Results 81 to 90 of about 107,799 (290)

7-Keto-Cholesterol and Cholestan-3beta, 5alpha, 6beta-Triol Induce Eryptosis through Distinct Pathways Leading to NADPH Oxidase and Nitric Oxide Synthase Activation [PDF]

, 2019
BACKGROUND/AIMS: We showed that patho-physiological concentrations of either 7-keto-cholesterol (7-KC), or cholestane-3beta, 5alpha, 6beta-triol (TRIOL) caused the eryptotic death of human red blood cells (RBC), strictly dependent on the early production
Allegra M., Attanzio A., Cilla A., Frazzitta A., Livrea M. A., Tesoriere L.   +5 more
core   +1 more source

Inosine triphosphate pyrophosphatase activity as a potential predictor of methotrexate remission in juvenile idiopathic arthritis

Arthritis &Rheumatology, Accepted Article.
Background Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients don't respond. Low inosine‐triphosphate‐pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated ITPA role and the underlying mechanisms in vitro.
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Xanthine oxidoreductase and xanthine oxidase in human cornea.

Histology and histopathology, 2002
Xanthine oxidoreductase (xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes the oxidation of hypoxanthine to xanthine, subsequently producing uric acid. The enzyme complex exists in separate but interconvertible forms, xanthine dehydrogenase and xanthine oxidase, which generate reactive oxygen species (ROS), a well known ...
Cejkova, J., Ardan, T., Filipec, M., Midelfart, A.   +3 more
openaire   +3 more sources

Reductive activation of potential antitumor bis(aziridinyl)benzoquinones by xanthine oxidase: Competition between oxygen reduction and quinone reduction [PDF]

, 1990
The reduction of a series of 2,5-bis(1-aziridinyl)-1,4-benzoquinone (BABQ) derivatives with various 3,6 substituents by the enzyme xanthine oxidase has been studied.
Janssen, L.H.M., Lusthof, K.J., Mol, N.J. de, Reinhoudt, D.N., Richter, W., Verboom, W.   +5 more
core   +3 more sources

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

A Review on Xanthine Oxidase-Based Electrochemical Biosensors: Food Safety and Quality Control Applications

Chemosensors
Electrochemical biosensors are integrated bio-receptor–transducer devices that convert specific biological interactions into measurable electrical signals.
Totka Dodevska
doaj   +1 more source

Sulfite: Cytochrome \u3cem\u3ec\u3c/em\u3e Oxidoreductase from \u3cem\u3eThiobacillus novellus\u3c/em\u3e [PDF]

, 2000
Direct oxidation of sulfite to sulfate occurs in various photo- and chemotrophic sulfur oxidizing microorganisms as the final step in the oxidation of reduced sulfur compounds and is catalyzed by sulfite:cytochrome c oxidoreductase (EC1.8.2.1).
Bennett, Brian, Dahl, Christiane, Deutzmann, Rainer, Kappler, Ulrike, McEwan, Alistair G., Rethmeier, Jörg, Schwarz, Günter   +6 more
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Application of Graphite Electrodes Prepared from Waste Zinc−Carbon Batteries for Electrochemical Detection of Xanthine

Chemosensors
Waste from zinc−carbon batteries poses a serious environmental protection problem. One of the main problems is also the reliable and rapid determination of some compounds that may be present in food and beverages consumed worldwide.
Milan B. Radovanović, Ana T. Simonović, Marija B. Petrović Mihajlović, Žaklina Z. Tasić, Milan M. Antonijević   +4 more
doaj   +1 more source

Xanthine Accumulation during Hypoxanthine Oxidation by Milk Xanthine Oxidase [PDF]

European Journal of Biochemistry, 1973
Accumulation of xanthine as well as uric acid, was found as a result of hypoxanthine oxidation by xanthine: oxygen oxidoreductase from milk. The ratio xanthine/uric acid increases with hypoxanthine concentration, and decreases with the enzyme concentration and the reaction time.
openaire   +2 more sources