Oxidative stress in the pathogenesis of type 1 diabetes: the role of adipocyte xanthine oxidase
Бюллетень сибирской медицины, 2018 Rationale. According to modern understanding, oxidative stress plays an essential role in the underlying mechanisms for the emergence of type 1 and type 2 diabetes and development of complications in these conditions.
V. V. Ivanov +7 more
doaj +1 more source
Quantification of Uric Acid or Xanthine in Plant Samples
Bio-Protocol, 2015 We developed this protocol to assay and quantify the content of uric acid or xanthine in various tissues of Arabidopsis thaliana mutant lines with defective urate oxidase or xanthine dehydrogenase1 and in their complementation and suppressor lines (Hauck
Oliver Hauck, Claus-Peter Witte
doaj +1 more source
Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function [PDF]
, 2014 Xanthine oxidase (XOD) is an enzyme which plays a central role in purine catabolism by converting hypoxanthine into xanthine and then further into uric acid.
Abooali, Maryam +5 more
core +1 more source
Biochemistry Changes That Occur after Death: Potential Markers for Determining Post-Mortem Interval [PDF]
, 2013 Death is likely to result in very extensive biochemical changes in all body tissues due to lack of circulating oxygen, altered enzymatic reactions, cellular degradation, and cessation of anabolic production of metabolites.
Donaldson, Andrea
core +1 more source
Distribuição da xantina oxidase no fígado e no sôro de rato
Memorias do Instituto Oswaldo Cruz, 1955 The localization of the xanthine oxidase (X.O.) and xanthine dehydrogenase (X.D.) activities in rat liver have been studied using separation of cytoplasmic particles into fractions by differential centrifugation.
Gilberto G. Villela +3 more
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Pharmacology and clinical drug candidates in redox medicine [PDF]
, 2015 SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I +11 more
core +3 more sources
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Binding Modes of Xanthine‐Derived Selective Allosteric Site Inhibitors of MTHFD2
ChemistryOpen, 2023 Methylenetetrahydrofolate dehydrogenase (MTHFD2) is a mitochondrial enzyme involved in 1 C metabolism that is upregulated in various cancer cells, but absent in normal proliferating cells. Xanthine derivatives are the first selective inhibitors of MTHFD2
Dr. Vibhu Jha +1 more
doaj +1 more source
XDH and XO Research and Drug Discovery—Personal History
Molecules, 2023 The author will outline the research history of the main issues addressed in this paper. The author has worked on this research himself. XDH, which is responsible for purine degradation, is present in various organisms.
Takeshi Nishino
doaj +1 more source
Literature-based discovery of diabetes- and ROS-related targets [PDF]
, 2010 Background Reactive oxygen species (ROS) are known mediators of cellular damage in multiple diseases including diabetic complications. Despite its importance, no comprehensive database is currently available for the genes associated with ROS.
A Erol +54 more
core +5 more sources