   +1 more source