Binding Modes of Xanthine‐Derived Selective Allosteric Site Inhibitors of MTHFD2
ChemistryOpen, 2023 Methylenetetrahydrofolate dehydrogenase (MTHFD2) is a mitochondrial enzyme involved in 1 C metabolism that is upregulated in various cancer cells, but absent in normal proliferating cells. Xanthine derivatives are the first selective inhibitors of MTHFD2
Dr. Vibhu Jha +1 more
doaj +1 more source
XDH and XO Research and Drug Discovery—Personal History
Molecules, 2023 The author will outline the research history of the main issues addressed in this paper. The author has worked on this research himself. XDH, which is responsible for purine degradation, is present in various organisms.
Takeshi Nishino
doaj +1 more source
The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase. [PDF]
FEBS J, 2015 Nishino T +6 more
europepmc +3 more sources
Alcool e radicais livres de oxigénio.
Acta Médica Portuguesa, 1993 Oxygen free radicals may be generated during ethanol metabolization by cytochrome P450, or due to the formation of xanthine oxidase by ethanol effect on xanthine dehydrogenase.
M L Mira, C F Manso
doaj +1 more source
Determination of Flavin Potential in Proteins by Xanthine/Xanthine Oxidase Method
Bio-Protocol, 2020 This protocol describes a simple xanthine/xanthine oxidase enzymatic equilibration method for determination of the redox potential of a flavin. As an example of the use of this method, we determine the reduction potential of the covalently bound FAD ...
Elena Maklashina, Gary Cecchini
doaj +1 more source
A rice XANTHINE DEHYDROGENASE gene regulates leaf senescence and response to abiotic stresses
Crop Journal, 2022 Xanthine dehydrogenase, a member of the molybdenum enzyme family, participates in purine metabolism and catalyzes the generation of ureides from xanthine and hypoxanthine.
Jiangmin Xu +11 more
doaj
Effects of Cherry in Take Versus Allopurinol on Serum Uric Acid Levels, Biomarkers of Oxidative Stress and Hepatic Xanthine Oxidase/Xanthine Dehydrogenase Activity in Hyperuricemic Rats [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2008 Background and ObjectivesPrevention and treatment of hyperuricemia are based on control of uric acid levels. The aim of this study was to investigate the effect of oral administration of sour cherry and allopurinol on serum uric acid levels, biomarkers ...
F. Haidari +4 more
doaj +2 more sources
Nature Communications, 2019 The roles of the convertible forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO) during tumorigenesis is not known. Here, the authors develop XDH-stable and XO-locked knock-in (ki) mice and show increased tumor growth in XO ki mice, via ...
Teruo Kusano +11 more
doaj +1 more source
Phosphorylation of Xanthine Dehydrogenase/Oxidase in Hypoxia [PDF]
Journal of Biological Chemistry, 2001 The enzyme xanthine oxidase (XO) has been implicated in the pathogenesis of several disease processes, such as ischemia-reperfusion injury, because of its ability to generate reactive oxygen species. The expression of XO and its precursor xanthine dehydrogenase (XDH) is regulated at pre- and posttranslational levels by agents such as lipopolysaccharide
Raja Abdelnour +4 more
openaire +3 more sources
Regulation of aging by balancing mitochondrial function and antioxidant levels
Journal of Physiological Sciences, 2022 Aging is the deterioration of physiological mechanisms that is associated with getting old. There is a link between aging and mitochondrial function. However, there is an unresolved relationship between ATP levels and aging.
Sawako Yoshina +3 more
doaj +1 more source